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chemokine/chemokine receptor pair CC L20/CC R6 in humancolorectal malignancy:An overview

World Journal of Gastroenterology 2016年第2期22卷 833-841页

作者： Vilma Oliveira Frick Claudia Rubie Ulrich Keilholz Pirus Ghadjar Department of General- Visceral-Vascular-and Pediatric SurgeryUniversity of the Saarland66421 Homburg/SaarGermany CharitéComprehensive Cancer Center CharitéUniversitätsmedizin BerlinCampus CharitéMitte10117 BerlinGermany Department of Radiation Oncology CharitéUniversitätsmedizin Berlin13353 BerlinGermany

chemokines belong to a superfamily of small, cytokinelike proteins, which induce multiple physiological functions, particularly cytoskeletal rearrangement and compartment-specific migration through their interaction with G-protein-coupled receptors. chemokines and their receptors have been widely acknowledged as essential and selective mediators in leukocyte migration in inflammatory response. It is now established that the chemokine/chemokine receptor system is also used by cancer cells to direct lymphatic and haematogenous spreading and additionally has an impact on the site of metastatic growth of different tumours. In recent years an increasing number of studies have drawn attention to CC-chemokine cysteine motif chemokine ligand 20(CCL20) and its physiological sole receptor CCR6 to play a role in the onset, development and metastatic spread of various gastrointestinal cancer entities. Among various cancer types CCR6 was also demonstrated to be significantly overexpressed in colorectal cancer(CRC) and stimulation by its physiological ligand CCL20 has been reported to promote CRC cell proliferation and migration in vitro. Further, the CCL20/CCR6 system apparently plays a role in the organ-selective liver metastasis of CRC. Here we review the literature on expression patterns of CCL20 and CCR6 and their physiological interactions as well as the currently presumed role of CCL20 and CCR6 in the formation of CRC and the development of liver metastasis, providing a potential basis for novel treatment strategies.

关键词： chemokine/chemokine receptor pair CCR6 chemokine ligand 20 Colorectal cancer Metastasis Liver

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