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Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology

Chinese Chemical Letters 2012年第6期23卷 727-730页

作者： Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu College of Biological Science and Biotechnology Beijing Forestry University Beijing 100083 China Hainan Branch of Institute of Medicinal Plant Development （Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine） Chinese Academy of Medical Sciences Wanning 571533 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100193 China School of Food ＆ Bioengineering Shandong Polytechnic University Jinan 250353 China

We used whole-tree agarwood-induction technology to produce agarwood from Aquilaria sinensis trees within 20 months, and evaluated the quality of this agarwood. The results showed its characteristics were similar to those of high-grade wild agarwood in terms of texture, chemical constituents, essential oil content, and ethanol-soluble extract content, with the lattermost quality far surpassing the requirement of traditional Chinese medicine agarwood, as indicated in Chinese Pharmacopoeia 2010. To the best of our knowledge, this is first study to show that high-quality agarwood can be produced in whole A. sinensis trees via a chemically induced technology.

关键词： Agarwood Aquilaria sinensis chemically induced Quality Whole-tree agarwood-induction technology

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SITE SPECIFIC CANCER INDUCTION BY INTRA-ESOPHA-GEAL COTTON NODE RETENTION AND CARCINOGEN LADEN DRINKING WATER

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Chinese Journal of Cancer Research 1998年第2期10卷 36-39页

作者：路建平林肇辉 Department of Pathology Shanghai Medical University Shanghai 200032 China Department of Pathology Okayama University Medical School 700 Japan

Objective: To reveal the relationship between the restriction of esophagus and the esophageal carcinogenesis. Methods: Male Wistar rats weighing 200±20g (N=50) observed as experimental animals. Using carcinogen NethylNbutylnitrosamine (EBN), or NnitrosomethylNpropylamine (MPN), esophageal carcinogenesis was induced. In some rats, a cotton node was detained in the thoracic segment of the esophageal lumen to make artificial restriction. The rats were divided into 6 groups. Group EC or MC were those treated with the artificial restriction and EBN, or MPN. Group E, M or C included those treated only with EBN, MPN, or cotton node. Group U was untreated control. The rats were sacrificed, and the esophagus from the 6 groups of rats were compared. Results: On naked eye examination, the esophageal lesion was the most in EC group, followed by MC group. About 70% of the lesions were within 3mm from the thread node. The E or M group only had a few lesions. There was no observable lesion in the C and U groups. Histological examination found that the hyperplasia, hyperkeratosis, papilloma, and dysplasia were significantly more in EC and MC groups than E and M groups. Severe dysplasia and carcinoma in situ were only noticed in the EC and MC groups. Conclusion: It is suggested that the artificial restriction promotes the esophageal carcinogenesis. The effect is related with increased contact with carcinogen and injury at the area of the restriction.

关键词： Artificial restriction Esophageal carcinoma chemically induced Rat

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