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MMP14 is a diagnostic gene of intrahepatic cholangiocarcinoma associated with immune cell infiltration

World Journal of Gastroenterology 2023年第19期29卷 2961-2978页

作者： Jun Wu Yang Guo Zhi-Fan Zuo Zi-Wei Zhu Lei Han China Medical University The General Hospital of Northern Theater Command Training Base for GraduateShenyang 110016Liaoning ProvinceChina Department of Hepatobiliary Surgery The General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina Gynecological Radiotherapy Ward Liaoning Provincial Cancer HospitalShenyang 110801Liaoning provinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant tumor of the hepatobiliary system with concealed onset,strong invasiveness and poor *** To explore the disease characteristic genes that may be helpful in the diagnosis of ICC and affect immune cell *** We downloaded two ICC-related human gene expression profiles from GEO database as the training group(GSE26566 and GSE32958 datasets)for difference analysis,and performed enrichment analysis on differential *** least absolute shrinkage and selection operator(LASSO),support vector machinerecursive feature elimination(SVM-RFE)and random forest(RF),three machine learning algorithms,were used to screen the characteristic *** verification was carried out on GSE107943 and The Cancer Genome Atlas,two verification *** operating characteristic curve and area under the curve(AUC)were used to evaluate the diagnostic efficacy of genes for *** and ssGSEA algorithms were used to evaluate the effect of characteristic genes on immune infiltration *** Protein Atlas(HPA)was used to analyze the protein expression level of the target *** A total of 1091 differential genes were obtained in the training *** analysis showed that the above genes were mainly enriched in small molecular catabolism,complement and coagulation cascade,bile secretion and other functions and *** characteristic genes were screened by LASSO regression,19 by SVM-RFE algorithm,and 30 by RF *** algorithms were used in combination to determine the characteristic gene of ICC:*** verification group confirmed that the genes had a high diagnostic accuracy(AUC values of the training group and the verification group were 0.960,0.999,and 0.977,respectively).Comprehensive analysis of immune infiltration showed that MMP14 could affect the infiltration of monocytes,activated memory CD4 T cells,resting memory CD4 T cells,and other immune cells

关键词： Intrahepatic cholangiocarcinoma MMP14 Machine learning Immune infiltration characteristic gene Diagnostic markers

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