检索结果-南通市图书馆

The association of Triatoma maculata(Ericsson 1848) with the gecko Thecadactylus rapicauda(Houttuyn 1782)(Reptilia:Squamata:Gekkonidae):a strategy of domiciliation of the chagas disease peridomestic vector in Venezuela?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 279-284页

作者： Reyes-Lugo M Reyes-Contreras M Salvi I Gelves W Avilan A Llavaneras D Navarrete LF Cordero G Sanchez EE Rodriguez-Acosta A Medical Entomology Section Institute of Tropical MedicineUniversidad Central de VenezuelaCaracasVenezuela School of Biology Universidad Simon BolivarCaracasVenezuela Immunochemistry Section Tropical Medicine InstituteUniversidad Central de VenezuelaCaracasVenezuela Tropical Zoology Institute Universidad Central de VenezuelaCaracasVenezuela Texas A&M University-Kingsville Department of ChemistryKingsvilleTexasUSA Instituto Nacional de Higiene Rafael Rangel CaracasVenezuela

Objective:To investigate the bioecological relationship between chagas disease peridomestic vectors and reptiles as source of ***:In a three-story building,triatomines were captured by direct search and electric vacuum cleaner search in and outside the ***,age structure of the captured Triatoma maculata(***) were identified and *** living in sympatric with the triatomines were also ***:*** were found living sympatric with geckos(Thecadactylus rapicauda) and they bit residents of the apartment building in study.A total of 1 448 individuals of *** were captured within three days,of which 74.2%(1 074 eggs) were eggs,21.5%were nymphs at different stages,and 4.3%were ***:The association of *** and *** is an effective strategy of colonizing dwellings located in the vicinity of the habitat where both species are present;and therefore,could have implications of high importance in the intradomiciliary transmission of chagas disease.

关键词： chagas disease Gekkonidae Reduviidae Thecadactylus rapicauda Triatoma maculate Trypanosoma cruzi Vector domiciliation

A Decreased Expression and Functionality of Muscarinic Cholinergic Receptor in Acute chagas Myocarditis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2014年第6期4卷 305-315页

作者： M. Labrador-Hernández L. Jiménez G. Leon R. López W. Mendoza C. Bonfante-Rodriguez J. Torres-Peraza R. Bonfante-Cabarcas Biochemistry Research Unit School of Medicine Universidad Centroccidental “Lisandro Alvarado” Barquisimeto Venezuela Medical Parasitology Research Unit School of Medicine Universidad Centroccidental “Lisandro Alvarado” Barquisimeto Venezuela

Background: chagas disease is still a public health problem because of the remaining high prevalence, the expansion of the disease into developed countries and the re-emergences by oral transmission outbreaks. chagas cardiomyopathy evolves as a consequence of an autonomic un-balance where the parasympathetic tone is undermined. Objective: To determine the functionality and expression of muscarinic cholinergic receptors in acute chagas disease. Methodology: 62 male, 3-week-old Sprague Dawley rats were assayed;32 were infected with Trypanosoma cruzi trypo-mastigotes and 30 were healthy controls. Electrocardiographic studies were conducted in the absence or presence of direct muscarinic (oxotremorine and McN-A-343) or indirect agonists (phenylephrine) or antagonist (pirenzepine). Muscarinic M1 and M2 receptor expression was determined by radioligand [3H]-QNB binding assay and immunoblot. Results: chagasic acute myocarditis was sustained by electrocardiographic signs and histopathological findings. Bradycardia induced by oxotremorine was significantly higher in healthy rats (HR) and the differences were enhanced by CsCl. In the absence of the agonist, CsCl induced a greater bradycardia in chagasic rats (ChR). In HR McN-A-343 induced tachycardia, however it induces bradycardia in the presence of a acetylcholinesterase inhibitor (neostigmine);no effects were observed in ChR. Pirenzepine induced a higher tachycardia in HR. Phenylephrine in the presence of pirenzepine induced a similar bradycardia in both groups, but recovery was faster in ChR. Muscarinic M1 and M2 receptor density was higher in HR. Conclusion: Muscarinic receptor expression and functionality are decreased in the acute chagas disease that could impact the evolution and prognosis of the disease.

关键词： Acute chagas Disease Muscarinic Receptors Oxotremorine CsCl McN-A-343 Phenyleprhine Pirenzepine [3H]-QNB Sprague Dawley Rats

chagas Disease: Proposal of Health Education for Community Health Workers in the City of Petrolina, Pernambuco, Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2015年第13期7卷 1806-1811页

作者： Alexsandro Paulo Costa Galdino Junior Cícera Aurea Fontes Vilela ícaro Sampaio Inácio Jamille Conduru Mendes Segatto Mykaelly Pereira Clemente Ricardo Santana de Lima Medical School Federal University of Vale do Sao Francisco Petrolina Brazil Nurse Family Health Strategy of the City Petrolina Petrolina Brazil Biological Sciences Federal University of Vale do Sao Francisco Petrolina Brazil

The Education for Health at PET Work Program (PET-Health) is focused on education as a pre-supposition. Actions are directed towards to the integration of service-learning and community. Interdisciplinary principle is directed from fusion of work of graduate students, academics and professionals of health services for the benefit of strengthening primary care and health surveillance. This work aimed to carry out educational activities with Community Health Agents (ACS) of the health facilities of PET-health, with the theme of chagas disease. This descriptive cross-sectional study was carried out from January to May 2013, and the sample consisted of 25 active ACS in six Basic Health Units in the city of Petrolina, Brazil. In spite of actuation of ACS in primary care for over 10 years, a limited knowledge has been developed about this pathology. The health education workshops developed by the PET group clarified the ACS on chagas disease allowing them to have an expansion of knowledge about the vector, habitat Barber, transmission, clinical manifestations… After the workshop, it was found that the ACS expanded their knowledge about the disease cycle, expanding the possibilities for action in the prevention of this pathology in their respective coverage areas. This work shows an important form of integration between education, service and community that can govern the new direction of health education.

关键词： chagas Disease American Trypanosomiasis Health Education Primary Health Care Public Health

Exploring the molecular mechanism and core genes of chronic chagas cardiomyopathy based on gene expression microarray

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

South China Journal of Cardiology 2019年第2期20卷 108-116页

作者： LU Jian-jun FENG Zhe HE Yong-li WANG Rui HUANG Cheng ZHOU Ying-ling The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510282Guangdong Department of Cardiology Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong Department of Medical Services First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080Guangdong Department of Cardiology First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471003HenanChina

Background Chronic chagas cardiomyopathy(CCM)is an infectious disease which could lead to severe dilated cardiomyopathy. Intensive efforts have been made to elucidate the pathogeny,but the molecular mechanisms of CCM are still not well understood. The present study was designed to identify differentially expressed genes(DEGs),and to exploring the molecular mechanism and core genes that may be involved in the disease progression of CCM. Methods A microarray dataset GSE84796 was downloaded from Gene Expression Omnibus(GEO)database. The DEGs were identified. Then Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis and protein-protein interaction(PPI)network analyses were performed by DAVID,STRING and Cytoscape. Results A total of 786 DEGs were identified,consisting of703 downregulated genes and 83 upregulated genes. The enriched biological process(BP)analysis revealed that DEGs included genes for adaptive immune response,regulation of immune and inflammatory response. Five of the most important six BP in advanced CCM were associated with immune injury and the other one was associated with inflammatory response. From the most important module of PPI network,24 DEGs with degrees≥ 35 were identified as core genes,among which 22 genes are associated to immune damage,and the other 2 genes are related to inflammatory reaction. Conclusion This study has proved the importance of immune injury in the progression of advanced CCM. Meanwhile,the core genes may provide molecular targets for the diagnosis or drug intervention of CCM in the future study.[S Chin J Cardiol 2019;20(2):108-116]

关键词： chronic chagas cardiomyopathy(CCM) dilated cardiomyopathy immune response core gene enrichment analysis

维普期刊数据库

Modulation of immune response in experimental chagas disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Experimental Medicine 2013年第1期3卷 1-10页

作者： Beatriz Basso Neonatology Service School of Medical SciencesNational University of Cordoba

Trypanosoma cruzi(T. cruzi), the etiological agent of chagas disease, affects nearly 18 million people in Latin America and 90 million are at risk of infection. The parasite presents two stages of medical importance in the host, the amastigote, intracellular replicating form, and the extracellular trypomastigote, the infective form. Thus infection by T. cruzi induces a complex immune response that involves effectors and regulatory mechanisms. That is why control of the infection requires a strong humoral and cellular immune response; hence, the outcome of host-parasite interaction in the early stages of infection is extremely important. A critical event during this period of the infection is innate immune response, in which the macrophage's role is vital. Thus, after being phagocytized, the parasite is able to develop intracellularly; however, during later periods, these cells induce its elimination by means of toxic metabolites. In turn, as the infection progresses, adaptive immune response mechanisms are triggered through the TH1 and TH2 responses. Finally, T. cruzi, like other protozoa such as Leishmania and Toxoplasma, have numerous evasive mechanisms to the immune response that make it possible to spread around the host. In our Laboratory we have developed a vaccination model in mice with Trypanosoma rangeli, nonpathogenic to humans, which modulates the immune response to infection by T. cruzi, thus protecting them. Vaccinated animals showed an important innate response(modulation of NO and other metabolites, cytokines, activation of macrophages), a strong adaptive cellular response and significant increase in specific antibodies. The modulation caused early elimination of the parasites, low parasitaemia, the absence of histological lesions and high survival rates. Even though progress has been made in the knowledge of some of these mechanisms, new studies must be conducted which could target further prophylactic and therapeutic trials against T. cruzi infectio

关键词： Trypanosoma cruzi chagas disease Innate and adaptive immune response

Cardiomyopathy protection in chagas Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2013年第7期3卷 442-447页

作者： Jorge E. Mitelman Luisa Gimenez Instituto Centenario Buenos Aires Argentine Chagas Disease of the Inter-American Society of Cardiology Buenos Aires Argentine Department of Chagas the University Institute of Health Science Foundation H A Barcelo Buenos Aires Argentine Teodoro Alvarez Hospital Buenos Aires Argentine Cardiology in Northern Province of Buenos Aires Buenos Aires Argentine Chagas in the City of Buenos Aires Buenos Aires Argentine University Institute of Health Science Foundation H A Barcelo Buenos Aires Argentine

There is some published evidence suggesting micro vascular endothelial dysfunction and dysautonomia involvement in chagas disease in association with cardiomyocyte changes favoring disease progression. The combined treatment between angiotensin converting enzyme (ACE) inhibitor drugs;Simvastatin, muscarinic antibody immunoadsorbent together with fungicidal drugs would open therapeutic possibilities in this disease.

关键词： chagas Disease Chronic Period without Demonstrable Pathology Ex Indeterminate Phase Endothelial Dysfunction Cardiac Dysautonomia Simvastatin ACE (Angiotensin Converting Enzyme) Inhibitor Muscarinic Antibody

chagas病早期出现的抗毒蕈碱受体自身抗体和异常迷走神经调节

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(心脏病学分册) 2007年第9期 52-53页

作者： Ribeiro A.L.P. Giménez L.E.D. Hernández C.C.Q. 郭俊 Postgraduate Course of Tropical Medicine School of Medicine Av. Alfredo Balena 190 30130-100 Belo Horizonte Brazil

背景:已知自身免疫和自主神经功能异常是chagas病(ChD)的特点,这与其发病机制相关。本研究旨在评估伴或不伴左室(LV)功能障碍的ChD患者的心率变异性(HRV)和抗毒蕈碱(M2)受体自身抗体水平,以确定

关键词：迷走神经受体 RV 第十对脑神经副交感神经系统自身抗体 chagas

使用苄硝唑治疗或不予治疗对慢性chagas病长期心脏预后影响的对比:一项随机试验

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 5-6页

作者： Viotti R. Vigliano C. Lococo B. 罗亮 José Hernández 3440 Buenos Aires ZC 1653Argentina Dr.

背景:苄硝唑用于chagas病急性期治疗是有效的,但是其对未确定阶段和慢性期的治疗效果尚不清楚。目的:对比接受苄硝唑治疗的非急性chagas病患者与未治疗患者的长期预后。设计:非盲法。

关键词：患者血清学 chagas 心力衰竭

维普期刊数据库

研发并验证可预测chagas心脏病死亡的风险评分

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 6-7页

作者： Rassi Jr. A. Rassi A. Little W.C. 马超 Division of Cardiology Anis Rassi Hospital Ave. Jose Alves 453 Setor Oeste Goinia GO 74.110-020 BrazilDr

背景:chagas病是拉丁美洲的一个重要健康问题,心脏受累与高水平的发病率及死亡率相关。作者研发了一种预测chagas心脏病患者死亡风险的模型。方法:回顾性评价一个巴西地区队列中的424例门诊患者。采用Cox比例风险分析研究潜在危险因素... 详细信息

背景:chagas病是拉丁美洲的一个重要健康问题,心脏受累与高水平的发病率及死亡率相关。作者研发了一种预测chagas心脏病患者死亡风险的模型。方法:回顾性评价一个巴西地区队列中的424例门诊患者。采用Cox比例风险分析研究潜在危险因素与死亡的关系,并建立风险评分模型。在另一社区医院的153例患者中对该模型进行验证。结果:在平均7.9年的随访期内,模型研发队列中有130例患者死亡。

关键词：心脏病死亡 chagas 心脏受累评分模型潜在危险因素回顾性评价死亡风险风险分析动态心电

维普期刊数据库