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Phenolic compounds from chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways

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Food Science and Human Wellness 2023年第4期12卷 1071-1080页

作者： Fuxia Hu Chao Liu Fengqin Wang Changxin Zhou Maotong Zhu Dongxiao Sun-Waterhouse Zhaosheng Wang Key Laboratory of Food Processing Technology and Quality Control in Shandong Province College of Food Science and EngineeringShandong Agricultural UniversityTaian 271018China Key Laboratory of Novel Food Resources Processing Ministry of Agriculture and Rural AffairsKey Laboratory of Agro-Products Processing Technology of Shandong ProvinceInstitute of Agro-Food Science and TechnologyJinan 250100China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand

chaenomeles speciosa(Sweet)Nakai cultivated widely in temperate regions possesses anti-inflammatory properties,however,the underlying molecular mechanisms remain not fully *** this study,a purified phenolic extract of *** rich in chlorogenic acid,procyanidin B1 and catechin(determined by HPLC-Q-TOF-MS/MS)exhibited dose-dependent anti-inflammatory effects on lipopolysaccharide(LPS)-treated RAW264.7 *** extract at 30μg/mL was most potent and enabled most cells in normal morphology under LPS stimulation without causing *** extract suppressed the levels of nitric oxide(NO),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-1β(IL-1β),and the mRNA and protein expressions of nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2).The mechanisms underlying such anti-inflammatory actions included the regulation of phosphorylation of related proteins to monitor the expressions of inflammatory mediators and genes in the nuclear factor kappa-B(NF-κB)and mitogen-activated protein kinase(MAPK)signaling ***,the phenolic extract from *** is a desirable anti-inflammatory agent for inflammatory conditions to meet the rising demand for natural and cost-effective therapeutics.

关键词： chaenomeles speciosa Phenolic extract Purification Anti-inflammatory

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The CsMYB123 and CsbHLH111 are involved in drought stress‑induced anthocyanin biosynthesis in chaenomeles speciosa

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Molecular Horticulture 2023年第1期3卷 51-63页

作者： Yanshen Ren Shuangyu Zhang Qianyi Zhao Yang Wu Houhua Li College of Landscape Architecture and Art Northwest A&F UniversityYangling 712100ShaanxiChina

Drought stress has been demonstrated to enhance the biosynthesis of anthocyanins in the leaves,resulting in an increased aesthetic ***,the molecular mechanisms underlying drought-induced anthocyanin biosynthesis in chaenomeles speciosa remain *** this study,the metabolites of *** leaves were analyzed,and it was found that the content of cyanidin-3-O-rutinoside increased significantly under drought *** differentially expressed genes CsMYB123 and CsbHLH111 were isolated by transcriptomics data analysis and gene cloning,and gene overexpression and VIGS experiments verified that both play important roles in anthocyanin ***,Y1H and Dual-luciferase reporter assay showed that CsMYB123 binds to the promoters of anthocyanin biosynthesis-related structural genes(such as CsCHI,CsF3H,and CsANS),while CsbHLH111 was shown to bind to the promoter of CsCHI,positively regulating its ***,BIFC and Y2H assays unveiled potential protein–protein interactions between CsMYB123 and CsbHLH111 at the cell ***,these results shed light on the critical roles played by CsMYB123 and CsbHLH111 in anthocyanin biosynthesis,thus providing a valuable insight into understanding the molecular mechanisms of how the MYB and bHLH genes regulate anthocyanin biosynthesis in the process of leaf coloration in ***.

关键词： chaenomeles speciosa Drought CsbHLH111 CsMYB123 Anthocyanin

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Anti-inflammatory and immunomodulatory effects of the glucosides of cheanomeles speciosa and its relative mechanism

Anti-inflammatory and immunomodulatory effects of the glucos...

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第十五届国际药理学大会

作者： Zhang Lingling Dai Min Zheng Yongqiu Wei Wei . Institute of Clinical Pharmacology Anhui Medical University. Hefei 230032 China

＜正＞ To observe the anti - inflammatory and immunomodulatory effects of glucosides of chaenomeles speciosa（GCS） and relative mechanism in collagen - induced arthritis （CIA） rat. The effects of GCS were measured by histopathological assessment of *** -*** and PGE2 production in synoviocytes cAMP level and mRNA expression of Gi,Gs. and TNF in *** were significant secon dary inflammatory reactionsin CIA rats, companying the elevation of IL - 1, TNF and PGE2. GCS could significantly inhibit inflammatory swelling. IL- 1. TNF and PGE2 production, and reduced elevated spleens index, proliferation of T cell and B *** increased cAMP level and mRNA expression of Gs. and inhibited mRNA expression of Gi. TNF. and reduced histopathological changes *** has anti - inflammatory effects and immunomodulatory activities. The effects of GCS on rats CIA may be related to modulating G protein - AC - cAMP signal transduction of synoviocytes.

关键词： chaenomeles speciosa glucoside immunomodulatory collageninduced arthritis

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