检索结果-南通市图书馆

The Prevalence of High Grade cervical Intraepithelial Neoplasia (CIN) in a Primary Human Papillomavirus (HPV) cervical screening Programme Population with HPV Positive and Cytology Negative Smear Results

引用

Open Journal of Obstetrics and Gynecology 2020年第7期10卷 902-908页

作者： Simon G. Williams Ayesha Anwar Sachinta G. Wijesiri Sangeetha Palaparthy Emma Winter Specialty Trainee in O&G South Tyneside and Sunderland NHS Foundation Trust Sunderland UK Consultant Obstetrician and Gynaecologist North Cumbria Integrated Care NHS Foundation Trust Carlisle UK Specialty Trainee in O&G County Durham and Darlington NHS Foundation Trust Durham UK Specialty Trainee in O&G Queen Elizabeth University Hospital Glasgow UK Specialty Doctor in Gynaecology and Colposcopy Services North Cumbria Integrated Care NHS Trust Carlisle UK

High-risk HPV is found in 99.7% of cervical cancers. The causative role of HPV in cervical cancer has led to the inclusion of HPV testing as part of cervical screening. A pilot of HPV testing as primary screening was commenced in 2013 at six pilot sites in England. North Cumbria Integrated Care (NCIC) NHS Foundation Trust took part in the pilot, in which women with an HPV-positive/cytology-negative result were recalled at 12 months. Women with HPV type 16/18 found at initial screening and persisting at 12 months in spite of negative cytology were referred to Colposcopy services at 12 months. Women with smear positive for hrHPV other than 16/18 types were recalled twice at 12 and 24 months before referral to colposcopy. Persistent hrHPV positive/cytology negative smear at 12 and 24 months initiated a colposcopy referral. Objective: To assess the prevalence of high grade CIN and invasive cancer in patients referred to colposcopy services at NCIC NHS Foundation Trust with hrHPV positive/cytology negative smears. Method: The study was conducted at NCIC NHS Foundation Trust between January 2015 and December 2017. Data was collected retrospectively from the colposcopy data base (INFOFLEX). All patients with HPV positive/cytology negative smears seen in colposcopy clinic during the study period were included. Patients with high grade CIN, cervical glandular intraepithelial neoplasia (CGIN) or invasive cancer were recorded. Results: 763 women were included in the study. A total of 50 (6.6%) women had high grade CIN, CGIN or invasive cancer. 40 of these 50 women (80%) were treated by large loop excision of the transformation zone (LLETZ). <

关键词： cervical screening cervical Intraepithelial Neoplasia cervical Cancer Human Papillomavirus Colposcopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between the Type of Reproductive Tract HPV Infection and cervical Lesion in Qinghai Area: A Retrospective Study

引用

世界最新医学信息文摘 2019年第93期19卷 7-11页

作者： Ifrah·Abdullah GUO Gui-lan Graduate school of Qinghai University Affiliated hospital of Qinghai university

Objective(1) To explore the correlation between HPV genotype versus biopsy pathological diagnosis by using Fisher exact test.(2) To explore the correlation between extent of TCT cytological abnormality versus biopsy pathological diagnosis by using gamma correlation test.(3) To explore the demographic distribution of TCT-HPV positive diagnosis among Qinghai women by their age specific prevalence. Methods This study retrospectively utilized hospital records at Qinghai Hospital, patients attending the department of obstetrics and gynecology, between April 2014 to December 2018. The exposure of interest was HPV positive diagnosis measured by TCT. For all patients that fit criteria for age(18-70 years) and non-comorbid to other gynecological cancers were sorted for data collection. Their cervical screening results, HPV-genotyping and biopsy's pathological diagnoses were recorded. HPV distribution among eligible participants was descriptively illustrated by age-specific prevalence. The correlation between extent of TCT cytological abnormality versus biopsy pathological diagnosis by using gamma correlation test. A computer software SPSS 24.0 was used. Also, the correlation between HPV genotype versus biopsy pathological diagnosis by using Fisher exact test. Results A total of 1120 patients fulfilled criteria for participation in the study(mean age of 45.43+/-5 years). HPV-16 was the most prevalent genotype, accounting for 26.70% of all the people tested, followed by HPV-58 and HPV-52, accounting for 17.50% and 17.32, Age group 21-30 accounted for highest prevalence of HPV positive *** correlation between extent of TCT cytological abnormality versus biopsy pathological diagnosis showed, gamma correlation test of 0.561(P<0.001). The correlation between HPV genotype versus biopsy pathological diagnosis, showed Fisher exact test of P-value<0.005. Conclusion Accounting for highest prevalence, 41-50-year age-group is mostly associated with HPV-16 genotype and mostly ca

关键词： cervical screening Human papilloma virus Thinprep cytology test

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：