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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第5期32卷 746-749页

作者：李嫚彭君宋艳玲梁慧梅元武方瑗 Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Neurology Central Hospital of Weinan

This study examined the effect of electro-acupuncture (EA) combined with transcranial magnetic stimulation (TMS) therapy at different time windows on learning and memory ability of rats with cerebral infarction and the underlying mechanism.Two hundred SD rats were randomly divided into four groups:normal group,sham-operated group,model group and EA+TMS group,and each group was then divided into five sub-groups in terms of the different time to start treatment post operation:6,12,24,48 and 72 h.cerebral infarction models were established in the model and the EA+TMS groups by left middle cerebral artery occlusion/reperfusion (MCAO/R).After treatment for 14 d,the Morris water maze test was applied to examine the spatial learning and memory abilities of rats.In infarcted area,the expression of caspase-3 was immunohistochemically detected,and real-time fluorescent quantitative PCR was used to measure the expression of Bcl-2 mRNA.The results showed that in EA+TMS group compared with model group at the same treatment time windows,the escape latency was substantially shortened,the expression of caspase-3 was considerably decreased and the expression level of Bcl-2 mRNA significantly increased (Pcerebral infarction by increasing the expression level of Bcl-2 mRNA and decreasing the expression of caspase-3.The best time window is 24 h after perfusion treatment to ischemia.

关键词： cerebral infarction electro-acupuncture transcranial magnetic stimulation escape latency apoptosis

Oral myiasis after cerebral infarction in an elderly male patient from southern China:A case report

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World Journal of Clinical Cases 2020年第24期8卷 6499-6503页

作者： Tie-Zhu Zhang Ying Jiang Xin-Tong Luo Rui Ling Jing-Wen Wang Department of Stomatology The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina

BACKGROUND Myiasis is a rare but risky pathology caused by a parasitic infestation of humansand animals by the dipterous larva. Oral myiasis occurs when soft tissues of theoral cavity are invaded by the larvae of flies. It is not a common disease for thereason that the oral cavity is not easily reachable for the fly to lay eggs. But it cancause pain, infection, uncomfortable feeling when the worms move, tissuedestruction and/or even life-threatening hemorrhages.CASE SUMMARY We reported a case of oral myiasis after cerebral infarction in a 78-year-old malepatient from southern China (Guangdong Zhanjiang). As a result of cerebralinfarction, he suffered from right hemiplegia, mobility and mental decline forabout 3 mo. He had difficulty swallowing and was fed via a feeding tube. Hemostly engaged in mouth breathing and had poor oral and dental hygiene. Morethan 20 live larvae were collected from the patient’s oral cavity, which werelocalized in the maxillary gingiva, the mandibular gingiva and the tongue. Thepatient recovered after the routine oral cleaning, removal of maggots,debridement and anti-infection treatment.CONCLUSION Early diagnosis and treatment of this infestation are essential due to thebothersome symptoms, such as inflammation, intense anxiety over the larvaemovement, possible serious complications, etc. Clinical staff should be familiarwith this infestation, and this disease should be considered, especially inphysically and mentally disabled patients or those at significant risk for infection.Necessary measures, including good sanitation, personal and environmentalhygiene and special care should be adopted so as to prevent this disease.

关键词： Oral myiasis Larva Oral cavity cerebral infarction Case report

Protective Effects of Overexpression of bcl-xl Gene on Local cerebral infarction in Transgenic Mice Undergoing Permanent Occlusion of Middle cerebral Artery

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第1期28卷 56-59页

作者：王芙蓉姜永生张苏明肖文伍朱遂强 Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

In order to investigate the protective effects of the overexpression of bcl-xl gene on local cerebral infarction in the transgenic mice subject to permanent occlusion of middle cerebral artery, the models of bcl-xl transgenic mice were established and subjected to cerebral infarction by intraluminal occlusion of the middle cerebral artery. The infarct volume and the neurological scores were observed and comparison between the wild type mice and the transgenic mice was made. It was found that the infarct volume and the neurological scores in the transgenic mice were significantly decreased as compared with those in the wild type mice. It was suggested that the overexpression of bcl-xl gene in transgenic mice could reduce the infarct volume and improve the neurological function of the mice.

关键词： bcl-xl gene transgenic mice cerebral infarction

Study on the Correlation of Tongue Manifestation with Fibrinogen and Neutrophil in Acute cerebral infarction Patients

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Chinese Journal of Integrative Medicine 2012年第12期18卷 942-945页

作者：高利刘萍宋珏娴刘倩许长敏黄礼媛王平平赵海苹罗玉敏 Department of Neurology Xuanwu Hospital of Capital Medical University Cerebrovascular Diseases Research Institute Xuanwu Hospital of Capital Medical University Key Laboratory of Neurodegenerative Diseases(Capital Medical University) Ministry of Education

Objective： To investigate the correlation of tongue manifestation with the fibrinogen level and the neutrophil count in blood of acute cerebral infarction patients. Methods： A total of 200 patients with first unilateral cerebral infarction in Neurology Department of Xuanwu Hospital from March, 2008 to February, 2009 were recruited in this study. The correlation of the tongue fur color and texture with the blood fibrinogen level and the neutrophil count was analyzed in these patients. Results： The level of fibrinogen and neutrophil count in thick fur group were significantly higher than that in thin fur group （P〈0.05）. There was no statistical difference in the level of fibrinogen and neutrophil count found between moist fur and dry fur. Statistical significance existed in the level of fibrinogen between the greasy tongue fur group and non-greasy tongue fur group （P〈0.05）. The level of fibrinogen and the neutrophil count were compared among different fur color groups, revealing that the level of fibrinogen in yellowish fur group was higher than that of white fur group and normal value with statistical significance （P〈0.05） with neutrophil count in yellowish fur group being significantly higher than that in white fur group. Conclusion： Our results suggested that the change of tongue manifestation was associated with the level of fibrinogen and the neutrophil count in the blood of cerebral infarction patients.

关键词： cerebral infarction tongue manifestation fibrinogen neutrophil

A Meta-analysis of β-fibrinogen Gene-455G/A Polymorphism and Plasma Fibrinogen Level in Chinese cerebral infarction Patients

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Biomedical and Environmental Sciences 2007年第5期20卷 366-372页

作者： XIAO-CHAO CHEN MING-TONG XU WU ZHOU CHUN-LI HAN WEI-QING CHEN Department of Cardiology The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000 Guangdong China Department of Endocrinology The Second Affiliated Hospital Sun Yat-sen University Guangzhou 510120 Guangdong China Department of Epidemiology The Public Health College Sun Yat-sen University Guangzhou 510080 Guangdong China

Objective To evaluate the correlation between the β-fibrinogen gene-455G/A polymorphism and cerebral infarction in Chinese population by means of meta-analysis. Methods Genetic association studies on evaluating the β-fibrinogen gene -455G/A polymorphism and cerebral infarction involving Chinese population published before December 2005 were collected from database of PubMed, EMBASE, and CNKI. All the data in literature were abstracted based on the defined selection criteria by two independent investigators. Publication bias was tested by funnel plot and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Review Manager （Version 4.2） was used for meta-analysis. Results Eleven studies including 1405 patients and 1600 controls met the selection criteria. There was no publication bias in 11 reviewed studies. Heterogeneity test of reviewed studies showed statistically significant differences （χ^2=24.58, P=0.006） among the ORs of individual studies. The combined OR of 11 studies of susceptibility to cerebral infarction in –455A allele carriers compared with the -455G/G wild homozygotes was 1.33 （95%CI 1.04-1.71, P=0.02）. In the patients with cerebral infarction in 6 studies, the summarized average plasma fibrinogen level of allele A carrier was 0.29 g/L （95%CI 0.14-0.44, P=0.0002） higher than that of -455G/G homozygous ones. Conclusions β-fibrinogen gene -455G/A polymorphism might contribute to susceptibility of cerebral infarction in Chinese population; allele A increases the individual susceptibility to the disease.

关键词： β-fibrinogen Gene polymorphism cerebral infarction Meta-analysis

Changes in serum cellular adhesion molecule and matrix metalloproteinase-9 levels in patients with cerebral infarction following hyperbaric oxygen therapy A case and intergroup control study

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Neural Regeneration Research 2008年第11期3卷 1245-1248页

作者： Renliang Zhao Chunxia Wang Yongjun Wang Department of Neurology the Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China Department of Neurology Beijing Tiantan Hospital Capital University of Medical Sciences Beijing 100050 China Qingdao Mental Health Center Qingdao 266034 Shandong Province China

BACKGROUND： Animal studies have confirmed that hyperbaric oxygen （HBO） therapy can reduce matrix metalloproteinase activity and blood brain barrier permeability, thereby exhibiting neuroprotective effects. However, at present, consensus does not exist in terms of its clinical efficacy. OBJECTIVE： To validate the significance of changes in serum cellular adhesion molecule and MMP-9 levels in patients with cerebral infarction following HBO therapy. DESIGN, TIME AND SETTING： This randomized, controlled, neurobiochemical study was performed at the Department of Neurology, Affiliated Hospital of Qingdao University Medical College between December 2002 and March 2006. PARTICIPANTS： A total of 112 patients with acute cerebral infarction of internal carotid artery, comprising 64 males and 48 females, averaging （67 ±11） years, were recruited and randomized to a HBO group （n = 50） and a routine treatment group （n = 62）. An additional 30 gender- and age-matched normal subjects, consisting of 17 males and 13 females, averaging （63 ± 9） years, were enrolled as control subjects. METHODS： The routine treatment group received routine drug treatment and rehabilitation exercise. HBO treatment was additionally performed in the HBO group, once a day, for a total of 10 days. MAIN OUTCOME MEASURES： Serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were detected by enzyme linked immunosorbent assay. RESULTS： Upon admission, serum levels of soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, soluble E-selectin, and matrix metalloproteinase-9 were significantly increased in patients with cerebral infarction, compared with control subjects （P 〈 0.01）. Following HBO and routine treatments, serum levels of the above-mentioned indices were significantly reduced in the HBO and routine treatment groups （P 〈 0.01）. Moreover, greater efficacy was observed in the HBO group, compared with the routine treatment group （P 〈

关键词： cerebral infarction E-selectin hyperbaric oxygen intercellular adhesion molecule matrix metalloproteinase-9 vascular cell adhesion molecule

Effect of Panaxtriol Saponins on synaptophysin and postsynaptic density-95 expression at different periods of cerebral infarction

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Neural Regeneration Research 2008年第11期3卷 1212-1217页

作者： Fangyuan Cui Jiangying Zhai Weimeng Zou Xiling Wang Yihuai Zou Linggqun Zhu Department of Neurology Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine Beijing 100700 China Key Laboratory of Chinese Internal Medicine Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine Beijing 100700 China

BACKGROUND： The change in expression of synaptophysin （Syp） and postsynaptic density-95 （PSD-95） alters after cerebral infarction, and the plasticity of synapses contributes greatly to nerve function recovery. Chinese medicinal substances may play an important role in the expression of Syp and PSD-95. OBJECTIVE： To observe the effect of Panaxtriol Saponins （PTS）, an active component in Sanqi tongshu capsules, on the expression of Syp and PSD-95 after cerebral infarction at different time points in rats, so as to examine the cerebral function remodeling mechanism. DESIGN, TIME AND SETTING： A randomized and controlled observation which was performed in Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine from January to March, 2007. MATERIALS： Twenty-six healthy male Sprague Dawley rats were used to establish middle cerebral artery occlusion based on the Longa method. Sanqi tongshu capsules （containing 100 mg PTS per tablet） were provided by the Chengdu Huashen Group and nimodipine tablets （30 mg） by Tianjin Zhongyang Pharmaceutical Co., Ltd. METHODS： Twenty-six rats were randomly divided into an operation group （n = 21 ） and a control group （n = 5）. The operation group underwent the EZ Longa procedure to make the middle cerebral artery occlusion model. After surgery rats were randomly divided into a model group, a PTS group and a nimodipine group, with seven rats in each group. Rats were intragastrically administrated with saline （2 mL/d） in the model group, with Sanqi tongshu capsule （5.4 mg/100 g/d） in the PTS group, and with nimodipine （1.73 mg/100 g/d） in the nimodipine group. Rats in the control group did not undergo model establishment and drug administration. MAIN OUTCOME MEASURES： The expressions of Syp and PSD-95 were measured by immunohistochemical and image analysis at days 3, 7 and 28 after the operation. RESULTS： The expression of Syp and PSD-95 in the operation group was significantly lower than in the control group at days 3, 7, 28 postoperatively （P 〈 0.05）. The expression of Syp

关键词： Panaxtriol Saponins cerebral infarction remodeling synaptophysin postsynaptic density-95

Assessment of the Diagnostic Value of Plasma Level of Von Willebrand Factor and ADAMTS13 in Patients with cerebral infarction

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Open Journal of Blood Diseases 2022年第4期12卷 110-123页

作者： Basant Magdy Abdulla Aziza Abbas Ahmed Dalia Mahmoud Eldawy Lamiaa Ismail Ahmed Clinical Pathology Department Faculty of Medicine for Girls Al-Azhar University Cairo Egypt Internal Medicine Department Faculty of Medicine for Girls Al Azhar University Cairo Egypt

Background: Von Willebrand Factor (VWF) is a large multimeric plasma gly-coprotein that plays an important role in primary haemostasis. VWF together with ADAMTS13 plays a key role in arterial thrombosis. VWF is integral for platelet adhesion to collagen fibres and atherosclerotic plaues and platelets aggregation under high shear conditions. Upon vascular wall damage, plasma VWF binds to collagen in the exposed endothelial matrix and platelet glycoprotein triggers platelet aggregation and thrombous formation. In the early stages of acute ischaemic stroke, VWF increased significantly and the ADAMTS13 level decreased. The increase of plasma VWF and FVIII in a patient with ischaemic stroke indicated an increased risk of complications and severe neurological deficit. Objective: to evaluate the validity of VWF and ADFAMTS13 as diagnostic markers of cerebral infarction by comparing the two markers’ validity in diagnosis. Methods: this case control study enrolled 38 cerebral infarction patients 20 acute infarction and 18 recurrent infarction. Patients were compared with 65 age and sex with control patients. We performed the VWF assay using the minividas immunofluorescence technique and the ADAMTS13 assay using the ELISA technique. Results: VWF level of acute infarction patients (280.97 ± 109.83 IU/dl) while its level in recurrent infarction (264.93 ± 172.8 IU/dl) were highly significantly increased compared to control (75.8 ± 16.24 IU/dl). ADAMTS13 level of acute infarction patients was (506.11 ± 225.24 ng/dl) and (1386.03 ± 667.64 ng/dl) in recurrent infarction patients with highly significant differences between the acute and control group and non-significant different between recurrent and control. ADAMTS13 is an excellent diagnostic test in acute cerebral infarction but a weak diagnostic test in recurrent cerebral infarction but it is a good diagnostic test in differentiation between acute and recurrent cerebral infarction patients. VWF is an excellent diagnostic test in both acute and recurrent cases. In acute infar

关键词： VWF ADAMTS13 cerebral infarction

Validity and reliability of Chinese version of Fatigue Impact Scale in cerebral infarction patients

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Neural Regeneration Research 2008年第2期3卷 177-181页

作者： Chunwei Wu Zhandong Liu Yongbo Zhang Jimei Li Dexin Wang Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

BACKGROUND： Post-stroke fatigue has received much attention recently. Three evaluation scales are available, including the Fatigue Impact Scale （FIS）. Yet none of these has been proven to be of use in the evaluation of psychological quality after post-stroke fatigue. OBJECTIVE： To introduce FIS into China, and to evaluate the validity and reliability of the Chinese Version in patients with cerebral infarction. DESIGN： Scale evaluation. SETTING： Department of Rehabilitation, Beijing Friendship Hospital, Capital Medical University. PARTICIPANTS： A total of 330 patients with cerebral infarction were selected from the Department of Neurology, Beijing Friendship Hospital, Capital Medical University from June 2005 to December 2006. All patients met diagnostic standards from the Fourth National Cerebrovascular Disease Academic Meeting of China Medical Association and were diagnosed with CT or MRI examination. Patients who were not willing to accept scale evaluation were excluded. METHODS： The English version of FIS was translated into Chinese and subsequently translated back to English again. FIS was given to the discharged patients, and they returned them upon completion. In-patients completed and immediately returned the FIS. Validity and reliability of the retrieved scales were ascertained with descriptive and inference analysis. MAIN OUTCOME MEASURES： Total scores and subscale scores of FIS. RESULTS： Out of 330 questionnaires, 214 valid questionnaires were deemed valid in total. Six components were extracted in factor analysis, and the total cumulative contribution was 73.919%, which suggested the questionnaire was valid. After correlation analysis, 6 components were divided into 3 subscales, including cognitive, physical, and social, which was the same as the English version. The Cronbach α value for the three subscales was 0.937 7, 0.918 8, and 0.940 6, respectively （〉 0.7）. CONCLUSION： The reliability and validity of the Chinese version of FIS met with satisfaction and appeared to be adaptable to ce

关键词： cerebral infarction fatigue validity reliability scales

Responses of serum inflammatory factor high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in elderly males with cerebral infarction Non-randomized concurrent control

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Neural Regeneration Research 2008年第5期3卷 498-500页

作者： Guiping Jiao Xinjie Tan Zhiliu Yuan Chunling Li Jing Wang Wen Mo Department of Medicine for Cadre the People＇s Hospital of Guizhou Province Guiyang 550002 Guizhou Province China

BACKGROUND： cerebral infarction is poorly treated due to neuronal necrosis and secondary pathophysiological changes; for example, free radical production and inflammatory reactions. OBJECTIVE： To detect the levels of high-sensitivity C-reactive protein （hs-CRP）, interleukin-6 （IL-6）, and tumor necrosis factor- a （TNF- α ） in elderly males with cerebral infarction. DESIGN： Non-randomized current control study. SETTING： Cadre Medical Department, Guizhou Provincial People＇s Hospital. PARTICIPANTS： Forty elderly males （65-89 years old） with cerebral infarction were selected from Cadre Medical Department, Guizhou Provincial People＇s Hospital from February 2004 to December 2006. All patients met the diagnostic criteria of cerebral infarction modified at the 4th National Cerebrovascular Disease Academic Meeting, and were diagnosed on the basis of CT or MRI tests. Furthermore, 35 elderly male inpatients （65-87 years old） without cerebral infarction were selected as the control group. Included subjects provided confirmed consent and did not have heart disease, diabetes mellitus, lipid disorder, acute trauma, infection, rheumatism, or other inflammatory diseases. The study was approved by the local ethics committee. There were no significant differences in age, blood pressure, and lipid levels between the cerebral infarction group and the control group （P 〉 0.05）, and this suggested that the baseline data of both groups were comparable. METHODS： Fasting venous blood was drawn from cerebral infarction patients 24 hours after cerebral infarction attack and from control subjects 24 hours after hospitalization. A latex-enhanced immunoturbidimetric assay and an enzyme-linked immunosorbent assay were used to detect the levels of hs-CRP, IL-6, and TNF- α in the serum. MAIN OUTCOME MEASURES： The levels of hs-CRP, 1L-6, and TNF- α in the serum in both groups. RESULTS： Forty cerebral infarction patients and thirty-five control subjects were included in the final analysis without any loss. Levels of hs-CRP, IL-6, and TNF-α in the cer

关键词： high-sensitivity C-reactive protein interleukin tumor necrosis factor-alpha： elderly males cerebral infarction