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Is cerebral cavernous malformation a pre-glioma lesion？

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Chinese Medical Journal 2012年第24期125卷 4511-4513页

作者： ZHANG Ji-yang MING Zong-yi WU An-hua Department of Neurosurgery First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Neurosurgery 463 Hospital Shenyang Liaoning 110042 China

Glioma is the most malignant tumor in the brain, the origin of glioma is still unknown. Recently some papers indicated that glioma may be developed from cerebral cavernous malformation （CCM）. We describe a man with a right temporal lobe CCM, after gamma-knife radiotherapy, the patient developed a low-grade astrocytoma in the area of the preexistent CCM. This case, together with other reports, may indicated an oncogenetic properties of CCM, and we proposed that CCM may be a pre-glioma lesion.

关键词： glioma cerebral cavernous malformation radiotherapy

Pregnancy Combined with Epilepsy and cerebral cavernous malformation

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Chinese Medical Journal 2017年第5期130卷 619-620页

作者： Ya-Lan Xu Jun-Tao Liu Yi-Jun Song Xi-Ya Zhou Qing-Wei Qi Xu-Ming Bian Zhi-Qin Xu Lei Li Department of Obstetrics and Gynecology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Neurosurgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

INTRODUCTIOIN cerebral cavernous malformation （CCM）, also known as cavernous angioma, is a type of vascular malformation in the central nervous system. To date, rare cases of CCM and seizure have been reported in pr... 详细信息

关键词： cerebral cavernous malformation Delivery Hemorrhage Pregnancy

Outcomes after surgical and nonsurgical treatment of pediatric cerebral cavernous malformation

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Pediatric Investigation 2024年第2期8卷 126-134页

作者： Haohao Zhang Qishuai Yu Zhiqi Mao Liang Zhang Xinguang Yu Medical School of Nankai University TianjinChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurosurgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Importance:Pediatric cerebral cavernous malformation(CCM)is a rarely encountered vascular *** study on surgical excision and nonsurgical management outcomes of CCM in pediatrics is ***:To determine the demographic characteristics,hemorrhage rate,and long-term outcomes of pediatric patients with ***:A retrospective study of pediatric patients with CCM in Chinese PLA General Hospital was conducted between January 2004 and January *** compared the clinical characteristics,radiological features,and outcomes of the surgical and nonsurgical ***:Seventy-nine children were included,with 69.6%being boys,and the average age was 11.8±5.5 *** annual retrospective hemorrhagic rate was 5.7%per patient per ***-six children(70.9%)underwent surgical excision,and they were more likely to present with seizure symptoms(P=0.011),have a higher proportion of larger lesion size(P=0.008),less likely to have durations≤10 days(P=0.048),and less likely to have supratentorial deep CCM(P=0.014)compared to children who received nonsurgical *** resection was achieved in most surgical cases(55,98.2%).During the 143.9±50.8 months of follow-up,44 patients(78.6%)achieved improvement,12 patients(17.8%)remained the same,and two(3.6%)experienced *** the nonsurgical management group,14 children(60.9%)experienced symptom improvement,eight(34.8%)remained the same,and one(4.3%)worsened,with a re-hemorrhagic risk of 8.7%.Interpretation:Surgical removal of pediatric CCM can eliminate the risk of hemorrhage and lead to satisfactory *** children undergoing nonsurgical management,long-term close monitoring is essential due to the life-long risk of hemorrhage.

关键词： Pediatric cerebral cavernous malformation Surgery Hemorrhage

Microsurgical Treatment of Suptratentorial cerebral cavernous malformation Associated with Epilepsy

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Microsurgical Treatment of Suptratentorial Cerebral Cavernou...

cerebral glioblastoma mimicking a cavernous malformation: A case report and literature review

2011年浙江省神经外科学学术年会

作者： Department of Neurosurgery,The First Affiliated Hospital,Wenzhou Medical College, Wenzhou,China 325000 YE Sheng,ZHUGE Qi-Chuan,LIN Chen,ZHANG Yu,WU Zhe-Bao,PANG Jin-Qian, WU Jin-Sen,ZHENG Wei-Ming.

Objective The present study was designed to evaluate the surgical procedure,taken according to intra-operative vEEG monitoring,of patients harboring one or more supratentorial cerebral cavernous malformations,with epileptic *** and Methods 25 cases,admitted to our department between January 1998 and June 2005,harboring one or more supratentorial cerebral cavernous malformations(CCMs), with epileptic seizures,were studied *** were divided into two groups according to vEEG examination and *** A included patients with epileptic focus and CCM located in or near area motoria,and group B included patients with epileptic focus and CCM away from area ***-operative vEEG monitoring had been used,and the disappearance of sharp wave,spike wave and spike-ware wave were taken as the key-sign for the end of microsurgical *** Lab neuronavigation has been applied in 12 patients with deep-located *** All the CCMs had been totally resected,without peri-operative death and permanent neurological *** them,5 patients received CCM resection only,and 7 patients had CCM and surrounding hemosiderin-stained brain tissue resected,and the other 13 patients had done partly cortex lesionectomy,resection of hippocampus and amygdaloid nuclear,cortex thermocoagulation,and multiple subpial transaction,besides CCM resection with or without resection of surrounding hemosiderin-stained brain tissue. After 10 to 54 months following-up,6 patients had EngelⅠand 2 patients had EngelⅡand 1 patient had EngelⅢoutcome in group A,and all 16 patients had EngelⅠoutcome in group B(IA 13,IB 3).Conclusion Different surgical procedures were used in different patients,and the intra-operative vEEG monitoring took an important role in procedure *** most cases,excision of the CCM and focal epilepto-genicity under intra-operative vEEG monitoring is safe and effective for seizure *** incomplete lesion excision,as it l

关键词： cerebral cavernous malformation focal epilepto-genicity surgical procedure intraoperative video EEG monitoring

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Translational Neuroscience and Clinics 2017年第1期3卷 35-39页

作者： Jiefei Li Yuqi Zhang Huancong Zuo Department of Neurosurgery Tsinghua University Yuquan Hospital

Glioblastomas are highly malignant and invasive brain tumors. cerebral cavernous malformations(CCMs) are vascular diseases of congenital and occult vascular dysplasia, which may arise sporadically or may be inherited due to autosomal dominant condition. To the best of our knowledge, cases of glioblastoma in the cerebral hemisphere mimicking cavernous malformation have not been reported in the literature. We reported a case of glioblastoma mimicking CCM. The patient was admitted at our hospital in July 2015 due to a 9-day history of intermittent dizziness. The present study reports a case of a glioblastoma on the right temporal lobe mimicking CCM, which was confirmed by postoperative pathology. The diagnosis of glioblastoma was not determined even during surgery, and the lesion was totally resected with no complications. During the surgical procedure, the lesion was very similar to a CCM. In conclusion, it is difficult to distinguish between glioblastoma and CCM. Therefore, when a lesion is present with hemorrhage and the imaging features are very similar to a vascular disease, a tumor must be considered in the differential diagnosis.

关键词： glioblastoma cerebral cavernous malformation intracranial hemorrhage neurosurgery

Novel technologies and models for studying pharmacological activities of traditional Chinese medicine for promoting blood circulation and removing blood stasis

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中国药理学与毒理学杂志 2021年第10期35卷 740-741页

作者： ZHAO Yang WEI Zhong-hong YU Su-yun WANG Ai-yun CHEN Wen-xing ZHENG Xiang-jian Mathew VADAS Jennifer GAMBLE LU Yin Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative Medicine Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Pharmacy Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjing 210023China Department of Pharmacology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Centre for the Endothelium Vascular Biology ProgramCentenary InstituteThe University of SydneySydney 2050Australia

OBJECTIVE Our previous studies demonstrated that various ingredients from the traditional Chinese medicine(TCM)for promoting blood circulation and removing blood stasis,as exemplified by cryptotanshinone and salvianolic acid B,exerted striking effects on modulating angiogenesis and vascular permeability,which suggests that they may be effective in treating vascular leak-driven diseases(***,cerebral cavernous malformation and diabetic retinopathy).However,the lack of reliable and advanced technologies and models sets up difficult hurdles for better understanding the role of TCM for promoting blood circulation and removing blood *** this end,this study is to outline numerous cutting-edge platforms that can be utilized for exploring the function of TCM for promoting blood circulation and removing blood stasis in vascular leak-driven *** Two-photon laser scanning fluorescence microscopy was used to observe the interactions between neutrophils and blood vessels in a real-time *** flow system was employed to mimic the in vivo behaviors of ***1-Tag5 spontaneous pancreatic cancer model was used to study the function of tumor blood ***2ECKO(deletion of CCM2 in endothelial cells)mice were employed to establish the cerebral cavernous malformation(CCM)animal ***-computed tomography(micro-CT)was utilized to assess the CCM lesion.Müller cell-knockout mouse model was used to study the progression of diabetic *** permeability in this model was assessed by fluorescein *** The interactions between neutrophils and endothelial cells involve a series of complicated processes,including rolling,adhesion,intraluminal crawling and transmigration,which were all monitored in vivo by two-photon laser scanning fluorescence microscopy in a real-time *** flow system was capable of recapitulating the biological behaviors of neutrophils in *** vascular function in particular vascular

关键词： traditional Chinese medicine blood circulation blood stasis tumor vessels cerebral cavernous malformation diabetic retinopathy

Resection of Intracranial Giant cavernous malformation: Case Report and Literature Review

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Surgical Science 2024年第2期15卷 28-35页

作者： Vinicios Rivelli Da Fonseca Cleverson Martins Kill Mariana Alcantara Hugo Fialho Leonnan De Sa Oliveira Lucidio Souza Filho Department of Neurosurgery Hospital Santa Rita Belo Horizonte Brazil

cerebral cavernous malformations are a rare and congenital vascular malformation that can present as a challenge in neurosurgical management. The term “giant cerebral cavernous malformations” still does not have a clear definition in the literature, with a wide variety of results. It is known, however, that there is an association between the size of the cavernoma and postoperative sequelae, especially in those with a size greater than 3 cm in its largest diameter. We present a case report of resection of a giant brain cavernoma measuring approximately 8 cm in its largest diameter, emphasizing on clinical presentation, diagnoses and postoperative evolution. Additionally, we performed a comprehensive review of the existing literature on the subject, addressing the epidemiology, pathophysiology, diagnostic methods, treatment options, and prognosis associated with this condition.

关键词： cavernous malformation cerebral cavernous malformation Giant cavernous malformation cavernous Hemangioma cavernous Angioma Cavernoma Giant Cavernoma