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Journal of Mechanics Engineering and Automation 2021年第4期11卷 97-104页

作者： Natalia Lineth Baquero-Salas Luis Mario Mateus-Sandoval Structural Integrity Group Department of Mechanical EngineeringUniversidad de Los AndesColombia

The present paper sought to redesign,technify and adjust to different sizes of a mini-standing to improve the physical therapy of children from 4 to 9 years old with mild cerebral palsy or in medical conditions that moderately affect their lower *** orthopedic attachment provides support to the calf of the patient,resembling its body to a cantilevered *** allows the patient to improve their posture and safety and prevent bone *** achieve this attachment,simplified design techniques were complemented with Autodesk Inventor finite elements,also additive manufacturing in Polylactic Acid polymer PLA was used for structural parts like the calf support;Likewise,Computerized Numerical Control(CNC)was carried out on Nylon 6/6,a material used due to hygiene and lubrication between parts.A functional and safe prototype is obtained that meets the required age range,whose limitations are children of 120 cm or 30 *** were determined in the design requirements and verified with own replicable tests,as well with ASTM(American Society of Testing Materials)standards.

关键词： Orthopedic attachment cerebral palsy additive manufacturing physiotherapy adjustability.

Thyroxine Level of Children with cerebral palsy

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中国临床神经科学 2000年第Z1期8卷 97-页

作者： Zhang Jie Department of Neurology The Children Hospital of Hunan Province Changsha 410007

Objective:To investigate the thyroxine level of Children with cerebral palsy so as to understand thd changes of their nevous endocrine. Methods:Radioimmunoassay was applied to 57 Children with cerebral palsy and 108 normal *** serum level of tridothyronine(T3), thyroxine(T4)free tridothyronine(FT3),free thyroxin(FT4),and thyroid stimulating hormone(TSH) were measured for those children in the moming and and in condition without any food Rsults: (1)Chiidren with cerebral palsy all showed low T3 *** difference of T3 value between CP children and norrmal children was significant (P＜0.001). (2)Results from groups with difference ages:the CP toddler′s age group also showed low T4 and FT4 values The difference of T4 and FT4 values between the toddler′s age CP childrengroup and the toddler′s age normal children group tegted was significant (CP＜0.01 for T4, P ＜0. 05 for FT4): Conclusion:The tlyroxine level of children with cerebral palsy showed lower values compared to normal children, especisly, the low T3 values were significant.

关键词： cerebral palsy thyroid stimulating hormone

Nicotinamide adenine dinucleotide treatment confers resistance to neonatal ischemia and hypoxia:effects on neurobehavioral phenotypes

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Neural Regeneration Research 2024年第12期19卷 2760-2772页

作者： Xiaowen Xu Xinxin Wang Li Zhang Yiming Jin Lili Li Meifang Jin Lianyong Li Hong Ni Division of Brain Science Institute of Pediatric ResearchChildren’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatric Orthopedics Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral ***,there are few effective clinical treatments for neonatal hypoxic-ischemic brain ***,we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide,which can protect against hypoxic injury in adulthood,in a mouse model of neonatal hypoxic-ischemic brain *** this study,nicotinamide adenine dinucleotide(5 mg/kg)was intraperitoneally administered 30 minutes befo re surgery and every 24 hours *** results showed that nicotinamide adenine dinucleotide treatment improved body weight,brain structure,adenosine triphosphate levels,oxidative damage,neurobehavioral test outcomes,and seizure threshold in experimental *** mass tag proteomics revealed that numerous proteins were altered after nicotinamide adenine dinucleotide treatment in hypoxic-ischemic brain injury *** reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine(or cysteine)peptidase inhibitor,clade A,member 3N,fibronectin 1,5'-nucleotidase,cytosolic IA,microtubule associated protein 2,and complexin *** analyses showed that nicotinamide adenine dinucleotide ameliorated hypoxic-ischemic injury through inflammation-related signaling pathways(e.g.,nuclear factor-kappa B,mitogen-activated protein kinase,and phosphatidylinositol 3 kinase/protein kinase B).These findings suggest that nicotinamide adenine dinucleotide treatment can improve neurobehavioral phenotypes in hypoxic-ischemic brain injury mice through inflammation-related pathways.

关键词： brain injury cerebral palsy hypoxia hypoxic-ischemic brain injury inflammation neuroprotection nicotinamide adenine dinucleotide neonate nicotinamide adenine dinucleotide proteomics

Corticoreticular tract lesion in children with developmental delay presenting with gait dysfunction and trunk instability

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Neural Regeneration Research 2017年第9期12卷 1465-1471页

作者： Yong Min Kwon Jessica Rose Ae Ryoung Kim Su Min Son Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Orthopedic Surgery College of Medicine Stanford University

The corticoreticular tract （CRT） is known to be involved in walking and postural control. Using diffusion tensor tractography （DTT）, we investigated the relationship between the CRT and gait dysfunction, includ- ing trunk instability, in pediatric patients. Thirty patients with delayed development and 15 age-matched, typically-developed （TD） children were recruited. Fifteen patients with gait dysfunction （bilateral trunk instability） were included in the group A, and the other 15 patients with gait dysfunction （unilateral trunk instability） were included in the group B. The Growth Motor Function Classification System, Functional Ambulation Category scale, and Functional Ambulation Category scale were used for measurement of functional state. Fractional anisotropy, apparent diffusion coefficient, fiber number, and tract integrity of the CRT and corticospinal tract were measured. Diffusion parameters or integrity of corticospinal tract were not significantly different in the three study groups. However, CRT results revealed that both CRTs were disrupted in the group A, whereas CRT disruption in the hemispheres contralateral to clinical mani- festations was observed in the group B. Fractional anisotropy values and fiber numbers in both CRTs were decreased in the group A than in the group TD. The extents of decreases of fractional anisotropy values and fiber numbers on the ipsilateral side relative to those on the contralateral side were greater in the group B than in the group TD. Functional evaluation data and clinical manifestations were found to show strong correlations with CRT status, rather than with corticospinal tract status. These findings suggest that CRT status appears to be clinically important for gait function and trunk stability in pediatric patients and DTT can help assess CRT status in pediatric patients with gait dysfunction.

关键词： nerve regeneration corticoreticular tract corticospinal tract gait trunk diffusion tensor Trunk Control Measurement Scale Functional Ambulation Category Growth Motor Function Classification System cerebral palsy motor neural regeneration

Magnesium sulfate and fetal neuroprotection: overview of clinical evidence

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Neural Regeneration Research 2018年第12期13卷 2044-2049页

作者： Clément Chollat Stéphane Marret Institut National de la Santé et de la Recherche Médicale U1245 Genetics and Pathophysiology of Neurodevelopmental Disorders Team 4Neovasc Institute of Research and Innovation in Biomedicine Rouen School of Medicine Normandy University Department of Neonatal Intensive Care Port Royal University Hospital Department of Neonatal Pediatrics and Intensive Care and Neuropediatrics Charles-Nicolle University Hospital

Antenatal administration of magnesium sulfate is an important part of the neuroprotective strategy for preterm infants. Strong evidence from five randomized controlled trials and five meta-analyses has demonstrated that magnesium sulfate, when administered before preterm delivery, significantly reduces the risk of cerebral palsy at two years. Through secondary analyses of randomized controlled trials and other original clinical studies, this state-of-the-art review highlights the absence of serious adverse effects in both pregnant women and neonates, as well as the impact of maternal body mass index and preeclamptic status on the maternal and neonatal magnesium levels, which could influence the magnitude of the neuroprotective effect. Although antenatal magnesium sulfate is a cost-effective strategy, some practice surveys have demonstrated that the use of magnesium sulfate is not sufficient and that its use is heterogeneous, differing among different maternity wards. Since 2010, an increasing number of obstetrical societies have recommended its use to improve the neurological outcomes of preterm infants, especially the International Federation of Gynecology and Obstetrics and World Health Organization in 2015, and France in 2017. Considering the neuroprotective impact of magnesium sulfate when administered before delivery, postnatal administration should be considered, and its effects should be assessed using randomized controlled trials.

关键词： magnesium sulfate preterm birth neuroprotection cerebral palsy neurodevelopment international recommendations clinical studies meta-analysis preeclampsia cost-effectiveness

Virtual reality interface devices in the reorganization of neural networks in the brain of patients with neurological diseases

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Neural Regeneration Research 2014年第8期9卷 888-896页

作者： Valeska Gatica-Rojas Guillermo Méndez-Rebolledo Laboratory of Human Motor Control Faculty of Health SciencesUniversity of Talca Laboratory of Human Motor Control School of KinesiologyFaculty of Health SciencesUniversity of Talca

Two key characteristics of all virtual reality applications are interaction and immersion. Systemic interaction is achieved through a variety of multisensory channels （hearing, sight, touch, and smell）, permitting the user to interact with the virtual world in real time. Immersion is the degree to which a person can feel wrapped in the virtual world through a defined interface. Virtual real- ity interface devices such as the Nintendo~ Wii and its peripheral nunchuks-balance board, head mounted displays and joystick allow interaction and immersion in unreal environments created from computer software. Virtual environments are highly interactive, generating great activation of visual, vestibular and proprioceptive systems during the execution of a video game. In addi- tion, they are entertaining and safe for the user. Recently, incorporating therapeutic purposes in virtual reality interface devices has allowed them to be used for the rehabilitation of neurological patients, e.g., balance training in older adults and dynamic stability in healthy participants. The improvements observed in neurological diseases （chronic stroke and cerebral palsy） have been shown by changes in the reorganization of neural networks in patients＇ brain, along with better hand function and other skills, contributing to their quality of life. The data generated by such studies could substantially contribute to physical rehabilitation strategies.

关键词： nerve regeneration virtual reality virtual environment virtual reality exposuretherapy rehabilitation stroke postural balance cerebral palsy aged review nintendo wii balanceboard neural regeneration

Efficient Gait Analysis Using Deep Learning Techniques

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Computers, Materials & Continua 2023年第3期74卷 6229-6249页

作者： K.M.Monica R.Parvathi School of Computer Science and Engineering Vellore Institute of TechnologyChennai600117India

Human Activity Recognition(HAR)has always been a difficult task to *** is mainly used in security surveillance,human-computer interaction,and health care as an assistive or diagnostic technology in combination with other technologies such as the Internet of Things(IoT).Human Activity Recognition data can be recorded with the help of sensors,images,or *** daily routine-based human activities such as walking,standing,sitting,etc.,could be a difficult statistical task to classify into categories and hence 2-dimensional Convolutional Neural Network(2D CNN)MODEL,Long Short Term Memory(LSTM)Model,Bidirectional long short-term memory(Bi-LSTM)are used for the *** has been demonstrated that recognizing the daily routine-based on human activities can be extremely accurate,with almost all activities accurately getting recognized over 90%of the ***,because all the examples are generated from only 20 s of data,these actions can be recognised *** from classification,the work extended to verify and investigate the need for wearable sensing devices in individually walking patients with cerebral palsy(CP)for the evaluation of chosen Spatio-temporal features based on 3D foot ***-control research was conducted with 35 persons with CP ranging in weight from 25 to 65 *** Motion Capture(OMC)equipment was used as the referral method to assess the functionality and quality of the foot-worn *** average accuracy±precision for stride length,cadence,and step length was 3.5±4.3,4.1±3.8,and 0.6±2.7 cm *** cadence,stride length,swing,and step length,people with CP had considerably high inter-stride ***-worn sensing devices made it easier to examine Gait Spatio-temporal data even without a laboratory set up with high accuracy and precision about gait abnormalities in people who have CP during linear walking.

关键词： Human activity recognition neural networks gait analysis wearable sensors kinetic analysis cerebral palsy

Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study

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Neural Regeneration Research 2013年第5期8卷 474-478页

作者： Ah Young Lee Sung Ho Jang Sang Seok Yeo Ensil Lee Yun Woo Cho Su Min Son Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Pediatrics College of Medicine Yeungnam University

We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients＇ functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg＇s balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected.

关键词： neural regeneration neuroimaging Dandy-Walker malformation cerebellar peduncle ataxia cerebral palsy functional ambulation category Berg's balance scale fractional anisotropy apparent diffusion coefficient diffusion tensor tractography diffusion tensor imaging grants-supported paper photographs-containing paper neuroregeneration

Ocular alignment and results of strabismus surgery in neurologically impaired children

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 113-115页

作者： igdem lk Can Sibel Polat Meryem Yasar Bayazit ilhan Ayse Gl Koak Altintas Ministry of Health Ulucanlar Eye Education and Research Hospital 3rd Clinic AnkaraTurkey

AIM:To evaluate ocular alignment and surgical results of strabismus surgery in neurologically impaired children.· METHODS:Files of 33 neurologically impaired squint children were *** patients had cerebral palsy(CP),4 had CP with mental retardation,therest had mental-motor retardation of unknown *** refractions,type and angle of strabismus,surgeries performed were recorded.· RESULTS:Mean follow-up was 34.0±16.5 ***-three patients had esodeviation,the remaining had *** 19 patients,angle of deviations measured at different visits were highly *** patients with stable angle of deviations or with unstable but high angle deviations had horizontal muscle *** horizontal deviation decreased from 43.75±10,69 D to 12.83±8.38D with surgery.· CONCLUSION:In neurologically impaired strabismic children,surgery is effective in patients with stable deviations or unstable but high angle *** for surgery should be made after a long follow up period.

关键词： cerebral palsy mental-motor retardation strabismus

Rectal prolapse in a 30-year-old bladder stone male patient:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3317-3322页

作者： Hong-Xiang Ding Jia-Guo Huang Chao Feng Sheng-Cheng Tai Department of Urology Affiliated Xiaoshan HospitalHangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina School of Medicine Hangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Rectal prolapse occurs most commonly in children and middle-aged and elderly women and is relatively rare in young men and is occasionally caused by bladder *** rectal prolapse,bilateral hydronephrosis,and renal insufficiency caused by bladder stones are rare in a 30-year-old *** SUMMARY We report the case of a 30-year-old male patient with cerebral palsy who presented with a large bladder stone that resulted in severe rectal prolapse,bilateral hydronephrosis,and renal *** a definitive diagnosis,the bladder stone was successfully removed,and his kidney function returned to *** assessed the patient’s nutritional status and stone composition and concluded that the main cause was *** Rectal prolapse is a rare clinical manifestation of bladder stones,particularly in young *** palsy patients are a vulnerable group in society because of their intellectual disabilities and communicative ***,besides taking care of their daily diet,abnormal signs in their bodies should receive the doctors’attention in a timely manner.

关键词： Bladder stone Rectal prolapse cerebral palsy Malnutrition Case report