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Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response

引用

Animal Nutrition 2022年第4期11卷 402-412页

作者： Shao-Shuai Bi Milton Talukder Hai-Tao Jin Mei-Wei Lv Jing Ge Cong Zhang Jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China College of Biotechnology and Pharmaceutical Engineering of West Anhui University Lu’an 237012China Department of Physiology and Pharmacology Faculty of Animal Science and Veterinary MedicinePatuakhali Science and Technology UniversityBarishal8210Bangladesh Quality and Safety Institute of Agricultural Products Heilongjiang Academy of Agricultural SciencesHarbin 150010China College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin 150030China

This study aims to investigate the role of metal regulatory transcription factor 1(MTF1)-mediated metal response in cadmium(Cd)-induced cerebellar injury,and to evaluate the antagonistic effects of nanoselenium(Nano-Se)against Cd toxicity.A total of 80 chicks(1 d old,male,Hy-Line Variety White)were randomly allocated to 4 treatment groups for 3 months:the control group(fed with a basic diet,n=20),the Nano-Se group(basic diet with 1 mg/kg nano-Se 1 mg/kg Nano-Se in basic diet,n=20),the NanoSe+Cd group(basic diet with 1 mg/kg Nano-Se and 140 mg/kg Cd Cl_(2),n=20)and the Cd group(basic diet with 140 mg/kg Cd Cl_(2),n=20).The results of the experiment showed that the Purkinje cells were significantly decreased with their degradation and indistinct nucleoli after Cd ***,exposure to Cd caused a significant accumulation of Cd and ***,the contents of Se,iron,and zinc were decreased,thereby disturbing the metal homeostasis in the *** Cd exposure also resulted in high levels of malondialdehyde(MDA)and down regulation of selenoprotein ***,the expressions of MTF1,metallothionein 1(MT1),MT2,zinc transporter 3(ZNT3),ZNT5,ZNT10,zrt,irt-like protein 8(ZIP8),ZIP10,transferrin(TF),ferroportin 1(FPN1),ATPase copper transporting beta(ATP7B),and copper uptake protein 1(CTR1)were inhibited by Cd ***,all these changes were significantly alleviated by the supplementation of *** study proved that Cd could disorder metal homeostasis and induce oxidative stress,whereas Nano-Se could relieve all these negative effects caused by Cd via activating the MTF1-mediated metal response in the cerebellum of chicken.

关键词： Nano-selenium Cadmium Selenoprotein transcriptome MTF1-mediated metal response cerebellar injury

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