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Role of NMDARs during the sensory stimulation-evoked field potential responses in mouse cerebellar cortical molecular layer

Role of NMDARs during the sensory stimulation-evoked field p...

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中国神经科学学会第十二届全国学术会议

作者： Fang-Ling Xuan Ke-Ming Zhang Bing-Xue Li Li-Na Cui De-Lai Qiu Chun-Ping Chu Cellular Function Research Center Yanbian University

Objective In mammalian cerebellar cortex, NMDARs are found existed on the membrane of granule cells（GC）, terminals of parallel fibers（PF）, molecular layer interneurons（MLI） and climbing fiber-Purkinje cell（PC） synapses, but the functional NMDARs are absence in the membrane of the adult PCs. We previously found that the air-puff stimulation on ipsilateral whisker pad evoked a sequence of transient tiny excitation response followed by strong inhibitory response in cerebellar molecular layer via mossy fiber pathway. In the present study, we investigated the role of NMDARs during the air-puff stimulation evoked field potential responses in cerebellar molecular layer of urethane-anesthetized mice. Methods Local field potential recordings from the cerebellar molecular layer were performed with an Axopatch-200 B amplifier. Sensory stimulation was performed using air-puff（60 ms, 60 psi） of ipsilateral whisker pad through a 12-gauge stainless tube connected with a pressurized injection system. The airpuff stimulations were controlled by a personal computer, which were synchronized with the electrophysiological recordings and delivered at 0.05 Hz through a Master 8 controller. All chemicals were applied to the cerebellar surface at 0.4 ml/min in ACSF. Results（1） Administration of NMDA affected the dynamic properties of sensory stimulation-evoked P1 in mouse cerebellar molecular layer, which expressed decreases in decay time, half-width and area under curve（AUC） of P1.（2） Application of NMDA induced significant increases in the decay time, half-width and AUC values of the facial stimulation-evoked excitatory responses（N1） in cerebellar molecular layer. However, NMDA did not significantly affect the amplitude, half-amplitude of N1 and rise time of N1.（3） Application an NMDAR blocker, D-APV（250 μM） abolished the facial stimulation-evoked GABAergic inhibitory components（P1） in mouse cerebellar molecular layer.（4） Blockade of NMDARs did not significantly change the amplitude and h

关键词： cerebellar cortical molecular layer field potential recording NMDA receptors air-puff stimulation GABAergic responses parallel fiber

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