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Fifteen acute retrobulbar optic neuritis associated with COVID-19:A case report and review of literature

World Journal of Clinical Cases 2024年第21期12卷 4827-4835页

作者： Rong-Rong Li Bao-Ming Zhang Su-Ran Rong Huan Li Peng-Fei Shi Yun-Chang Wang Hebei Provincial Key Laboratory of Ophthalmology Hebei Provincial Clinical Research Center for Eye DiseasesHebei Eye HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND A subtype of the Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is suggested to be responsible for the outbreak in Northern China since the quarantine was lifted in December *** coronavirus disease 2019 virus is primarily responsible for the development of respiratory illnesses,however,it can present a plethora of symptoms affecting a myriad of body *** virus has been theorized to be linked to demyelinating lesions of the peripheral and central nervous system including transverse myelitis and acute retrobulbar optic neuritis(ARON).For example,magnetic resonance imaging(MRI)of the orbit and brain showed enlargement of the retrobulbar intraorbital segments of the optic nerve with high T2 signal,and no abnormalities were seen in the brain *** this case series,we analyzed the connection between SARSCoV-2 infection and the onset of *** SUMMARY Fifteen patients,and a teenage boy who did not have any pre-existing ocular or demyelinating diseases suddenly experienced a loss of vision after SARS-CoV-2 *** patients expressed a central scotoma and a fever as the primary *** results of the fundus photography were found to be ***,the automated perimetry and MRI scans showed evidence of some typical *** of the 15 patients diagnosed with ARON after SARS-CoV-2 infection,only one individual tested positive for the aquaporin-4 *** Direct viral invasion of the central nervous system and an immune-related process are the two primary causes of SARS-CoV-2-related ARON.

关键词： SARS-CoV-2 COVID-19 Acute retrobulbar optic neuritis central scotoma Li RR et al.ARON associated with COVID-19

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