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central nervous system tumors and three-dimensional cell biology: Current and future perspectives in modeling

World Journal of Stem Cells 2021年第8期13卷 1112-1126页

作者： Zaki Abou-Mrad Jolie Bou Gharios Maya M Moubarak Ahmad Chalhoub Charbel Moussalem Hisham F Bahmad Wassim Abou-Kheir Department of Anatomy Cell Biology and Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 1107-2020Lebanon Division of Neurosurgery Department of SurgeryAmerican University of Beirut Medical CenterBeirut 1107-2020Lebanon Arkadi M.Rywlin M.D.Department of Pathology and Laboratory Medicine Mount Sinai Medical CenterMiami BeachFL 33140United States

central nervous system(CNS)tumors are a variety of distinct neoplasms that present multiple challenges in terms of treatment and ***,the most common primary tumor in adults,is associated with poor survival and remains one of the least treatable *** tumors are highly heterogenous and complex in their *** to this complexity,traditional cell culturing techniques and methods do not provide an ideal recapitulating model for the study of these tumors’behavior in ***-dimensional models lack the spatial arrangement,the heterogeneity in cell types,and the microenvironment that play a large role in tumor cell behavior and response to ***,scientists have turned towards three-dimensional culturing methods,namely spheroids and organoids,as they have been shown to recapitulate tumors in a more faithful manner to their in vivo ***,tumor-on-a-chip systems have lately been employed in CNS tumor modeling and have shown great potential in both studying the pathophysiology and therapeutic *** this review,we will discuss the current available literature on in vitro threedimensional culturing models in CNS tumors,in addition to presenting their advantages and current *** will also elaborate on the future implications of these models and their benefit in the clinical setting.

关键词： central nervous system tumors Glioblastoma Three-dimensional modelling Spheroids Organoids

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Analysis of Present Situation and Influencing Factors of Coping Methods by Parents of Children with central nervous system tumors

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World Journal of Neuroscience 2020年第4期10卷 206-215页

作者： Lan Bai Qinqin Zhao Chunju Xiao Zhihuan Zhou Neurosurgery Department Sun Yat-sen University Cancer Center Guangzhou China

Background: central nervous system (CNS) tumors are the most common solid tumors among children. Due to the severity of the tumors and the complexity of therapeutic regimes, it is very important to examine whether par... 详细信息

Background: Central nervous system (CNS) tumors are the most common solid tumors among children. Due to the severity of the tumors and the complexity of therapeutic regimes, it is very important to examine whether parents of the children with CNS tumors have positive coping methods against the disease. This study aims to analyze the coping methods of the parents and the factors influencing the methods. Methods: A total of 108 parents of brain cancer children admitted from January 2019 to September 2020 were selected as subjects. After collecting the general information of the parents, they were studied using the Coping Health Inventory for Parents (CHIP, Chinese version). Additionally, their coping pattern and the influencing factors were analyzed. Results: The average scores of the three subscales of the CHIP were (4.25 ± 0.939), (3.11 ± 1.205) and (3.60 ± 1.187), respectively. Univariate analysis showed that parents’ education, medical payment methods, places of residence and economic concerns were the main factors influencing the coping methods (all P Conclusions: Healthcare staff should fully evaluate the coping methods adopted by the parents having children with CNS tumors, take targeted nursing measures accordingly, and assist the parents in seeking social support and learning disease-related knowledge. In addition, public education on disease is equally important.

关键词： Coping Methods Parents Children central nervous system tumors

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Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital

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Chinese Neurosurgical Journal 2022年第3期8卷 188-194页

作者： Zhi-ming Liu Chih-yi Liao Heng Zhang Zhe Han Jun-mei Wang Zhen-yu Ma Chun-de Li Jian Gong Wei Liu Tao Sun Yong-ji Tian Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Center of Brain TumorBeijing Institute for Brain DisordersBeijing Key Laboratory of Brain TumorBeijingChina Department of Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina

Background:To describe the epidemiological characteristics of central nervous system(CNS)tumors in children,based on the neurosurgery department of Beijing Tiantan ***:From January 2015 to December 2019,3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization(WHO)classification of *** were 0 to 15 years *** analyzed age-related gender preferences,tumor locations,and the histological grades of the *** addition,the epidemiological characteristics of the five most common intracranial tumors were compared to the previous ***:In this study,intracranial and spinal tumors account for 96.4%(3066)and 3.6%(114)of all tumors,with a preponderance of supratentorial tumors(57.9%).Among all pediatric patients,low-grade tumors comprise 67.1%(2135).The integral gender ratio of males to females is 1.47:1 and the average age of patients is 7.59 years *** five most common intracranial tumors are craniopharyngioma(15.4%),medulloblastoma(14.3%),pilocytic astrocytoma(11.8%),diffuse astrocytoma(9.8%),and anaplastic ependymoma(4.8%).Conclusions:Due to the lack of national data on childhood brain tumors,we used a large nationally representative population sample based on the largest pediatric neurosurgery center in *** analyzed the data of the past 5 years,reflecting the incidence of CNS tumors in Chinese children to a certain extent,and laying a data foundation for subsequent clinical studies.

关键词： Epidemiology central nervous system tumors Pediatric World Health Organization classification

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Cell Replication and Angiogenesis in central nervous system tumors and Their Relationship with the Expression of Tissue Prolactin and Hyperprolactinemia

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Open Journal of Pathology 2012年第3期2卷 50-57页

作者： Denise M.D.Abech Júlia F.S.Pereira-Lima Carolina G.S.Leaes Rosalva T.Meurer Ligia M.Barbosa-Coutinho Nelson P.Ferreira Miriam C.Oliveira Center for Neuroendocrinology Universidade Federal de Ciencias da Saúde de Porto Alegre(UFCSPA)Porto AlegreBrazil

This study aimed to assess the effect of intracellular prolactin (ICPRL) and hyperprolactinemia on cell replication, using an immunohistochemical (IHC) technique for Ki-67 and Mcm-2, and angiogenesis, using IHC for endoglin CD-105, in central nervous system (CNS) tumors. This cross-sectional study included 79 cases of surgically excised primary CNS tumors of neuroepithelial origin (41.8% of all cases: 10.2% astrocytomas, 24% glioblastomas and 7.6% oligodendrogliomas) and meningeal origin (58.2% of all cases). Ki-67 and Mcm-2 indexes were calculated as a percentage of marked cells. The medians for Ki-67 and Mcm-2 indexes were significantly lower in meningiomas than in glioblastomas (p S = 0.60) replication markers. There were no significant differences in vascular density between the different histological types. Immunohistochemistry for ICPRL was positive in 45.6% of the tumors. Serum prolactin (PRL) was elevated in 30.6% of the cases. Multiple regression analysis revealed no important correlation of ICPRL and serum PRL on Ki-67 and Mcm-2 indexes or vascular density. The analysis of the combined impact of ICPRL and serum PRL variables revealed a trend towards an increase in microvessel density in tumor tissue and a significant increase in cell replication markers (p = 0.009 for Ki-67 and p = 0.05 for Mcm-2). PRL in tumor tissue may be one of the modulating factors of cell proliferation in the CNS.

关键词： Ki-67 Antigen Mcm-2 Protein Human Endoglin Protein Prolactin central nervous system tumors

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