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Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules

引用

Bioactive Materials 2021年第8期6卷 2303-2314页

作者： Na Li Wei Cui Peifang Cong Jie Tang Yong Guan Caihao Huang Yunen Liu Chengzhong Yu Rui Yang Xing Zhang Institute of Metal Research Chinese Academy of SciencesShenyangLiaoning110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefeiAnhui230026China Department of Emergency Medicine General Hospital of Northern Theater CommandShenyangLiaoning110016China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefeiAnhui230029China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD4072Australia

Amorphous calcium phosphate(ACP)has been widely found during bone and tooth biomineralization,but the meta-stability and labile nature limit further biomedical *** present study found that the chelation of polyacrylic acid(PAA)molecules with Ca^(2+)ions in Mg-ACP clusters(~2.1±0.5 nm)using a biomineralization strategy produced inorganic-organic Mg-ACP/PAA hybrid nanoparticles with better thermal ***-ACP/PAA hybrid nanoparticles(~24.0±4.8 nm)were pH-responsive and could be efficiently digested under weak acidic conditions(pH 5.0-5.5).The internalization of assembled Mg-ACP/PAA nanoparticles by MC3T3-E1 cells occurred through endocytosis,indicated by laser scanning confocal microscopy and cryo-soft X-ray *** results showed that cellular lipid membranes remained intact without pore formation after Mg-ACP/PAA particle *** assembled Mg-ACP/PAA particles could be digested in cell lysosomes within 24 h under weak acidic conditions,thereby indicating the potential to efficiently deliver encapsulated functional *** the in vitro and in vivo results preliminarily demonstrated good biosafety of the inorganic-organic Mg-ACP/PAA hybrid nanoparticles,which may have potential for biomedical applications.

关键词： Inorganic-organic hybrid pH responsive ACP clusters cellular degradation Cryo-soft X-ray tomography

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