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Direct Correlation among Telomere Length, cellular aging, and Rejuvenation Effects of Honey Child Powder

Journal of Biosciences and Medicines 2024年第7期12卷 55-70页

作者： Naofumi Shiomi Keiko Watanabe Yuki Fujiwara Takae Yamasaki Hideto Matsuyama Research Center for Membrane and Film Technology Kobe University Kobe Japan School of Human Sciences Kobe College Nishinomiya Japan Department of Chemical Science and Engineering Kobe University Kobe Japan

Purpose: Telomere length (TL) is an indicator of age;however, hormonal influences complicate individual aging. It remains unclear whether TL shortening is a direct factor in both individual and cellular aging. Therefore, we examined the direct relationship between TL and cellular senescence at the cellular level. Methods: Telomerase activity, TL, and gene expression were measured in cultured human lung-, fetal-, and skin-derived fibroblasts, human skin keratinocytes, and telomerase reverse transcriptase (TERT) gene-immortalized cells using detection kits, Cawthon’s method, and reverse transcription-quantitative polymerase chain reaction, respectively. Novel substances that elongate telomeres were screened to confirm cell rejuvenation effects. Results: Long-term cell culture of TIG-1-20 normal human fibroblasts resulted in TL shortening, decreased division rate, and senescence progression, whereas in OUMS-36T-2 cells, TL elongation via TERT gene transfer increased the division rate, reduced endoplasmic reticulum stress, and upregulated genes associated with young individuals, indicating that cellular rejuvenation occurs via TL elongation. In addition, a honey child powder (HCP) extract was found through screening, and the HCP extract strongly suppressed the menin gene, resulting in increased telomerase activity and extended cell lifespan. Upon addition of the HCP extract to skin fibroblasts, gene expression of moisturizing components, including collagen, hyaluronic acid, and elastin, increased, and exhibited a rejuvenating effect with an increase in elastin amount. Conclusions: TL elongation or shortening is involved in cell proliferation rate and cellular aging, and TL elongation rejuvenates cells. In addition, HCP extract has a rejuvenating effect on cells and is expected to be a rejuvenating compound.

关键词： Telomere cellular aging Telomerase Reverse Transcriptase Gene Rejuvenation Honey Child Powder

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The effect of cellular aging on the dynamics of spiral waves

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Chinese Physics B 2014年第12期23卷 97-102页

作者：邓敏艺陈茜琼唐国宁 College of Physical Science and Technology Guangxi Normal University

cellular aging can result in deterioration of electrical coupling, the extension of the action potential duration, and lower excitability of the cell. Those factors are introduced into the Greenberg–Hastings cellular automaton model and the effects of the cellular aging on the dynamics of spiral waves are studied. The numerical results show that a 50% reduction of the coupling strength of aging cells has a little influence on spiral waves. If the coupling strength of aging cells equals zero, the ability for the medium to maintain spiral waves will be reduced by approximately 50% when the aging cell ratio increases from 0 to 0.5, where the reduction of cell excitability plays a major role in inducing disappearance of spiral waves. When the relevant parameters are properly chosen, the cellular aging can lead to the meandering of spiral waves,the emergence of the binary spiral waves, and even the disappearance of spiral waves via the stopping rotation or shrinkage of wave. Physical mechanisms of the above phenomena are analyzed briefly.

关键词： discrete excitable medium Greenberg–Hastings model spiral wave cellular aging

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Epigenetics recording varied environment and complex cell events represents the origin of cellular aging

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第7期20卷 550-562页

作者： Xue-jun GUO Dong YANG Xiang-yuan ZHANG State Key Laboratory of Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Gene Engineering and Biotechnology Beijing Key Laboratory College of Life SciencesBeijing Normal UniversityBeijing 100875China

Although a relationship between epigenetics and aging phenotypic changes has been established,a theoretical explanation of the intrinsic connection between the epigenetics and aging is *** this essay,we propose that epigenetic recording of varied cell environment and complex history could be an origin of cellular *** epigenetic modifications,the environment and historical events can induce the chromatin template into an activated or repressive accessible structure,thereby shaping the DNA template into a spectrum of chromatin *** inner nature of diversity and conflicts born by the cell environment and its historical events are hence recorded into the chromatin *** could result in a dissipated spectrum of the chromatin state and chaos in overall gene *** unavoidable degradation of epigenome entropy,similar to Shannon entropy,would be consequently *** resultant disorder in epigenome,characterized by corrosion of epigenome entropy as reflected in chromatin template,can be stably memorized and propagated through cell ***,the hysteretic nature of epigenetics responding to the emerging environment could exacerbate the degradation of epigenome *** well as stochastic errors,we propose that outside entropy(or chaos) derived from the varied environment and complex cell history,gradually input and imprinted into the chromatin via epigenetic modifications,would lead inevitably to cellular aging,the extent of which could be aggravated by hysteresis of epigenetics without error erasing and correction.

关键词： Epigenetics Environment Cell event cellular aging Epigenome entropy DNA methylation

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