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Microbe social skill:the cell-to-cell communication between microorganisms

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Science Bulletin 2017年第7期62卷 516-524页

作者： Xi Zhao Xiong Liu Xin Xu Yu V.Fu State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of Sciences Savaid Medical School University of Chinese Academy of Sciences

Although microbes primarily are single-cell organisms,they are not isolated *** use various means to communicate with one *** on the communication,microbes establish a social interaction with their neighbors in a specific ecological niche,and cooperative behaviors are normally performed to provide benefits on the population and species *** the microbiome era,in order to better understand the behaviors of microbes,deep understanding of the social communication between microbes hence becomes a key to interpret microbe *** we summarize the molecular mechanisms that underlie the cell-to-cell communication in prokaryotic and eukaryotic microorganisms,the recent discoveries and novel technologies in understanding the interspecies and interkingdom communication,and discuss new concepts of the sociomicrobiology.

关键词： cell-to-cell communication Sociomicrobiology Microbial collective behavior Quorum sensing

cell-to-cell communication between Arabidopsis female gametes

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Cell-to-cell communication between Arabidopsis female gamete...

Effective methods for isolation and purification of extracellular vesicles from plants

从植物科学到农业发展——2012全国植物生物学大会

作者： Jian-Jun Wu,Xiong-Bo Peng,Wen-Wei Li,Rui-He,Hai-Ping Xin,Meng-Xiang Sun~* College of Life Science,Wuhan University,Wuhan,China,430072.

Gametic specification is a key step in fertilization and ***-to-cell communication in embryo sacs is thought to regulate the development of female gametes in flowering plants,but the details remain poorly ***,we report a novel gene, GAMETE cell DEFECTIVE 1(GCD1) that expressed at high levels in gametophytes and is essential for final maturation of the female *** Arabidopsis gcdl mutants,we found that final maturation of the egg and central cells is not required for double fertilization but is necessary for embryogenesis initiation and endosperm development. Furthermore,a previously unrecognized,mitochondrion-dependent signal originating from central and egg cells reciprocally promotes maturation of the partner(egg or central) cell. This signal controls the final maturation of egg and central cells necessary for embryogenesis initiation and early endosperm *** findings confirm that cell-to-cell communication is important in functional specification of female gametic cells and demonstrate the critical role of female gametic maturation in seed setting.

关键词： cell-to-cell communication gamete embryogenesis endosperm Arabidopsis

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Journal of Integrative Plant Biology 2021年第12期63卷 2020-2030页

作者： Yifan Huang Shumei Wang Qiang Cai Hailing Jin State Key Laboratory of Hybrid Rice College of Life ScienceWuhan UniversityWuhan 430072China Hubei Hongshan Laboratory Wuhan 430072China Department of Microbiology and Plant Pathology and Center for Plant cell Biology Institute for Integrative Genome BiologyUniversity of CaliforniaRiversideCA 92507USA

Plant extracellular vesicles(EVs)play critical roles in the cross-kingdom trafficking of molecules from hosts to interacting microbes,most notably in plant defense ***,the isolation of pure,intact EVs from plants remains challenging.A variety of methods have been utilized to isolate plant EVs from apoplastic washing fluid(AWF).Here,we compare published plant EV isolation methods,and provide our recommended method for the isolation and purification of plant *** method includes a detailed protocol for clean AWF collection from Arabidopsis thaliana leaves,followed by EV isolation via differential *** further separate and purify specific subclasses of EVs from heterogeneous vesicle populations,density gradient ultracentrifugation and immunoaffinity capture are then *** found that immunoaffinity capture is the most precise method for specific EV subclass isolation when suitable specific EV biomarkers and their corresponding antibodies are ***,this study provides a guide for the selection and optimization of EV isolation methods for desired downstream applications.

关键词： cell-to-cell communication extracellular vesicles isolation methods plants interacting with pathogens

Emerging role of ER quality control in plant cell signal perception

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Protein & cell 2012年第1期3卷 10-16页

作者： Hong-Ju Li Wei-Cai Yang State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

The endoplasmic reticulum quality control(ER-QC)is a conserved mechanism in surveillance of secreted signaling factors during cell-to-cell communication in *** data show that the ER-QC plays important roles in diverse cell-to-cell signaling processes during immune response,vegetative and reproductive development in *** tube guidance is a precisely guided cell-cell communication process between the male and female gametophytes during plant ***,the female signal has been identified as small secreted peptides,but how the pollen tube responds to this signal is still *** this review,we intend to summarize the role of ER-QC in plants and discuss the recent advances regarding our understanding of the mechanism of pollen tube response to the female signals.

关键词： cell-to-cell communication pollen tube guidance gametophyte ER quality control

Gut microbiota:a new player in regulating immune-and chemo-therapy efficacy

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Cancer Drug Resistance 2020年第3期3卷 356-370页

作者： Simone Anfossi George A.Calin Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA. Center for RNA Interference and Non-coding RNAs The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA.

Development of drug resistance represents the major cause of cancer therapy failure,determines disease progression and results in poor prognosis for cancer *** mechanisms are responsible for drug *** genetic modifications of cancer cells induce the alteration of expression of gene controlling specific pathways that regulate drug resistance:drug transport and metabolism;alteration of drug targets;DNA damage repair;and deregulation of apoptosis,autophagy,and pro-survival *** the other hand,a complex signaling network among the entire cell component characterizes tumor microenvironment and regulates the pathways involved in the development of drug *** microbiota represents a new player in the regulation of a patient’s response to cancer therapies,including chemotherapy and *** particular,commensal bacteria can regulate the efficacy of immune checkpoint inhibitor therapy by modulating the activation of immune responses to *** bacteria can also regulate the efficacy of chemotherapeutic drugs,such as oxaliplatin,gemcitabine,and ***,it has been shown that such bacteria can produce extracellular vesicles(EVs)that can mediate intercellular communication with human host ***,bacterial EVs carry RNA molecules with gene expression regulatory ability that can be delivered to recipient cells of the host and potentially regulate the expression of genes involved in controlling the resistance to cancer *** the other hand,host cells can also deliver human EVs to commensal bacteria and similarly,regulate gene *** intercellular communication between commensal bacteria and host cells may thus represent a novel research area into potential mechanisms regulating the efficacy of cancer therapy.

关键词： Gut microbiota resistance chemotherapy immunotherapy immune checkpoint inhibitor extracellular vesicles miRNAs cell-to-cell communication

Activated vascular endothelia regulate invasion of glioma cells through expression of fibronectin

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Chinese Medical Journal 2010年第13期123卷 1754-1761页

作者： LIN Zhi-xiong YANG Li-juan HUANG Qiang FU Jin Department of Neurosurgery the First Affiliated Hospital Fujian Medical University Fuzhou Fujian 350005 China Department of Pharmacology Fujian Medical University Fuzhou Fujian 350004 China Department of Neurosurgery the Second Hospital Suzhou University Suzhou Jiangsu 215004 China Department of Pharmacology the School of Medicine Xiamen University Xiamen 361005 China Department of Pharmacology University of California Irvine USA

Background Previous researches have indicated that glioma invasion may occur within a tumor-host microecology, and that fibronectin may be involved in glioma invasion as an important component of the extracellular matrix. However, how the interaction between tumor cells and vascular endothelial cells affects glioma invasion is poorly understood. The aim of this study was to investigate the effects of the interaction between tumor cells and vascular endothelial cells on glioma invasion, and the relationship of this interaction to fibronectin. Methods The localization of fibronectin in different brain astrocytoma tissues was determined by immunohistochemistry Then, vascular endothelial cells and glioma cells were co-cultured in a Transwell co-culturing system. Fibronectin expression was detected by reverse transcriptase-polymerase chain reaction, immunocytochemistry, and enzyme-linked immunosorbent assay. Additionally, the influence of the interaction between tumor cells and vascular endothelial cells on glioma cell invasion was determined by an in vitro rapid invasion test. Results In brain astrocytoma tissues, fibronectin was present on the endothelial cells, in the extracellular matrix. Fibronectin expression was greater in higher grade tumors than in lower grade tumors. The interaction of glioma cells and vascular endothelial cells in vitro induced fibronectin release from vascular endothelial cells, which in turn stimulated glioma cell migration. This effect was inhibited by fibronectin blocking antibody. Conclusion Glioma cells may induce vascular epithelial cells to express fibronectin, and in turn fibronectin could promote glioma cell invasion.

关键词： glioma fibronectin neoplasm invasiveness tumor-host microecology cell-to-cell communication