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World Journal of Stem cells 2020年第12期12卷 1553-1575页

作者： Nikolaos Kokkorakis Maria Gaitanou Laboratory of cellular and Molecular Neurobiology-Stem cells Hellenic Pasteur InstituteAthens 11521Greece

Dual-specificity tyrosine phosphorylation-regulated kinase 1B(DYRK1B),also known as minibrain-related kinase(MIRK)is one of the best functionally studied members of the DYRK kinase *** comprise a family of protein kinases that are emerging modulators of signal transduction pathways,cell proliferation and differentiation,survival,and cell *** were found to participate in several signaling pathways critical for development and cell *** this review,we focus on the DYRK1B protein kinase from a functional point of view concerning the signaling pathways through which DYRK1B exerts its cell type-dependent function in a positive or negative manner,in development and human *** particular,we focus on the physiological role of DYRK1B in behavior of stem cells in myogenesis,adipogenesis,spermatogenesis and neurogenesis,as well as in its pathological implication in cancer and metabolic ***,understanding of the molecular mechanisms that regulate signaling pathways is of high *** studies have identified a close regulatory connection between DYRK1B and the hedgehog(HH)signaling ***,we aim to bring together what is known about the functional integration and cross-talk between DYRK1B and several signaling pathways,such as HH,RAS and PI3K/mTOR/AKT,as well as how this might affect cellular and molecular processes in development,physiology,and ***,this review summarizes the major known functions of DYRK1B kinase,as well as the mechanisms by which DYRK1B exerts its functions in development and human diseases focusing on the homeostasis of stem and cancer stem cells.

关键词： Dual-specificity tyrosine-regulated kinase 1B Minibrain-related kinase Stem cells Cancer stem cells Quiescence cell proliferation/differentiation cell survival Cancer Hedgehog

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