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cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy

Cancer drug Resistance 2020年第4期3卷 879-911页

作者： Serkan Yaman Uday Chintapula Edgar Rodriguez Harish Ramachandramoorthy Kytai T.Nguyen Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76010USA Joint Bioengineering Program University of Texas Southwestern Medical CenterDallasTX 75235USA

Nanotechnology-based drug delivery platforms have been developed over the last two decades because of their favorable features in terms of improved drug bioavailability and *** recent advancement in nanotechnology platforms,this approach still falls short to meet the complexity of biological systems and diseases,such as avoiding systemic side effects,manipulating biological interactions and overcoming drug resistance,which hinders the therapeutic outcomes of the NP-based drug delivery *** address these issues,various strategies have been developed including the use of engineered cells and/or cell membrane-coated *** membrane receptor profiles and characteristics are vital in performing therapeutic functions,targeting,and homing of either engineered cells or cell membrane-coated nanocarriers to the sites of *** this context,we comprehensively discuss various cell-and cell membrane-based drug delivery approaches towards cancer therapy,the therapeutic potential of these strategies,and the limitations associated with engineered cells as drug carriers and cell membrane-associated drug ***,we review various cell types and cell membrane receptors for their potential in targeting,immunomodulation and overcoming drug resistance in cancer.

关键词： cell membrane-based drug delivery cell-mediated drug delivery membrane receptors drug carriers cancer drug resistance nanoparticles

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