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Role of immune cell interactions in alcohol-associated liver diseases

Liver Research 2024年第2期8卷 72-82页

作者： Xianda Wang Juan Wang Haodong Peng Li Zuo Hua Wang Innovation and Entrepreneurship Laboratory for College Students Anhui Medical UniversityHefeiAnhuiChina Laboratory of Molecular Biology Department of BiochemistrySchool of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina The First School of Clinical Medicine Anhui Medical UniversityHefeiAnhuiChina Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province Anhui Medical UniversityHefeiAnhuiChina Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina

Research on inflammatory response,liver injury,and immune regulation has demonstrated that the intricate interactions among immune cells constitute a critical regulatory *** consumption alters the liver microenvironment,triggering inflammation and immune *** the inhibitory,cooperative,and synergistic effects among lymphocytes and myeloid cells may reveal the core mechanisms of alcohol-associated liver disease(ALD)pathogenesis and identify promising therapeutic *** review seeks to elucidate the intricate and multifaceted interactions among immune cells,encompassing both direct cellular interactions and the secretion of various effector *** is essential to underscore that these interactions have broader and more complex roles in ALD than the activities of individual immune cell *** interactions play a crucial role in mutually regulating one another,thereby preserving the homeostasis of the inflammatory and immune response in the liver *** these immune cell interactions is anticipated to offer a novel approach to the prevention and treatment of ALD.

关键词： Immune cell cell interactions Inflammation Alcohol-associated liver disease(ALD)

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A Brief Review on Hydroxyapatite Nanoparticles interactions with Biological Constituents

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Journal of Biomaterials and Nanobiotechnology 2022年第1期13卷 24-44页

作者： Flávia Carolina Lima Torres Edésia Martins Barros De Sousa Marcelo Fernandes Cipreste Serviç o de Nanotecnologia (SENAN) Centro de Desenvolvimento da Tecnologia Nuclear (CDTN) Belo Horizonte Brazil Faculdade de Farmácia Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil

With the pursuit of new cancer therapies and more effective treatment to diseases in the last decades, nanotechnology has been an important ally for healthcare professionals and patients in critical clinical conditions. Nanomaterials offer an alternative way to deliver toxic chemotherapeutic drugs to specific biological tissues, specific cells or specific microbial beings, resulting in avoidance of strong side effects or resilience to effective drugs. Among these materials, stands out the hydroxyapatite nanoparticles, a ceramic class of calcium phosphates that present chemical and structural similarities with the mineral phase of the human skeleton’s bone matrix, resulting in important biological features, such as biocompatibility, osteoconductive, osteoinduction and osteoaffinity, which led to a lot of scientific researches to apply these nanoparticles for bone diseases diagnosis and therapeutics. Due to the hydroxyapatite biological activities and due to the possibility to promote chemical and physical modifications in these nanoparticles, they can interact with biological cells or microorganisms in different ways, resulting in multiple potentialities to be explored such as apoptosis induction to cancerous cells, osteogenesis promotion, cellular proliferation, angiogenesis and tissue recovery, in addition to promote cell adhesion and cell uptake. Furthermore, chemical and physical modifications, such as surface functionalization, dopant inclusions and radiolabeling process, allow scientists to track the particle activities in biological environments. In the last decades of scientific productions, the literature brings together important data on how hydroxyapatite nanoparticles interact with biological tissues and such data are crucial for the development of more effective therapeutic and diagnostic agents. In the present review, we intend to compile scholarly information to explore the biological relations of nanosized hydroxyapatite with the human cellular enviro

关键词： Biomaterials Nano-Hydroxyapatite cell interactions Chemical Modifications Tissue Engineering Theranostics

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