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Eularian wall film model for predicting dynamic cell culture process to evaluate scaffold design in a perfusion bioreactor

引用

Medicine in Novel Technology and Devices 2022年第1期13卷 12-21页

作者： Ziyu Liu Chunjing Tao Shanshan Yuan Wei Wang Maryam Tamaddon Liqi Ng Hao Huang Xiaodan Sun Chaozong Liu Division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalStanmore HA74LPUK School of Medical Science and Engineering Beihang UniversityChina Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijingChina Department of Cardiology Qingdao Municipal HospitalShandongChina School of Science and Engineering The Chinese University of Hong KongShenzhenChina

In tissue engineering field,it is important to develop a suitable numerical model to evaluate scaffold geometry *** experimental evaluation of the effect of each specific scaffold parameter on tissue regeneration requires large cost and long time *** cell culture is commonly used for generating tissues which could replace damaged tissues.A perfusion bioreactor model is developed which is able to simulate dynamic cell culture,to evaluate scaffold *** wall-film model is used to simulate cell attachment with the assumption that cells could be seen as liquid *** the process of cell attachment,the cells could impinge to a solid surface and form a liquid film which were considered as cell attached on the scaffold *** types of cell-scaffold interactions were involved in numerical models including trap model and Stanton-Rutland(cell impinge model—CIM)*** trap model,all cells impinged the scaffold are seen as *** Stanton-Rutland model,four regimes of cell-scaffold interaction are involved in the cell attachment,including stick,rebound,spread,and splash,and only stick and spread are seen as *** comparison with two different numerical methods,the results showed that CIM model result is more related to the experimental results than trap model,which indicated that four regimes of cell-scaffold interaction occurred in cell attachment *** evaluating two different geometry scaffold's cells seeding by these two models,the results further indicated that this model are able to use for assessing the scaffold design.

关键词： Scaffold structure Computational fluid dynamics cell attachment cell impinge model

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