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Epigenetics recording varied environment and complex cell events represents the origin of cellular aging

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第7期20卷 550-562页

作者： Xue-jun GUO Dong YANG Xiang-yuan ZHANG State Key Laboratory of Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Gene Engineering and Biotechnology Beijing Key Laboratory College of Life SciencesBeijing Normal UniversityBeijing 100875China

Although a relationship between epigenetics and aging phenotypic changes has been established,a theoretical explanation of the intrinsic connection between the epigenetics and aging is *** this essay,we propose that epigenetic recording of varied cell environment and complex history could be an origin of cellular *** epigenetic modifications,the environment and historical events can induce the chromatin template into an activated or repressive accessible structure,thereby shaping the DNA template into a spectrum of chromatin *** inner nature of diversity and conflicts born by the cell environment and its historical events are hence recorded into the chromatin *** could result in a dissipated spectrum of the chromatin state and chaos in overall gene *** unavoidable degradation of epigenome entropy,similar to Shannon entropy,would be consequently *** resultant disorder in epigenome,characterized by corrosion of epigenome entropy as reflected in chromatin template,can be stably memorized and propagated through cell ***,the hysteretic nature of epigenetics responding to the emerging environment could exacerbate the degradation of epigenome *** well as stochastic errors,we propose that outside entropy(or chaos) derived from the varied environment and complex cell history,gradually input and imprinted into the chromatin via epigenetic modifications,would lead inevitably to cellular aging,the extent of which could be aggravated by hysteresis of epigenetics without error erasing and correction.

关键词： Epigenetics Environment cell event cellular aging Epigenome entropy DNA methylation

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