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检索条件"主题词=Cell=neuron"

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Signal integration and coincidence detection by TRPC channels

Signal integration and coincidence detection by TRPC channel...

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第九届全国钙信号和细胞功能研讨会

作者： Michael Xi Zhu Department of Integrative Biology and Pharmacology The University of Texas Health Science Center at HoustonHoustonTexasUSA

＜正＞Transient receptor potential canonical（TRPC）channels play diverse physiological functions and are generally activated following stimulation of phospholipase C,but the precise mechanisms for activation of different TRPC subtypes remain *** ability to sense and distinguish simultaneous activations of multiple signaling events/pathways suggests that TRPCs may serve as coincidence detectors of extra-and intracellular ***,TRPC4,which mediates the major portion of muscarinic agonist-elicited cation currents in intestinal smooth muscles,is activated more

关键词： cell=neuron Method=electrophysiology Topic=TRP channels

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Diversification of L-type Cav1.3 Calcium Channel Function through Alternative Splicing and RNA Editing

Diversification of L-type Cav1.3 Calcium Channel Function th...

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第九届全国钙信号和细胞功能研讨会

作者： Tuck Wah Soong Department of Physiology Yong Loo Lin School of MedicineNational University of Singapore2 Medical DriveSingapore 117597

The proteomic diversity of L-type Cav 1.3 channels can be expanded via posttranscriptional mechanisms such as alternative splicing and RNA ***,we discuss the fine-tuning of Ca

关键词： cell=neuron Method=electrophysiology Topic=calcium channel

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Acute stress induces down-regulation of large-conductance Ca2+-activated potassium channels in the lateral amygdala

Acute stress induces down-regulation of large-conductance Ca...

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第九届全国钙信号和细胞功能研讨会

作者： Yan-yan Guo,Ming-gao Zhao Department of Pharmacology,School of Pharmacy,Fourth Military Medical University,Xi’an 710032,Shaanxi,China.

Large-conductance Ca-activated potassium channels(BKCa)are highly expressed in the lateral amygdala(LA),which is closely involved in assigning stress disorders,but data on their role in the neuronal circuits of stress disorders are limited,In the present studv.a significant reduction in BKCa channe expression n the amygdala of mice accompanied anxiety-like behavior induced by acute stress,Whole-cell patch-clamp recordings from LA neurons of the anxious animals revealed a pronounced reduction in the fast after hyperpolarization(fAHP)of action potentials mediated by BKCa channels

关键词： cell=neuron Method=electrophysiology Topic=stress

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Endophilin Al regulates spine morphogenesis and synaptic plasticity

Endophilin Al regulates spine morphogenesis and synaptic pla...

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第九届全国钙信号和细胞功能研讨会

作者： Yanrui Yang and Jia-Jia Liu State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China

＜正＞Morphological plasticity of dendritic spines and synapses is crucial for their physiological *** we show that endophilin A1,a protein involved in synaptic recycling,also localizes to dendritic spines of CNS *** of endophilin A1 causes a decrease in the number of spines and an increase in the number of filopodia,leading to significantly impaired synapse formation as indicated by a decrease in the number of synaptophysin puncta localized on dendrites and synaptic plasticity upon chemical *** addition,endophilin A1 interacts with

关键词： cell=neuron Method=cell biology Topic=spine morphology

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Regulation of voltage-gated Ca2+ channels by RGK proteins

Regulation of voltage-gated Ca2+ channels by RGK proteins

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第九届全国钙信号和细胞功能研讨会

作者： Zafir Buraei Wei K.Zhang Department of Biological Sciences Columbia University New YorkNY 10027U.S.A.

The Rem,Rem2,Rad and Gem/Kir(RGK)family of monomeric GTP-binding proteins potently inhibits high-voltage activated(HVA)Ca channels The molecular mechanisms of this inhibition are largely *** proteins associate directly with Ca charmelβsubunits(Caβ)and this interaction is widely thought to be essential for RGKs’inhibitory action We find that Gem suppresses the activity of surface P/Q-type Ca channels in Xenopus oocytes and that this inhibition requires Caβbut not the Gem/Caβ*** constructing chimeras between P/Q channels and RGK-insensitive low-voltage activated T-type channels,we identify a region of Caα

关键词： cell=neuron Method=electrophysiology Topic=modulation

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Mechanism of Ca2+ dependent activation of BK channels

Mechanism of Ca2+ dependent activation of BK channels

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第九届全国钙信号和细胞功能研讨会

作者： Jianmin Cui Department of Biomedical Engineering,Washington University,St.Louis,MO 63130,USA

The BK type Ca-activated Kchannels are involved in the regulation of neurotransmitter release and muscle contraction,Structurally,BK channels are homologous to voltage-and ligand-gated K channels,having a voltage sensor and pore as the membranespanning domain and a cytosolic domain containing metal binding sites. Recently published electron cryomicroscopy(cryo-EM)and X-ray crystallographic structures of the BK channel provided the first glimpse into the assembly of these

关键词： cell=neuron Method=electrophysiology Topic=ion channel

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Structural basis of activation and preinactivation of BK(hβ2) channels

Structural basis of activation and preinactivation of BK(hβ...

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第九届全国钙信号和细胞功能研讨会

作者： Pan-Pan Hou,Wen-Ping Zeng,Ge-Liang Gan,Cai-Xia Lv,Xi-Ying Guo,Zheng Zhang, Hao-Wen Liu,Ying Wu,Jing Yao,Sheng Wang and Jiu-Ping Ding Key laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology,Huazhong University of Science and Technology, Wuhan,Hubei,430074,China

Large-conductance calcium-and voltage-activated potassium(BK)channels regulate the electric activities and neurotransmitter releases in excitable cells in response to both the membrane potential and cytosolic *** auxiliary hβ2 subunits not only enhance the BK gating,but also inactivate the BK ***,some strong evidences revealed that a second short-1ived conducting state,termed as a preinactivation state (O*),existed between the open(O)and inactivated(I)states in the BK(hβ2)*** interacting mechanism of BK mSlo1αand hβ2 has been studied for over 10 years,but

关键词： cell=neuron Method=electrophysiology Topic=ion channel

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能量代谢调节激素对离子通道和突触可塑性的作用及其机制

能量代谢调节激素对离子通道和突触可塑性的作用及其机制

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第九届全国钙信号和细胞功能研讨会

作者：陈建国华中科技大学同济医学院基础医学院药理学系

＜正＞下丘脑是神经-内分泌两大机能系统的结合点,在维持机体生命活动和内环境恒定中起重要的作用。许多能量代谢调节激素如瘦素（Leptin）、胰岛素（Insulin）和开胃素（Orexin）等对离子通道的调节,影响影响突触传递,递质释放和信号... 详细信息

＜正＞下丘脑是神经-内分泌两大机能系统的结合点,在维持机体生命活动和内环境恒定中起重要的作用。许多能量代谢调节激素如瘦素（Leptin）、胰岛素（Insulin）和开胃素（Orexin）等对离子通道的调节,影响影响突触传递,递质释放和信号转导过程,介导"能量代谢一神经内分泌"的联动调控过程,也参与调节其他的中枢神经系统功能。本实验室研究发现,orexin-A增加下丘脑NPY神经元L-型钙电流,进而钙依赖性地激活下丘脑AMPK,影响食欲行为。L-型钙通道阻断剂也能抑制orexin-A诱导的AMPK激活、摄食增加。leptin通过不同的受体后信号级联通路差异性地调节下丘脑NPY神经元和POMC神经元钙电流。进一步实验发现,leptin

关键词： cell=neuron Method=electrophysiology Topic=disease

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