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Novel loci and potential mechanisms of major depressive disorder,bipolar disorder,and schizophrenia

Science China(Life Sciences) 2022年第1期65卷 167-183页

作者： He Wang Zhenghui Yi Tieliu Shi Center for Bioinformatics and Computational Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal UniversityShanghai 200062China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang University&Capital Medical UniversityBeijing 100083China

Different psychiatric disorders share genetic relationships and pleiotropic loci to certain *** integrated and analyzed datasets related to major depressive disorder(MDD),bipolar disorder(BIP),and schizophrenia(SCZ)from the Psychiatric Genomics Consortium using multitrait analysis of genome-wide association analysis(MTAG).MTAG significantly increased the effective sample size from 99,773 to 119,754 for MDD,from 909,061 to 1,450,972 for BIP,and from 856,677 to 940,613 for *** discovered 7,32,and 43 novel lead single nucleotide polymorphisms(SNPs)and 1,6,and 3 novel causal SNPs for MDD,BIP,and SCZ,respectively,after *** identified rs8039305 in the FURIN gene as a novel pleiotropic locus across the three *** performed marker analysis of genomic annotation(MAGMA)and Hi-C-coupled MAGMA(H-MAGMA)based gene-set analysis and identified 101 genes associated with the three disorders,which were enriched in the regulation of postsynaptic membranes,postsynaptic membrane dopaminergic synapses,and Notch signaling ***,we performed Mendelian randomization analysis using different tools and detected a causal effect of BIP on ***,we demonstrated the usage of combined genome-wide association studies summary statistics for exploring potential novel mechanisms of the three psychiatric disorders,providing an alternative approach to integrate publicly available summary data.

关键词： psychiatric disorders multitrait analysis of genome-wide association analysis novel loci Mendelian randomization causal effects

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Exploring the differential impacts of urban transit system on the spatial distribution of local and floating population in Beijing

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Journal of Geographical Sciences 2017年第6期27卷 731-751页

作者： ZHAO Meifeng LIU Shenghe QI Wei College of Urban and Environmental Science Tianjin Normal University Tianjin 300387 China Institute of Geographic Sciences and Nature Resources Research CAS Beijing 100101 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 1000 China

The floating population has become the main driver of urban population excessive growth in China＇s mega cities. Urban transit system （UTS） is a significant factor in population spatial distributions within urban areas, especially rapid and high-capacity transit systems. This paper analyzes the causal effects of the extension of expressways and subways between 2000 and 2010 in the Beijing Metropolitan Area （BMA）, focusing on the group differences between the local residents and the floating population. Due to the endogeneity of transportation improvements and population growth, Instrumental Variable （IV） regression model is applied to avoid this problem. The results show the local residents increased in the inner suburbs but decreased in the city center, while the floating population increased in the majority areas. IV regression results show that the extension of urban transit systems had statistically significant impacts on population growth across the BMA, The results also show that the extension of urban subway system had more effects on the floating population than the local residents across the BMA. It is mainly caused by the rather low fare of urban subway system. This implies that the excessive subsidy on urban subway system could result in ex- cessive floating population growth and residential differentiation, even residential segregation Hence, it is necessary to plan and design reasonable and scientific urban transit systems in order to advance reasonable population size and promote residential integration. Moreover, the regional analysis shows that the effects of urban transportation improvements on the local residents are not statistically significant in the inner suburbs. It implies that urban transportation improvements had limited effects on inducing people to move to suburban areas and controlling center city＇s population in Beijing. Therefore, it should be stressed the differenti- ated effects of urban transportation improvements on population distr

关键词： urban transit systems (UTS) population spatial distribution causal effects group differences Beijing

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Quantifying the impacts of human mobility restriction on the spread of coronavirus disease 2019:an empirical analysis from 344 cities of China

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Chinese Medical Journal 2021年第20期134卷 2438-2446页

作者： Jing Tan Shao-Yang Zhao Yi-Quan Xiong Chun-Rong Liu Shi-Yao Huang Xin Lu Lehana Thabane Feng Xie Xin Sun Wei-Min Li Chinese Evidence-Based Medicine Center National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonOntario L8S 4L8Canada Biostatistics Unit St Joseph’s Healthcare-HamiltonOntario L8S 4L8Canada School of Economics Sichuan UniversityChengduSichuan 610041China College of Systems Engineering National University of Defense TechnologyChangshaHunan 410073China Department of Global Public Health Karolinska InstituteStockholmSweden Center for Health Economics and Policy Analysis Department of Health Research MethodsEvidenceand ImpactMcMaster UniversityHamiltonOntario L8S 4L8Canada Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China

Background:Since the outbreak of coronavirus disease 2019(COVID-19),human mobility restriction measures have raised controversies,partly because of the inconsistent *** empirical study is promptly needed to reliably assess the causal effects of the mobility *** purpose of this study was to quantify the causal effects of human mobility restriction on the spread of ***:Our study applied the difference-in-difference(DID)model to assess the declines of population mobility at the city level,and used the log-log regression model to examine the effects of population mobility declines on the disease spread measured by cumulative or new cases of COVID-19 over time after adjusting for ***:The DID model showed that a continual expansion of the relative declines over time in *** 4 weeks,population mobility declined by-54.81%(interquartile range,-65.50%to-43.56%).The accrued population mobility declines were associated with the significant reduction of cumulative COVID-19 cases throughout 6 weeks(ie,1%decline of population mobility was associated with 0.72%[95%CI:0.50%-0.93%]reduction of cumulative cases for 1 week,1.42%2 weeks,1.69%3 weeks,1.72%4 weeks,1.64%5 weeks,and 1.52%6 weeks).The impact on the weekly new cases seemed greater in the first 4 weeks but faded *** effects on cumulative cases differed by cities of different population sizes,with greater effects seen in larger ***:Persistent population mobility restrictions are well *** of mobility restrictions in major cities with large population sizes may be even more important.

关键词： Coronavirus disease 2019 Mobility restriction Disease spread causal effects

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