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World Journal of Clinical Cases 2022年第15期10卷 5082-5087页

作者： Su-Fei Pan Yuan-Yuan Zhang Xiao-Zhen Wang Jing-Jing Sun Shao-Ling Song Yu-Rong Tang Ji-Liang Wang Department of Laboratory Medicine Shengli Oilfield Central HospitalDongying 257034Shandong ProvinceChina

BACKGROUND Mycobacterium abscessus(***)is a rapidly growing mycobacterium and ubiquitous in the environment,which infrequently causes disease in ***,it can cause cutaneous or respiratory infections among immunocompromised *** to the resistance to most antibiotics,the pathogen is formidable and *** SUMMARY Here,we present a case of catheter-related *** infections in a patient with motor neurone *** and peripheral blood cultures of the patient showed positive results during Gram staining and acid-fast *** alarm time of catheter blood culture was 10.6 h earlier than that of peripheral *** removal of the peripherally inserted central catheter,secretion and catheter blood culture were *** was identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry and 16S rDNA *** For catheter-related *** infection,rapid diagnosis and timely and adequate antimicrobial therapy are crucial.

关键词： catheter-related infections Diagnosis Motor neurone disease Mycobacterium abscessus Case report

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Care Measures and Health Outcomes in a Pediatric Intensive Care Unit in Brazil

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Open Journal of Pediatrics 2023年第5期13卷 697-706页

作者： Arnildo Linck Junior Flávia Lopes Gabani Edmarlon Girotto Ana Maria Rigo Silva Selma Maffei Andrade Department of Pediatrics and Pediatric Surgery Universidade Estadual de Londrina Londrina Brazil

Introduction: In low- and middle-income countries, including Brazil, conditions that favor mortality in the PICU remain significant. Compared to developed countries, there is a shortage of skilled human resources, lower availability of technological resources, greater difficulty of access and a higher incidence of infections, including both those acquired prior to admission and those resulting from treatment and hospitalization (i.e., healthcare-associated infections (HAIs)). HAIs in the PICU include ventilator-associated pneumonia and catheter-related bloodstream infections. Actions for the prevention of HAIs can minimize the occurrence of negative outcomes. Materials and Methods: This is an epidemiological study comparing admissions at the PICU of a high-complexity hospital in South Brazil over two three-year periods: 2012-2014 (before the measures were adopted) and 2015-2017 (after the measures). The care measures were adopted mainly at the beginning of 2015 and consisted of expansion of physical therapy care, adoption of care protocols, acquisition of new materials and equipment (transparent dressings for central catheters, high-tech mechanical ventilators and multiparametric monitors) and multidisciplinary team training. The frequency of the outcomes mortality, length of PICU stay, diagnosis of catheter-related bloodstream infection, need for and duration of ventilatory support and diagnosis of ventilator-associated pneumonia were compared between the two trienniums using logistic regression with adjustment for age in months and need of vasoactive drugs. Results: A total of 1140 admissions were analyzed (470 in the first triennium and 670 in the second), representing an increase in the admission rate of 42.6% after the adoption of the measures. After adjustments, significant reductions in the frequency of mortality (adjusted OR [adjOR] = 0.54;CI 95%: 0.34 - 0.84), length of PICU stay > 7 days (adjOR = 0.75;CI 95%: 0.57 - 0.97) and duration of ventilatory suppor

关键词： Pediatric Intensive Care Units Outcomes Assessment In-Hospital Mortality Hospital Stay Mechanical Ventilation catheter-related infections

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