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Interaction between catechol-o-methyltransferase val/met polymorphism and cognitive reserve for negative symptoms in schizophrenia

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World Journal of Psychiatry 2024年第5期14卷 695-703页

作者： Wen-Peng Hou Xiang-Qin Qin Wei-Wei Hou Yun-Yi Han Qi-Jing Bo Fang Dong Fu-Chun Zhou Xian-Bin Li Chuan-Yue Wang Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China

BACKGRoUND Cognitive reserve(CR)and the catechol-o-methyltransferase(CoMT)val/met polymorphism are reportedly linked to negative symptoms in ***,the regulatory effect of the CoMT genotype on the relationship between CR and negative symptoms is still *** To investigate whether the relationship between CR and negative symptoms could be regulated by the CoMT val/met *** In a cross-sectional study,54 clinically stable patients with schizophrenia underwent assessments for the CoMT genotype,CR,and negative *** was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence *** CoMT met-carriers exhibited fewer negative symptoms than val *** the total sample,significant negative correlations were found between negative symptoms and information,*** between information,similarities and negative symptoms were observed in val homozygotes only,with information and similarities showing interaction effects with the CoMT genotype in relation to negative symptoms(information,β=-0.282,95%CI:-0.552 to-0.011,P=0.042;similarities,β=-0.250,95%CI:-0.495 to-0.004,P=0.046).CoNCLUSIoN This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the CoMT genotype in schizophrenia.

关键词： catechol-o-methyltransferase val/met polymorphism Cognitive reserve Crystallized intelligence Negative symptoms Schizophrenia

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