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‘‘Amano'' lipase DF-catalyzed efficient synthesis of 2,20-arylmethylene dicyclohexane-1,3-dione derivatives in anhydrous media

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Chinese Chemical Letters 2014年第8期25卷 1190-1192页

作者： Ling Jiang Bo Wang Rong-Rong Li Sa Shen Hong-Wei Yu Li-Dan Ye Department of Chemical and Biological Engineering Zhejiang University College of Materials and Chemical Engineering Hainan University School of Chemical and Material Engineering Jiangnan University

A simple and efficient method was developed for the synthesis of 2.2＇-arylmethylene dicyclohexane-1,3- dione derivatives via the Knoevenagel-Michael cascade reactions of aromatic aldehydes and 1,3-cyclic diketones catalyzed by ＂Amano＂ lipase DF, which expands the application field of enzyme catalytic promiscuity. This protocol provides several advantages over the traditional chemical synthesis, such as simple work-up procedure, high yields Cup to 94%） and environmental friendliness.

关键词：＂Amano＂ lipase DF Knoevenagel condensation Michael addition catalytic promiscuity

Enzymatic promiscuity： Escherichia coli BioH Esterase-catalysed Aldol Reaction and Knoevenagel Reaction

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Chemical Research in Chinese Universities 2014年第2期30卷 289-292页

作者： JIANG Ling YU Hongwei Department of Chemical and Biological Engineering Zhejiang University Hangzhou 310007 P.R.China

Esterase BioH,which is obligatory for biotin synthesis in Escherichia coli,was found to exhibit a promiscuous ability to catalyse Aldol and Knoevenagel reactions with moderate to good yields.The reaction conditions including organic solvent,molar ratio of ketone to aldehyde,enzyme amount,and reaction time were investigated to evaluate the effect of different reaction conditions on yield.Target compounds were afforded in the best yield of 91.2％ for Aldol reaction and 54.7％ for Knoevenagel reaction.In addition,because the enzyme could be prepared with a low cost,this protocol could provide an economic route to conduct Aldol and Knoevenagel reactions,which expand the field of enzymatic promiscuity.

关键词： Escherichia coli BioH esterase catalytic promiscuity Aldol reaction Knoevenagel reaction

Enzymatic promiscuity：＂Amano＂ Lipase AS-catalysed Synthesis of Naphthopyran Derivatives in Anhydrous Media

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Chemical Research in Chinese Universities 2014年第3期30卷 396-399页

作者： JIANG Ling YU Hongwei Department of Chemical and Biological Engineering Zhejiang University Hangzhou 310007 P. R. China

＂Amano＂ lipase AS（lipase from Aspergillus niger）, which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to... 详细信息

关键词：＂Amano＂ lipase AS catalytic promiscuity Multi-component reaction Naphthopyran derivative

Advances in photo-enzymatic-coupling catalysis system

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Systems Microbiology and Biomanufacturing 2021年第3期1卷 245-256页

作者： Yunxiu Bai Licheng Wang Jun Ge Key Lab for Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Photosynthesis,as an efficient pathway for solar energy capture and utilization,has supported aerobionts for billions of years.The imitation of photosynthesis to construct artificial photo-enzymatic-coupling catalysis system has become a pow-erful means to solve energy and environmental problems.After years of in-depth research on this coupled system,through ingenious and rational design,the synergistic effect of photo-and enzymatic catalyses has played a significant role in many different fields,including solar-driven fuel production,chiral chemical synthesis and carbon dioxide fixation.Furthermore,light in enzymatic catalysis could also endow enzyme new possibilities.Photo-induced radical cofactor could bring catalytic promiscuity to enzymes,making them catalyze reactions that natural enzymes cannot.This review summarizes the advances in photo-enzymatic-coupling catalysis system and introduces its essential components,their integration and application.The possibilities presented by photo-induced catalytic promiscuity and its significance for expanding the toolbox of enzymes are also discussed.

关键词： Photo-enzymatic-coupled catalysis Artificial photosynthesis catalytic promiscuity