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Selenocystine Induces caspase-independent apoptosis in MCF-7 Breast Carcinoma Cells with Involvement of p53 Phosphorylation and Mitochondrial Dysfunction

Selenocystine Induces Caspase-Independent Apoptosis in MCF-7...

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第五届全国化学生物学学术会议

作者： Tianfeng Chen Yum-Shing Wong~* Biology Department,the Chinese University of Hong Kong,Hong Kong SAR,China

＜正＞Chemoprevention refers to the use of agents to inhibit,reverse or retard *** chemoprevention has received increasing attention in recent *** agents,including naturally occurring and synthetic compounds,have been demonstrated to exhibit cancer preventive activity （Surh,2003）.Se is a dietary essential trace element with important biological functions(Rayman,

关键词： Selenium caspase-independent apoptosis p53 ROS

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Induction of apoptosis in the Immature Mouse Testes by a Mixture of Melamine and Cyanuric Acid

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Journal of Integrative Agriculture 2012年第12期11卷 2058-2066页

作者： YOU Hua ZHU Jin-feng SHE Rui-ping CHANG Ling-ling SHI Rui-han DING Ye CHI Li-juan LIU Bin YUE Zhuo TIAN Ji-jing MAO Jing-jing SU Li-fang Key Laboratory of Zoonosis Ministry of Agriculture/Department of Veterinary Pathology College of Veterinary Medicine China Agricultural University China Animal Disease Control Center National Animal Husbandry Service

The toxicity of melamine has attracted much attention since the recent outbreaks of renal injury in pets and infants. Previous studies indicated that melamine by itself had low toxicity, whereas a mixture of melamine and cyanuric acid （M＋CA） could cause serious renal damage. At present, most researches on the toxicity of M＋CA are focused on the kidney. However, little is known about the adverse effects of this mixture on the reproductive system. In the present study, the toxicity of M＋CA to testes was investigated. Immature male mice were orally dosed with 0, 0.6, 3, and 15 mg kg-1 d-1 of a 1：1 M＋CA for 28 d. Pathological changes occurred in germ cells, such as loose arrangement, reduced numbers and karyopyknosis, indicating that this mixture was toxic to spermatogenesis. Compared with the control group, the TUNEL- positive germ cells increased significantly and the ratio of Bcl-2 to Bax, total antioxidant capacity and superoxide dismutase activity decreased significantly in the 3 and 15 mg kg-1 d- M＋CA treated group, while the activities of caspase-3, caspase- 8 and caspase-9 remained unchanged. The results suggest that M＋CA can induce apoptosis in the mice testes. The downregulation of Bcl-2/Bax and oxidative stress may play a pivotal role in the induction of apoptosis by M＋CA in mice testes.

关键词： melamine/cyanuric acid mixture testes injury caspase-independent apoptosis

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维普期刊数据库

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AIFM1 variants associated with auditory neuropathy spectrum disorder cause apoptosis due to impaired apoptosis-inducing factor dimerization

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第2期24卷 172-184页

作者： YUE QIU HONGYANG WANG HUAYE PAN JING GUAN LEI YAN MINGJIE FAN HUI ZHOU XUANHAO ZHOU KAIWEN WU ZEXIAO JIA QIANQIAN ZHUANG ZHAOYING LEI MENGYAO LI XUE DING AIFU LIN YONG FU DONG ZHANG QIUJU WANG QINGFENG YAN College of Life Sciences Zhejiang UniversityHangzhou 310058China Senior Department of Otolaryngology Head and Neck SurgeryChinese PLA Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Department of Pediatrics the First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003China The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310052China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China

Auditory neuropathy spectrum disorder(ANSD)represents a variety of sensorineural deafness conditions characterized by abnormal inner hair cells and/or auditory nerve function,but with the preservation of outer hair cell *** represents up to 15%of individuals with hearing *** mutation screening,bioinformatic analysis and expression studies,we have previously identified several apoptosis-inducing factor(AIF)mitochondria-associated 1(AIFM1)variants in ANSD families and in some other sporadic ***,to elucidate the pathogenic mechanisms underlying each AIFM1 variant,we generated AIF-null cells using the clustered regularly interspersed short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system and constructed AIF-wild type(WT)and AIF-mutant(mut)(p.T260A,p.R422W,and p.R451Q)stable transfection cell *** then analyzed AIF structure,coenzyme-binding affinity,apoptosis,and other *** revealed that these variants resulted in impaired dimerization,compromising AIF *** reduction reaction of AIF variants had proceeded slower than that of *** average levels of AIF dimerization in AIF variant cells were only 34.5%-49.7%of that of AIF-WT cells,resulting in caspase-independent *** average percentage of apoptotic cells in the variants was 12.3%-17.9%,which was significantly higher than that(6.9%-7.4%)in ***,nicotinamide adenine dinucleotide(NADH)treatment promoted the reduction of apoptosis by rescuing AIF dimerization in AIF variant *** findings show that the impairment of AIF dimerization by AIFM1 variants causes apoptosis contributing to ANSD,and introduce NADH as a potential drug for ANSD *** results help elucidate the mechanisms of ANSD and may lead to the provision of novel therapies.

关键词： Auditory neuropathy spectrum disorder apoptosis-inducing factor(AIF)mitochondria-associated 1(AIFM1)variants Dimerization caspase-independent apoptosis Nicotinamide adenine dinucleotide(NADH)treatment

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mTOR and MAPK signal pathway involved in cryptotanshinone inhibiting cancer cell growth

mTOR and MAPK signal pathway involved in cryptotanshinone in...

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全国中药药理学会联合会学术交流大会

作者： Wenxing Chen,Yin Lu College of Pharmacy,Nanjing University of Chinese Medicine

Cryptotanshinone(CPT),a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer ***,little is known about its anticancer ***, we show that CPT inhibited cancer cell proliferation by arresting cells in G1-GO phase of the cell *** is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein ***,we found that CPT inhibited the signaling pathway

关键词： Cryptotanshinone Cell cycle Cyclin D1 Retinoblastoma protein mTOR Reactive oxygen species MAPKs p38 JNK ERK1/2 caspase-independent apoptosis

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