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Analysis of the causes of primary revision after unicompartmental knee arthroplasty: A case series

World Journal of Clinical cases 2024年第9期12卷 1560-1568页

作者： Jin-Long Zhao Xiao Jin He-Tao Huang Wei-Yi Yang Jia-Hui Li Ming-Hui Luo Jun Liu Jian-Ke Pan The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Chinese Medicine The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina The Second School of Clinical Medical Sciences Guangzhou University of Chinese MedicineGuangdong Academy of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Affiliated Hospital Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120Guangdong ProvinceChina The Affiliated TCM Hospital Guangzhou Medical UniversityGuangzhou 510405Guangdong ProvinceChina The Research Team on Bone and Joint Degeneration and Injury Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Unicompartmental knee arthroplasty(UKA)has great advantages in the treatment of unicompartmental knee osteoarthritis,but its revision rate is higher than that of total knee arthroplasty.AIM To summarize and analyse the causes of revision after UKA.METHODS This is a retrospective case series study in which the reasons for the first revision after UKA are summarized.We analysed the clinical symptoms,medical histories,laboratory test results,imaging examination results and treatment processes of the patients who underwent revision and summarized the reasons for primary revision after UKA.RESULTS A total of 13 patients,including 3 males and 10 females,underwent revision surgery after UKA.The average age of the included patients was 67.62 years.The prosthesis was used for 3 d to 72 months.The main reasons for revision after UKA were improper suturing of the surgical opening(1 patient),osteophytes(2 patients),intra-articular loose bodies(2 patients),tibial prosthesis loosening(2 patients),rheumatoid arthritis(1 patient),gasket dislocation(3 patients),anterior cruciate ligament injury(1 patient),and medial collateral ligament injury with residual bone cement(1 patient).CONCLUSION The causes of primary revision after UKA were gasket dislocation,osteophytes,intra-articular loose bodies and tibial prosthesis loosening.Avoidance of these factors may greatly reduce the rate of revision after UKA,improve patient satisfaction and reduce medical burden.

关键词： Unicompartmental knee arthroplasty Total knee arthroplasty Causes Revision case series

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Comparison of Oral Manifestations in Hospitalized COVID-19 Positive Patients and COVID-19 Negative Dental Outpatients. A case series Study and Literature Review

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第3期13卷 225-250页

作者： Flora Zervou-Valvi Emmanouil M. Valvis Angeliki Giannopoulou Eleana Stoufi Charilaos Samaras Olga Spiropoulou Antonia Hadjicosta Smaragda Diamanti Asklepieion Voulas’ General Hospital Athens Greece School of Dentistry European University of Cyprus Nicosia Cyprus

Background: The Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease, also named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which can cause various systemic manifestations that pose a threat to human life. Oral lesions in patients with COVID-19 may appear during or after the illness and may or may not be a consequence of the viral infection. Objective: In this case series we compare the oral manifestations in hospitalized COVID-19 positive patients and COVID-19 negative dental outpatients. Methods: 60 hospitalized COVID-19 patients and 41 control patients, were examined for oral signs and symptoms. The controls were dental patients who visited the hospital for dental care without complaining of any problems related to the oral cavity itself. Results: We have observed a strong association between certain clinical findings and COVID-19, including alterations in taste (ageusia, dysgeusia, and hypogeusia), anosmia, hairy tongue, tongue imprints, red tongue, erythematous candidiasis, pseudomembranous candidiasis, and exfoliative cheilitis. A trend but not statistically significant association at the level of 5% was also noted for colored tongue, linea alba, and pale mucosa. On the contrary, fissured tongue and oral mucosa pigmentation were more frequent in the controls, statistically significant at the level of 5%. Conclusion: COVID-19 has been found to impact the oral cavity, resulting in various oral lesions that can be attributed to either the direct action of the virus or the patient’s immune response.

关键词： case series COVID-19 SARS-CoV-2 Oral Lesions/Manifestations Hospitalized Patients Control/Dental Patients

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case series in Indonesia:B.1.617.2(delta)variant of SARS-CoV-2 infection after a second dose of vaccine

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World Journal of Clinical cases 2022年第36期10卷 13216-13226页

作者： Anis Karuniawati Ari F Syam Armand Achmadsyah Fera Ibrahim Yulia Rosa Pratiwi Sudarmono Fadilah Fadilah Menaldi Rasmin Department of Clinical Microbiology Faculty of MedicineUniversitas Indonesia/Cipto Mangunkusumo Jakarta IndonesiaJakarta 10430DKI JayaIndonesia Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversitas Indonesia/Cipto Mangunkusumo Jakarta IndonesiaJakarta PUsat 10430DKI JayaIndonesia Faculty of Medicine Universits IndonesiaJakarta Pusat 10430DKI JayaIndonesia Department of Medical Chemistry Faculty of MedicineUniversitas IndonesiaJakarta IndonesiaFaculty of MedicineUniversitas IndonesiaJakarta 10430DKI JayaIndonesia Department of Pulmonology and Respiratory Medicine Faculty of MedicineUniversitas Indonesia/Persahabatan HospitalJakarta IndonesiaJakarta Pusat 10430DKI JayaIndonesia

BACKGROUND The B.1.617.2(delta)variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first discovered in Maharashtra in late 2020 and has rapidly expanded across India and worldwide.It took only 2 mo for this variant to spread in Indonesia,making the country the new epicenter of the delta variant as of July 2021.Despite efforts made by accelerating massive rollouts of current vaccines to protect against infection,cases of fully-vaccinated people infected with the delta variant have been reported.AIM To describe the demographic statistics and clinical presentation of the delta variant infection after the second dose of vaccine in Indonesia.METHODS A retrospective,single-centre case series of the general consecutive population that worked or studied at Faculty of Medicine,Universitas Indonesia with confirmed Delta Variant Infection after a second dose of vaccine from 24 June and 25 June 2021.cases were collected retrospectively based on a combination of author recall,reverse transcription-polymerase chain reaction(RT-PCR),and whole genome sequencing results from the Clinical Microbiology Laboratory,Faculty of Medicine,Universitas Indonesia.RESULTS Between 24 June and 25 June 2021,15 subjects were confirmed with the B.1.617.2(delta)variant infection after a second dose of the vaccine.Fourteen subjects were vaccinated with CoronaVac(Sinovac)and one subject with ChAdOx1 nCoV-19(Oxford-AstraZeneca).All of the subjects remained in home isolation,with fever being the most common symptom at the onset of illness(n=10,66.67%).The mean duration of symptoms was 7.73 d(±5.444).The mean time that elapsed from the first positive swab to a negative RT-PCR test for SARS-CoV-2 was 17.93 d(±6.3464).The median time that elapsed from the second dose of vaccine to the first positive swab was 87 d(interquartile range:86-128).CONCLUSION Although this case shows that after two doses of vaccine,subjects are still susceptible to the delta variant infection,currently available vaccines remain the most effective protection

关键词： COVID-19/SARS-CoV-2 infection B.1.617.2(delta)variant Fully vaccinated case series

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Fabry Disease with Aseptic Meningitis:A case series and Literature Review of an Underestimated Clinical Presentation

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Current Medical Science 2022年第2期42卷 274-279页

作者： Ming-yu TANG Yue-hui HONG Li-xin ZHOU Jun NI Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100005China

Objective Fabry disease(FD)is an X-linked lysosomal storage disease caused by the mutation in theα-galactosidase A gene that leads to a consequently decreasedα-galactosidase A enzyme activity and a series of clinical presentations.However,FD accompanied with aseptic meningitis can be relatively scarce and rarely reported,which leads to significant clinical misdiagnosis of this disease.Methods Sixteen patients diagnosed with FD based on a decreased activity ofα-galactosidase A enzyme and/or genetic screening were identified through a 6-year retrospective chart review of a tertiary hospital.Clinical presentations,brain magnetic resonance imaging,cerebrospinal fluid analysis,treatment and outcome data were analyzed in cases of aseptic meningitis associated with FD.Results Three out of 16 cases exhibited aseptic meningitis associated with FD.There was one female and two male patients with a mean age of 33.3 years.A family history of renal failure or hypertrophic cardiomyopathy was found in 3 cases.All cases presented with a persistent or intermittent headache and recurrent ischemic stroke.The cerebrospinal fluid analyses showed mild pleocytosis in 2 patients and an elevated level of protein in all patients.Cerebrospinal fluid cytology revealed activated lymphocytes,suggesting the existence of aseptic meningitis.In the literature review,up to 9 cases presenting with FD and aseptic meningitis were found,which bore a resemblance to our patients in demographic and clinical characteristics.Conclusion Our cases suggested that aseptic meningitis in FD might be under-detected and easily misdiagnosed,and should be more thoroughly examined in further cases.

关键词： Fabry disease aseptic meningitis ischemic stroke headache case series

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Retroperitoneal and abdominal bleeding in anticoagulated COVID-19 hospitalized patients:case series and brief literature review

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World Journal of Clinical cases 2023年第7期11卷 1528-1548页

作者： Delian Evrev Metodija Sekulovski Milena Gulinac Hristo Dobrev Tsvetelina Velikova George Hadjidekov Department of Cardiac Surgery University Hospital LozenetzSofia 1407Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Anesthesiology and Intensive Care University Hospital LozenetzSofia 1407Bulgaria Department of General and Clinical Pathology Medical University of PlovdivPlovdiv 6000Bulgaria Department of Radiology University Hospital“Lozenetz”Kozyak 1 str.Sofia 1407Bulgaria

BACKGROUND Hospitalized and severely ill coronavirus disease 2019(COVID-19)patients necessitate prophylactic or therapeutic anticoagulation to minimize the risk of thrombosis at different sites.Life-threatening bleeding complications include spontaneous iliopsoas hematoma,peritoneal bleeding,and extra-abdominal manifestations such as intracranial hemorrhage.case SUMMARY Bleeding in the abdominal wall results in less severe complications than seen with iliopsoas hematoma or peritoneal bleeding.In our case series of 9 patients,we present retroperitoneal and abdominal bleeding complications following anticoagulation in hospitalized COVID-19 patients with severe acute respiratory syndrome coronavirus 2 pneumonia.Contrast-enhanced computed tomography(CE-CT)is the best imaging modality for assessing hematoma secondary to anticoagulation and determines the therapeutic approach,whether interventional,surgical,or conservative management.CONCLUSION We present the role of CE-CT for rapid and precise localization of the bleeding site and prognostic counseling.Finally,we provide a brief review of the literature.

关键词： COVID-19 Retroperitoneal bleeding Abdominal bleeding Anticoagulation drugs COVID-19 hospitalized patients case report case series

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Long-term experience with debulking surgery in extensive hepatic alveolar echinococcosis:A case series and literature review

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Asian Pacific Journal of Tropical Medicine 2022年第10期15卷 468-473页

作者： Mohsen Aliakbarian Marcello Di Martino Sara Saeidi Department of General Surgery Surgical Oncology Research CenterMashhad University of Medical SciencesMashhadIran Division of Hepatobiliary and Liver Transplantation Surgery.A.O.R.N.Cardarelli NapoliItaly

Objective:To assess the role of debulking surgery in extensive hepatic alveolar echinococcosis(HAE).Methods:Five cases of extensive HAE undergoing debulking surgery with their long-term follow-ups were reported.Additionally,a systematic review was carried out.Results:The average age of patients in the study was(50.8±17.1)years(range 36 to 77 years).Three cases were female.The median follow-up period was 61 months(range 12 to 84 months).Left liver resections were performed in 2 cases and right hemihepatectomies were undertaken in 2 cases.Two patients(cases 2 and 4)developed early surgical complications,while one of them(case 4)who suffered from the recurrent sub-hepatic abscess died at 12 months postoperatively.Conclusions:This study highlights the importance of debulking surgery for the management of complex symptomatic HAE lesions in patients with no curative option available.

关键词： Alveolar echinococcosis Debulking surgery Reduction Palliative Echinoccocosis multilocularis case series

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Revisiting the upper eyelid blepharoplasty advancement flap:adaptation for the repair of full-thickness upper eyelid defects—a case series

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Annals of Eye Science 2022年第4期7卷 77-83页

作者： Yinon Shapira Katja Ullrich Raman Malhotra Andre S.Litwin Corneoplastic Unit Queen Victoria Hospital NHS TrustEast GrinsteadWest SussexUK

A blepharoplasty flap has been previously reported as a useful reconstruction approach for anterior lamellar defects lying between the lash line and the eyelid crease.We herein describe a variation of the blepharoplasty flap and suggest its use as an adjunct in the reconstruction of full-thickness lateral upper eyelid defects.Technique description and retrospective interventional case series.The reconstruction technique was used by an experienced oculoplastics surgeon(ASL)in 3 adults with malignant lesions involving the lateral upper eyelid margin,resulting in a post-excision 50%full-thickness defect between November 2017 and June 2020.The posterior lamella was reconstructed using an ipsilateral free tarsal graft and an inferiorly hinged transposition periosteal flap.The anterior lamella reconstruction was then performed using a local advancement flap utilizing the principles of upper blepharoplasty and Burow’s triangle.Almost full eyelid excursion and full gentle closure were evident at 1–2 weeks follow-up in all three cases.One case later developed 1–2 mm of gentle closure lagophthalmos and was managed successfully with topical lubricants.In all patients,the final eyelid contour and symmetry were adequate,with only minimal scarring,evident already 3 to 4 months postoperative.There were no major complications or need for revisions.The technique described herein highlights the utility of the blepharoplasty flap for lateral,full-thickness upper eyelid defects.This logical variation enables the reconstruction of significant defects using only local tissue,obeying the“like with like”principle,and helps avoid the need for a bridging flap.We provide preliminary evidence of the potential of a good cosmetic outcome of upper lid appearance and contour,together with a fast recovery of appropriate eyelid function.

关键词： Upper eyelid defect reconstruction blepharoplasty flap tarsal graft periosteal flap case series

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case series of COVID-19 patients from the Qinghai-Tibetan Plateau Area in China

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World Journal of Clinical cases 2021年第24期9卷 7032-7042页

作者： Ji-Jie Li Hui-Qiong Zhang Pei-Jun Li Zhi-Lan Xin Ai-Qi Xi Zhuo-Ma Yue-He Ding Zheng-Ping Yang Si-Qing Ma Department of Respiratory Medicine Qinghai Province Fourth People’s HospitalXining 810000Qinghai ProvinceChina Qinghai Provincial Center for Disease Control and Prevention Xining 810000Qinghai ProvinceChina Qinghai Province Fourth People's Hospital Xining 810000Qinghai ProvinceChina Department of Intensive Medicine The First People's Hospital of Qinghai ProvinceXining 810000Qinghai ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)is a serious infection caused by the new coronavirus severe acute respiratory syndrome coronavirus 2.The disease was first identified in December 2019 and has caused significant morbidity and mortality worldwide.AIM To explore the clinical characteristics and treatments for COVID-19 in the Qinghai-Tibetan Plateau Area in China.METHODS We retrospectively analyzed the blood cell counts(neutrophils and lymphocytes),blood gas analysis,and thoracic computed tomography changes of patients from Qinghai Province before,during,and after treatment(January 23,2020 to February 21,2020).In addition,we summarized and analyzed the information of critical patients.All data were analyzed using SPSS 17.0(SPSS Inc.,Chicago,IL,United States).The quantitative and count variables are represented as the mean±SD and n(%),respectively.RESULTS The main symptoms and signs of patients with COVID-19 were fever,dry cough,cough with phlegm,difficulty breathing,and respiratory distress with a respiration rate≥30 times/min,finger oxygen saturation≤93%in the resting state,and oxygenation index less than 200 but greater than 100(after altitude correction).Eighteen patients with COVID-19,of whom three were critical,and the others were in a mild condition,were included.The main manifestations included fever,dry cough,and fatigue.Three patients developed difficulty breathing and had a fever.They were eventually cured and discharged.Adjuvant examinations showed one case with reduced white cell count(6%)(<4×10^(9)/L),six with reduced count of lymphocytes(33%)(<0.8×10^(9)/L),and one with abnormal blood glucose level.All 18 patients were discharged,and no death occurred.CONCLUSION Our findings provide critical insight into assessing the clinical diagnosis and treatment for COVID-19 in the Tibetan plateau area.

关键词： Qinghai Plateau COVID-19 Blood cell Pneumonia case series

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Relative Bradycardia in Critically Ill Patients with Novel Coronavirus 19:A case series

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Cardiology Discovery 2023年第2期3卷 142-144页

作者： Qingpeng Li Liyun Luo Wenyi Tang Jian Chen Health Management Center Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdong 519000China Temporary Department of COVID-19 Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdong 519000China Department of Cardiovascular Medicine Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdong 519000China.

Severe coronavirus 2019 (COVID-19) infection is associated with myocardial injury and arrhythmia. Bradycardia is a newly recognized consequence of COVID-19. Relative bradycardia and its effects in 4 critically ill patients with COVID-19 was described in this case series. The 4 cases showed the same clinical phenomenon: sinus bradycardia without a compensatory increase in heart rate in response to elevation of body temperature. Typically, heart rate decreases as body temperature rises. The 4 patients were all men with an average age of 67 years. Patient 1 was a 78-year-old man with no major medical history who died from COVID-19 pneumonia. The other 3 patients recovered.

关键词： Bradycardia COVID-19 case series

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Using clinical cases to guide healthcare

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World Journal of Clinical cases 2024年第9期12卷 1555-1559页

作者： Michael Colwill Samantha Baillie Richard Pollok Andrew Poullis Department of Gastroenterology St George's University Hospital NHS Foundation TrustLondon SW170QTUnited Kingdom

Evidence-based practice(EBP)has been the gold standard in healthcare for nearly three centuries and aims to assist physicians in providing the safest and most effective healthcare for their patients.The well-established hierarchy of evidence lists systematic reviews and meta-analyses at the top however these methodologies are not always appropriate or possible and in these instances case-control studies,case series and case reports are utilised to support EBP.case-control studies allow simultaneous study of multiple risk factors and can be performed rapidly and relatively cheaply.A recent example was during the Coronavirus pandemic where case-control studies were used to assess the efficacy of personal protective equipment for healthcare workers.case series and case reports also play a role in EBP and are particularly useful to study rare diseases such as inflammatory bowel disease in transgender and gender non-conforming individuals.They are also vital in generating and disseminating early signals and encouraging further research.Whilst these methodologies have weaknesses,particularly with regards to bias and loss of patient confidentiality for rare pathologies,they have an important part to play in EBP and when appropriately utilised can significantly impact upon clinical practice.

关键词： Evidence based medicine Hierarchy of evidence case reports case series

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