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Rescue effects of aqueous seed extracts of Foeniculum vulgare and carum carvi against cadmium-induced hepatic, renal and gonadal damage in female albino rats

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1123-1133页

作者： Ahmed Abdel-Wahab Abdel-Razik Hashem Abdel-Razik Rabie Lotfy Abdel Aziz Physiology Department Faculty of Veterinary MedicineMinia University61519 El-MiniaEgypt Histology Department Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt Department of Theriogenology Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt

Objective: To investigate the protective effects of aqueous seed extracts of fennel"Foeniculum vulgare"(FVE) and caraway "carum carvi"(CCE) on liver, kidney and reproductive organs in female rats against cadmium chloride(CC) ***: A total of 36 adult female rats were divided into six groups, six in each *** group(fed normal diet), CC-treated group(50 mg CC/kg diet), CCE-treated group(150 mg CCE/kg diet), CCE + CC group, FVE(150 mg/kg diet) and FVE + CC. One month later, all rats were sacrificed and all samples were collected at proestrus ***: The toxic effects of CC were confirmed biochemically by significant increase of serum concentration of liver enzymes(P < 0.05), and creatinine(P < 0.001). Moreover,CC increased significantly the serum level of malondialdehyde(MDA) and decreased the total antioxidant capacity(TAC)(P < 0.001). In addition, serum concentrations of estrogen, progesterone, follicle-stimulating hormone(FSH) and luteinizing hormone(LH)were significantly decreased(P < 0.01). Histopathologically, CC-treated group revealed marked pathological changes in renal, hepatic, ovarian and uterine tissues. All toxic findings observed in liver and kidney with CC treatment were found to be ameliorated markedly after co-treatments with FVE or CCE. Furthermore, co-treatment of FVE with CC improved significantly all studied reproductive parameters(P < 0.01).Conclusions: Both FVE and CCE could be used as efficient treatments for liver and kidney against CC intoxication. Moreover, FVE could be utilized as a potent treatment to protect and improve female fertility from cadmium intoxication.

关键词： Cadmium carum carvi Foeniculum vulgare Liver Kidney Fertility

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Caraway as Important Medicinal Plants in Management of Diseases

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Natural Products and Bioprospecting 2019年第1期9卷 1-11页

作者： Mohaddese Mahboubi Medicinal Plants Research Department Research and DevelopmentTabibDaru Pharmaceutical CompanyKashanIran

carum carvi or caraway is traditionally used for treatment of indigestion,pneumonia,and as appetizer,galactagogue,and *** oil,fixed oil and many other valuable extractive compounds with industrial applications are prepared from *** review article has new deep research on caraway as medicinal *** preparing the manuscript,the information was extracted from accessible international databases(Google scholar,PubMed,Science direct,Springer,and Wiley),electronic resources and traditional books by key word of caraway or carum *** results of traditional studies exhibited that the galactagogue and carminative effects of caraway fruits are superior to other ***,the traditional scholars used it as appetizer,while caraway was the main ingredient of anti-obesity drugs in traditional medicine,which has been confirmed in two modern clinical trials of human *** oil in combination with peppermint oil or menthol is used for treatment of functional dyspepsia in clinical *** oil topically on abdomen relieves the IBS symptoms in ***,the use of caraway oil is not recommended in adults under 18 years due to insufficient data,but it can topically use as anti-colic and carminative agent in children or *** antiaflatoxigenic,antioxidant and antimicrobial effects of caraway oil along with its reputation as spice help the industries to use it as natural preservatives and antioxidant agents.

关键词： Caraway carum carvi Obesity Functional dyspepsia Preservative Carvone Limonene

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