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Osteopontin(OPN)alleviates the progression of osteoarthritis by promoting the anabolism of chondrocytes

Genes & Diseases 2023年第4期10卷 1714-1725页

作者： Wei Luo Zili Lin Yuhao Yuan Ziyi Wu Wei Zhong Qing Liu Department of Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China

Osteoarthritis(OA)is a chronic debilitating joint disease,characterized by degen-eration of the cartilage and loss of the cartilage matrix,and it is clinically manifested as joint ***(OPN)is a glycoprotein that is abnormally expressed in the bone and carti-lage tissues and plays a vital role in various pathological processes such as the osteoarthritic inflammatory response and endochondral *** focus of our study is to investigate the therapeutic potential and specific role of OPN in *** morphological comparisons,we found that the cartilage was severely worn-out and there was a significant loss of the cartilage matrix in ***,CD44,and hyaluronic acid(HA)synthase 1(HAS1)were highly expressed,and the anabolism of HA was significantly higher in the OA chondrocytes than in the control ***,we treated the OA chondrocytes with small interfering RNA(siRNA)targeting OPN,recombinant human OPN(rhOPN),and a combination of rhOPN and anti-CD44 ***,in vivo experiments were performed in *** found that OPN up-regulated the expression of downstream HAS1 and increased the anabolism of HA through CD44 protein expression in OA mice compared with those in control ***,intra-articular injection of OPN in mice with OA significantly inhibited OA *** summary,OPN ini-tiates an intracellular cascade via CD44 which results in an anabolic increase in HA levels,thereby inhibiting OA ***,OPN is a promising therapeutic agent in precision treatment of OA.

关键词： cartilage degeneration CD44 Hyaluronic acid Osteoarthritis Osteopontin

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Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits

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Journal of Traditional Chinese Medicine 2017年第3期37卷 404-411页

作者： Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher Department of Acupuncture&Moxibustion People's Liberation Army General HospitalBeijing 100853China Instituteof Orthopedics People's Liberation Army General HospitalBeijing 100853China Research Unit for Complementary and Integrative Laser Medicine Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicineand Traditional Chinese Medicine Research Center GrazMedical University of Graz8036 GrazAustria Institute of Experimental and Clinical Pharmacology Medical University of Graz8036 GrazAustria

OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical ***: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF.

关键词： Osteoarthritis, knee Acupuncture appa-ratus Hyaluronic acid Vascular endothelial growthfactors Venous stasis cartilage degeneration

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Osteopontin inhibits osteoarthritis progression via the OPN/CD44/PI3K signal axis

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Genes & Diseases 2022年第1期9卷 128-139页

作者： Qing Liu Hao Zeng Yuhao Yuan Zhiwei Wang Ziyi Wu Wei Luo Department of Orthopaedics Xiangya HospitalCentral South University87th Xiangya RoadChangshaHunan 410008PR China Department of Spine Surgery The Second Xiangya HospitalCentral South University139th Renmin Middle RoadChangshaHunan 410011PR China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA

Chondrocyte degeneration and extracellular matrix component loss are the primary causes of osteoarthritis(OA).OA can be treated by inhibiting chondrocyte degeneration and increasing extracellular matrix component ***(OPN),a multifunctional protein,has gained immense attention with regard to its involvement in *** study aimed to explore the therapeutic value and mechanism of action of OPN in OA *** of the histomorphological analysis revealed a worn-off OA cartilage tissue surface,cartilage matrix layer deterioration,and calcium salt *** to that in normal chondrocytes,in OA chondrocytes,the OPN,CD44,and PI3K protein and mRNA expression was ***,siOPN,rhOPN,and rhOPN plus LS-C179404 interfered with OA *** verified in mice,OPN directly inhibited the expression level of PI3K in OA chondrocytes by binding with *** analysis of the knee joints demonstrated that OPN effectively inhibited OA progression via the OPN/CD44/PI3K signal *** conclusion,OPN activates intracellular PI3K signaling molecules by binding to CD44 on the cell surface to cause downstream cascading effects,thereby delaying chondrocyte degeneration and reducing cartilage matrix component loss;therefore,OPN is a potential therapeutic agent for OA.

关键词： cartilage degeneration cartilage matrix CD44 Osteoarthritis Osteopontin Phosphatidylinositol-3-kinase

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Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

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Frontiers of Nursing 2018年第2期5卷 91-96页

作者： Peng-Fei Han Zhi-Liang Zhang Tao-Yu Chen Rui-Peng Zhao Rong Zhang Xiao-Dong Li Peng-Cui Li Lei Wei Zhi Lv Xiao-Chun Wei Second People's Hospital of Changzhi City ChangzhiShanxi 046010China Second Affiliated Hospital of Shanxi Medical University TaiyuanShanxi 030001China Affiliated Peace Hospital of Changzhi Medical College ChangzhiShanxi 046010China

The main pathological change in post-traumatic osteoarthritis （PTOA） is cartilage degeneration, which is closely related to inflammation and oxidative stress. Inflammation can cause degeneration of articular cartilage. cartilage degeneration can also stimulate the progression of inflammation. It has been found that inflammatory cytokines can participate in the pathological process of cartilage degeneration through multiple signaling pathways, mainly mitogen-activated protein kinase, nuclear transcription factor kappa B, and Wnt-p-catenin signal transduction pathways. This review aimed at exploring the relationship between PTOA and inflammation-related cytokines by introducing the role of proinflammatory cytokines in chondrocyte destruction and extracellular matrix degradation.

关键词： post-traumatic osteoarthritis cartilage degeneration pminflammatory cytokine signaling pathway

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Umbilical cord as a mesenchymal stem cell source for treating joint pathologies

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World Journal of Orthopedics 2011年第6期2卷 43-50页

作者： María Carmen Arufe Alexandre De la Fuente Isaac Fuentes Francisco Javier De Toro Francisco Javier Blanco Department of Medicine Area of Anatomy and Human EmbryologyCampus Oza s/nFac.of Health ScienceUniversity of A Coruna15006 A CorunaSpain Osteoarticular and Aging Research Lab Cellular Therapy UnitINIBIC-CH Universitario A Coruna15006 A CorunaSpain Rheumatology Division INIBIC-CH Universitario A Coruna15006 A CorunaSpain Cathedra Bioiberica Universidad de A Coruna15006 A CorunaSpain CIBER-BBN-Instituto de Salud Carlos III 15006 A CorunaSpain Centro de Investigacion Biomedica Hospital Universitario A CorunaC/Xubias 8415006 A CorunaSpain

Articular cartilage disorders and injuries often result in life-long chronic pain and compromised quality of ***,the regeneration of articular cartilage is a continuing challenge for biomedical *** of the most promising therapeutic approaches is cellbased tissue engineering,which provides a healthy population of cells to the injured site but requires differentiated chondrocytes from an uninjured *** use of healthy chondrocytes has been found to have limitations.A promising alternative cell population is mesenchymal stem cells(MSCs),known to possess excellent proliferation potential and proven capability for differentiation into ***“immunosuppressive”property of human MSCs makes them an important candidate for allogeneic cell *** use of allogeneic MSCs to repair large defects may prove to be an alternative to current autologous and allogeneic tissue-grafting *** allogeneic cell-based approach would enable MSCs to be isolated from any donor,expanded and cryopreserved in allogeneic MSC banks,providing a readily available source of progenitors for cell replacement *** possibilities have spawned the current exponential growth in stem cell research in pharmaceutical and biotechnology *** objective in this review is to summarize the knowledge about MSCs from umbilical cord stroma and focus mainly on their applications for joint pathologies.

关键词： Human Mesenchymal stem cell Umbilical cord cartilage degeneration

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