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Serum concentration of sFas and sFasL in healthy HBsAg carriers,chronic viral hepatitis B and C patients

World Journal of Gastroenterology 2004年第24期10卷 3650-3653页

作者： Tadeusz Wojciech Lapinski Oksana Kowalczuk Danuta Prokopowicz Lech Chyczewski Department of Infectious Diseases Medical University of BialystokPoland Institute of Molecular Biology Medical University of BialystokPoland

AIM:To estimate the amount of apoptosis among healthy HBsAg carriers,patients with chronic HBV infection treated wibh lamivudine and patients with chronic HCV infection treated with interferon alpha and *** of apoptosis was evaluated by serum sFas/sFasL concentration measurement. Moreover dependence between apoptosis and HBV-DNA or HCV-RNA levels was studied. METHODS:Eighty-six persons were included into study:34 healthy HBsAg carders,33 patients with chronic HBV infecl^on and 19 patients with chronic HCV *** levels of sFas/sFasL were measured by ELISA ***-DNA and HCV-RNA were measured by RT-PCR *** of sFas/sFasL were determined before and 2 and 12 wk after therapy in patients with chronic hepatitis B and C infection. HBV-DNA or HCV-RNA was detected before treatment and 6 mo after treatment. RESULTS:Twenty-four (71%) healthy HBsAg carders showed HBV-DNA over 10~5/mL,which was comparable to the patients with chronic hepatitis *** from HBV-DNA levels, the concentration of sFas among healthy HBsAg carders was comparable to healthy *** patients with chronic hepatitis B and C,the concentration of sFas was significantly higher in comparison to healthy HBsAg carriers and healthy *** chronic hepatitis B patients the concentration of sFas was decreased during lamivudine *** chronic hepatitis C patients the concentration of sFas was increased during IFN alpha and ribavirin treatment,sFasL was not detected in control *** sFasL occurred more frequently in chronic hepatitis C patients in comparison to chronic hepatitis B patients. CONCLUSION:There are no correlations between apoptosis and HBV-DNA *** ther is an association between apoptosis and activity of inflammation in patients with chronic HBV *** can be increased in patients with chronic hepatitis C by effective treatment which may be a result of apoptosis stimulation by IFN-α.

关键词： Adolescent Adult Aged Antigens, CD95 Apoptosis Biological Markers carrier state DNA, Viral Female Hepatitis B Surface Antigens Hepatitis B, Chronic Hepatitis C, Chronic Humans Lamivudine Male Membrane Glycoproteins Middle Aged RNA, Viral Reverse Transcriptase Inhibitors Solubility

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EFFECTS OF ACUPUNCTURE ON THE IMMUNOLOGICAL FUNCTIONS IN HEPATITIS B VIRUS carrierS

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Journal of Traditional Chinese Medicine 1999年第4期19卷 268-272页

作者：陈家福陈民赵斌王英毛树章 The First Municipal Hospital Zhuzhou 412000Hunan Province

A contrast study on the effects of manual acupuncture and electroacupuncture wasconducted in 60 cases of chronic hepatitis B *** results demonstrated that theimmunological functions,both cellular and humoral,were markedly regulated asevidenced by the negative turnover rates of HBsAg,HBeAg,anti-HBc and HBcAg,as wellas the positive turnover rate of anti-HBe.

关键词： Acupuncture Therapy Electroacupuncture Adolescent Adult CD4-CD8 Ratio carrier state Complement C3 Female Hepatitis B Hepatitis B Antibodies Hepatitis B Surface Antigens Humans Immunoglobulin A Immunoglobulin G Male

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正常人与乙型肝炎病毒慢性携带者中乙型肝炎疫苗的血清学效果的观察

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延边大学医学学报 1986年第1期 29-31页

作者：徐龙国朴花顺崔贞玉延边医学院附属医院预防保健科

给61例正常人和33例HBV慢性携带者接种乙肝疫苗,后半年内检测了一些血清学指标。正常人接种疫苗后1,3,6个月时抗—HBs阳性率分别为27.8％,85.2％和90.1％。HBV携带者接种疫苗后6个月HBsAg滴度上升者8例,下降者4例,仅有1例抗—HBs阳性,12... 详细信息

给61例正常人和33例HBV慢性携带者接种乙肝疫苗,后半年内检测了一些血清学指标。正常人接种疫苗后1,3,6个月时抗—HBs阳性率分别为27.8％,85.2％和90.1％。HBV携带者接种疫苗后6个月HBsAg滴度上升者8例,下降者4例,仅有1例抗—HBs阳性,12例HBeAg阳性者中仅有1例抗—HBe阳性。所有病例接种疫苗后无明显不良反应。结果说明本疫苗抗原性良好,但对HBsAg携带者无效。

关键词： hepatitis B vaccination carrier state hepatitis B antibodies hepatitis B surface antigen

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