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World Journal of Diabetes 2017年第1期8卷 18-27页

作者： Kristina S Petersen Jennifer B Keogh Peter J Meikle Manohar L Garg Peter M Clifton School of Pharmacy and Medical Sciences University of South Australia Baker IDI Heart and Diabetes Institute Nutraceuticals Research Group University of NewcastleCallaghan

AIM To determine the clinical and dietary predictors of common carotid artery intima media thickness(CCA IMT) in a cohort of subjects with type 1 and type 2 diabetes. METHODS Participants with type 1(n = 23) and type 2 diabetes(n = 127) had mean and mean maximum CCA IMT measured using B mode ultrasound. Dietary intake was measured using a food frequency questionnaire. Clinical and dietary predictors of mean and mean maximum CCA IMT were determined using linear regression analysis adjusted for potential confounders. RESULTS The main predictors of mean and mean maximum CCA IMT were age and weight. After multivariate adjustment there were no dietary predictors of CCA IMT. However,in subjects that were not prescribed a lipid lowering medication alcohol consumption was positively associated with CCA IMT after multivariate adjustment. No difference existed in CCA IMT between subjects with type 1 or type 2 diabetes once age was adjusted for. CONCLUSION CCA IMT was predominantly predicted by age and weight in these subjects with diabetes. The finding that CCA IMT was not different between people with type 1 and type 2 diabetes warrants further investigation in a larger cohort.

关键词： Diabetes Carotid intima media thickness Arterial structure Diet Lipidomics carotenoids

Regulatory mechanisms of rapeseed petal color formation:Current research status and future perspectives

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Oil Crop Science 2022年第4期7卷 174-179页

作者： Shijun Li Tao Chang Xi Li Zechuan Peng Chunyun Guan Mei Guan National Oil Crops Improvement Center in Hunan Department of AgronomyHunan Agricultural UniversityChangsha410128China

Flower color,an important rapeseed character,has great practical value and research *** has become an area of intensive research in recent *** paper summarizes the latest research progress on rape flower color in terms of variety,source,pigment composition,formation mechanism,and ***,it provides an overview of rape flower color breeding and omics.

关键词： Rape Flower color carotenoids Flavonoids Omics

Marine yeast Rhodotorula paludigena VA 242 a pigment enhancing feed additive for the Ornamental Fish Koi Carp

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Aquaculture and Fisheries 2024年第1期9卷 66-70页

作者： R.Rekha K.A.Nimsi K.Manjusha T.K.Sirajudheen Faculty of Ocean Science&Technology Kerala University of Fisheries and Ocean Studies(KUFOS)CochinKerala682506India

Skin colour is an important criterion in determining the aesthetic appeal of ornamental fishes,and thus their market *** the pigment enhancement in ornamental fishes has been the subject of extensive research by using various synthetic as well as natural pigment *** composition is one of the most important elements that influence the development of pigmentation in *** study is an attempt to assess the possibility of using carotenogenic marine yeast as pigment enhancer in fish diet for Koi carp,Cyprinus *** 60 days feeding experiment was done by using feed incorporated with mangrove associated marine yeast Rhodotorula paludigena *** pigmentation in the scales of fishes fed with experimental feed was observed than that fed with the control diet(normal pellet feed).Furthermore the improved growth rate and general wellbeing in fishes fed with experimental feed provides scope for further studies in this field with respect to the growth and survival of fishes.

关键词： Marine yeasts carotenoids Ornamental fishes Pigment enhancer Feed additive Rhodotorula sp

ABA and GA_(3)affect the growth and pigment composition in Andrographis paniculata *** Nees.,an important folk herb

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Frontiers in Biology 2009年第3期4卷 337-341页

作者： M.GOMATHINAYAGAM V.E.ANURADHA Changxing ZHAO Gloria A.AYOOLA C.Abdul JALEEL R.P.ANNEERSELVAM Stress Physiology Lab Department of BotanyAnnamalai UniversityTamil NaduIndia College of Agronomy and Plant Protection Qingdao Agricultural UniversityChunyang RoadChengyang DistrictQingdao 266109China Department of Pharmaceutical Chemistry Faculty of PharmacyUniversity of Lagos CMUL CampusIdi-ArabaLagosNigeria DMJM International(Cansult Maunsell/AECOM Ltd.) Consultant of Gardens Sector ProjectsAlain Municipality and Eastern EmiratesP.O.Box 1419Al-AinAbu DhabiUnited Arab Emirates

In this study,5μmol·L^(-1)abscisic acid(ABA)and gibberellic acid(GA3)were used to study the effect of both growth regulators on the morphological parameters and pigment composition of Andrographis *** growth regulators were applied by means of foliar spray during morning *** treatment inhibited the growth of the stem and internodal length when compared with control,whereas GA3 treatment increased the plant height and internodal *** total number of leaves per plant decreased in the ABA-treated plants,but GA3 treatment increased the total number of leaves when compared with the *** growth regulators(ABA and GA3)showed increased leaf *** and GA3 treatments slightly decreased the total root growth at all the stages of *** growth regulator treatments increased the whole plant fresh and dry weight at all stages of *** enhanced the fresh and dry weight to a larger extent when compared with *** increase in the total chlorophyll content was recorded in ABA and GA3 *** chlorophyll-a,chlorophyll-b,and carotenoids were increased by ABA and GA3 treatments when compared with the control *** xanthophylls and anthocyanin content were increased with ABA and GA3 treatments in *** plants.

关键词： Andrographis paniculata chlorophyll growth xanthophylls anthocyanin carotenoids

Enhanced Carotenoid Production by a Mutant of the Marine Yeast Rhodotorula sp. hidai

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Journal of Ocean University of China 2007年第1期6卷 66-71页

作者： CONG Li CHI Zhenming LI Jing WANG Xianghong UNESCO Chinese Center of Marine Biotechnology Ocean University of ChinaQingdao 266003P.R.China

After a serial of UV, EMS and NTG mutagenesis, a mutant named MM of the red marine yeast strain Rhodotorula sp. hidai was obtained. The mutant MM could produce 603.93 μg g-1 of carotenoid within 5 days in the medium containing 4.0 g sucrose, 1.5 g yeast extract, 0.1 g MgSO4, and 100 mL of sea water, with pH 6.0 and at 30 ℃, while only 213.18 μg g-1 of carotenoid was pro-duced by the wild type under the same conditions.

关键词： red marine yeasts Rhodotorula sp.hidai carotenoids fermentation

A pilot study for distinguishing basal cell carcinoma from normal human skin tissues using visible resonance Raman spectroscopy

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Journal of Cancer Metastasis and Treatment 2019年第1期4卷 41-54页

作者： Cheng-hui Liu Binlin Wu Laura ASordillo Susie Boydston-White Vidyasagar Sriramoju ChunyuanZhang Hugh Beckman Lin Zhang Zhe Pei Lingyan Shi Robert RAlfano Institute for Ultrafast Spectroscopy and Lasers The City College of the City University of New YorkNew YorkNY 10031USA Physics Department and CSCU Center for Nanotechnology Southern Connecticut State UniversityNew HavenCT 06515USA Department of Electrical Engineering The Grove School of EngineeringThe City College of the City University of New YorkNew YorkNY 10031USA Science Department City University of New YorkBorough of Manhattan Community CollegeNew YorkNY 10007-1097USA Bermuda Village Dr. Boca RatonFlorida 33487-1041USA517150 Department of Chemistry Columbia UniversityNew YorkNY 10027USA

Aim: The aim of the study is to test visible resonance Raman (VRR) spectroscopy for rapid skin cancer diagnosis,and evaluate its effectiveness as a new optical biopsy method to distinguish basal cell carcinoma (BCC) from normal skin ***: The VRR spectroscopic technique was undertaken using 532 nm excitation. Normal and BCC human skin tissue samples were measured in seconds. The molecular fingerprints of various native biomolecules as biomarkers were analyzed. A principal component analysis - support vector machine (PCA-SVM) statistical analysis method based on the molecular fingerprints was developed for differentiating BCC from normal skin ***: VRR provides a rapid method and enhanced Raman signals from biomolecules with resonant and nearresonant absorption bands as compared with using a near-infrared excitation light source. The VRR technique revealed chemical composition changes of native biomarkers such as tryptophan, carotenoids, lipids and *** VRR spectra from BCC samples showed a strong enhancement in proteins including collagen type I combined with amide I and amino acids, and a decrease in carotenoids and lipids. The PCA-SVM statistical analysis based on the molecular fingerprints of the biomarkers yielded a 93.0% diagnostic sensitivity, 100% specificity, and 94.5%accuracy compared with histopathology ***: VRR can enhance molecular vibrational modes of various native biomarkers to allow for very fast display of Raman modes in seconds. It may be used as a label-free molecular pathology method for diagnosis of skin cancer and other diseases and be used for combined treatment with Mohs surgery for BCC.

关键词： Visible resonance Raman spectroscopy human skin basal cell carcinoma principal componentanalysis supports vector machine molecular fingerprints tryptophan carotenoids

THE BIOGEOCHEMISTRY OF PHOTOSYNTHETIC PIGMENTS IN THE JIULONG RIVER ESTUARY AND WESTERN XIAMEN BAY

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Chinese Journal of Oceanology and Limnology 2001年第2期19卷 164-171页

作者：徐立洪华生王海黎陈伟琪 Res. Lab. of SEDC of MEE ESRC Xiamen University Xiamen China

High performance liquid chromatography (HPLC) analysis of photosynthetic pigments in samples from Western Xiamen Bay and the Jiulong River Estuary showed that their major carotenoids were fucoxanthin, peridinin, zeaxanthin, violaxanthin, and diadinoxanthin. Diatoms dominated in the spring bloom, dinoflagellates in summer. Violaxanthin and chlorophyll b indicated the appearance of chrysophytes and green algae, most of which were freshwater species. The high phytoplankton biomass region was located at the inner part of the bay. Diatoms and dinoflagellates dominated phytoplankton communities, contributing to over 50% of total biomass. All the main diagnostic carotenoids were significantly (P<0.01) correlated negatively to dissolved inorganic phosphorus, suggesting that they were limited by phosphorus. The high negative linear relationship (P<0.0001) between dissolved inorganic phosphorus and peridinin (dinoflagellates indicator) implied the potential of dissolved inorganic phosphorus for triggering red tide events in this region.

关键词： pigments chlorophyll carotenoids estuary Xiamen Bay

BIOREACTOR TECHNOLOGY FOR PRODUCTION OF VALUABLE ALGAL PRODUCTS

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Chinese Journal of Oceanology and Limnology 1998年第S1期16卷 84-90页

作者：陈峰 1. Department of Botany The University of Hong Kong Pokfulam Road Hong Kong

Bioreactor technology has long been employed for the production of various (mosilycheap) food and pharmaceutical products. More recently, research has been mainly focused on the devel-opment of novel bioreactor technology for the production of high - value products. This paper reports theemployment of novel bioreactor technology for the production of high-value biomass and metabolites by mi-croalgae. These high-value products include microalgal biomass as health foods, pigments including phy-cocyanin and carotenoids, and polyunsaturated fatty acids such as eicosapentaenoic acid and docsahex-aenoic acid. The processes involved include heterotrphic and mixotrophic cultures using organic sub-strates as the carbon source. We have demonstrated that these bioreactor cultivation systems are particu-larly suitable for the production of high-value products from various microalgae. These cultivation systemscan be further modified to improve cell densities and productivities by using high cell density techniquessuch as fed-batch and membrane cell recycle systems. For most of the microalgae investigated, the maxi-mum cell concentrations obtained using these bioreactor systems in our laboratories are much higher thanany so far reported in the literature.

关键词： bioreactor microalgae high-value products carotenoids fatty acids phycocyanin lutein

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类胡萝卜素产生菌Hm68的诱变和选育

杭州教育学院学报 1998年第3期2卷 41-44页

作者：陈敏

类胡萝卜素产生菌Ｈｍ６８的诱变和选育陈敏（生物系）摘要本文初步研究了类胡萝卜素高产菌株的选育方法。通过用亚硝基胍（ＮＴＧ）处理出发菌株Ｈｍ６８的细胞，经筛选得到一株变异株Ｈｍ６８－５，色素产率达到７３０μｇ／ｇ，较... 详细信息

类胡萝卜素产生菌Ｈｍ６８的诱变和选育陈敏（生物系）摘要本文初步研究了类胡萝卜素高产菌株的选育方法。通过用亚硝基胍（ＮＴＧ）处理出发菌株Ｈｍ６８的细胞，经筛选得到一株变异株Ｈｍ６８－５，色素产率达到７３０μｇ／ｇ，较出发菌株提高３０％．关键词诱变，类...

关键词： carotenoids mutation.

Recent progress on mechanisms that allocate cellular space to plastids

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Fundamental Research 2024年第5期4卷 1167-1170页

作者： Robert M.Larkin Key Laboratory of Horticultural Plant Biology Ministry of EducationCollege of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China

Mechanisms that allocate cellular space to organelles are of fundamental importance to biology but remain poorly understood.A detailed understanding of mechanisms that allocate cellular space to plastids,such as chloroplasts,will lead to high-yielding crops with enhanced nutritional *** HIGH PIGMENT(HP)genes in tomato contribute to regulated proteolysis and abscisic acid *** HP1 gene was the first gene reported to influence the amount of cellular space occupied by chloroplasts and chromoplasts almost 20 years ***,our knowledge of mechanisms that allocate cellular space to plastids was enhanced by new information on the influence of cell type on the amount of cellular space occupied by plastids and the identification of new genes that help to allocate cellular space to *** genes encode proteins with unknown and diverse biochemical *** transcription factors were recently reported to regulate the numbers and sizes of chloroplasts in fleshy *** these transcription factors do not induce compensating effects on cell size,they should affect the amount of cellular space occupied by *** we can now propose more detailed models for the network that allocates cellular space to plastids,many gaps remain in our knowledge of this network and the genes targeted by this ***,these recent breakthroughs provide optimism for future progress in this field.

关键词： Plastid Chloroplast Chromoplast Chloroplast proliferation Chloroplast coverage Chlorophyll carotenoids