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Large animal models of cardiac ischemia-reperfusion injury:Where are we now?

Zoological Research 2023年第3期44卷 591-603页

作者： Attaur Rahman Yuhao Li To-Kiu Chan Hui Zhao Yaozu Xiang Xing Chang Hao Zhou Dachun Xu Sang-Bing Ong Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina Centre for cardiovascular Genomics and Medicine(CCGM) Lui Che Woo Institute Innovative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina College of Veterinary Sciences and Animal Husbandry Abdul Wali Khan University MardanMardanKhyber Pakhtunkhwa 23200Pakistan School of Biomedical Sciences CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina Institute for Tissue Engineering and Regenerative Medicine(iTERM) The Chinese University of Hong Kong(CUHK)Hong Kong SARChina SBS Core Laboratory CUHK Shenzhen Research InstituteShenzhenGuangdong 518172China Kunming Institute of Zoology–The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Shanghai East Hospital Key Laboratory of Arrhythmias of the Ministry of Education of ChinaSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China Department of Cardiology Chinese People’s Liberation Army General HospitalBeijing 100853China Center for cardiovascular Research and Alternative Medicine University of Wyoming College of Health SciencesLaramieWY 82071USA Department of Cardiology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Hong Kong Hub of Paediatric Excellence(HK HOPE) Hong Kong Children’s Hospital(HKCH)Kowloon BayHong Kong SARChina CUHK Shenzhen Research Institute(SZRI) ShenzhenGuangdong 518172China Neural Vascularand Metabolic Biology Thematic Research ProgramSchool of Biomedical SciencesThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical ***,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models,which are not transferable or reproducible in large animal models due to different factors such as:(i)complex and varied features of human ischemic cardiac disease(ICD),which are challenging to mimic in animal models,(ii)significant differences in surgical techniques applied,and(iii)differences in cardiovascular anatomy and physiology between small versus large *** article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI),as well as the different methods used to induce and assess IRI,and the obstacles faced in using large animals for translational research in the settings of cardiac IR.

关键词： cardiovascular disorder Ischemic cardiac disease Ischemic-reperfusion injury Large animal model Myocardial infarction Translational gap

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Relationship between obstructive sleep apnea hypopnea syndrome and cardiovascular disorders in adult snorers

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Journal of Nanjing Medical University 2009年第1期23卷 59-63页

作者： Rui Wu Xilong Zhang Ling Hu Enzhi Jia Department of Respiratory Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Objective：To investigate the relationship between sleep apnea hypopnea syndrome（OSAHS） and some cardiovascular disorders in adult habitual snorers as well as the effectiveness of nasal continuous positive airway pressure（NCPAP） on those with OSAHS. Methods： With the use of polysomnography, 262 adult habitual snorers were examined and divided into the OSAHS group and the Non-OSAHS group （control）. Using ambulatory electrocardiogram and blood pressure measurement, daily nocturnal rhythm of blood pressure, hypertension, heart rate variability, some arrythmias and angina pectoris of coronary heart disease were monitored and compared between the two groups, before and after 14 days of treatment with NCPAP in the OSAHS group. *** study indicated a higher incidence （39.6%） of OSAHS in adult snorers and demonstrated that there was a significantly higher incidence of hypertension, disappearance of the daily nocturnal rhythm of blood pressure, poor effectiveness of nitrate on angina pectoris of coronary heart disease, decreased heart rate variability during sleep, increased arrythmias and lower SpO2 levels in the OSAHS group than in the Non-OSAHS group. After NCPAP treatment during sleep, snoring control, significantly higher SpO2 and lower apnea hypopnea indices were achieved in the OSAHS group; heart rate variability and daily nocturnal rhythm of blood pressure returned to normal levels. Conclusion：The results of this research suggested that there was a close relationship between the development of OSAHS and some cardiovascular disorders. Furthermore, NCPAP treatment was effective not only on OSAHS but also on coexisting cardiovascular disorders.

关键词： Obstructive sleep apnea hypopnea syndrome cardiovascular disorder snoring

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