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Protective effect of cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 939-944页

作者： Chinnadurai Veeramani Khalid S Al-Numair Mohammed A Alsaif Govindasamy Chandramohan Nouf S Al-Numair Kodukkur Viswanathan Pugalendi Department of Community Health Sciences College of Applied Medical SciencesKing Saud University Department of Structural and Molecular Biology University College LondonDarwin BuildingCower StreetLondonWCIE 6BT Department of Biochemistry and Biotechnology Annamalai University

Objective:To investigate the protective role of cardiospermum halicacabum(***) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic ***: Diabetes was induced in male albino Wistar rats by intraperitonial administration of *** *** leaf extract(CHE) was administered orally to normal and STZ-diabetic rats for 45 *** effects of *** leaf extract(CHE) on plasma and tissue glycoproteins (hexose,hexosamine,fucose and sialic acid) were ***:The levels of plasma and tissues glycoproteins containing hexose,hexosamine and fucose were significantly increased in STZ-induced diabetic *** addition,the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic *** administration of CHE to diabetic rats,the metabolic alteration of glycoprotein reverted towards normal levels. Conclusions:The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.

关键词： Streptozotocin cardiospermum halicacabum leaf extract Hexose Hexosamine Fucose Sialic acid

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Repellent properties of cardiospermum,halicacabum Linn.(Family:Sapindaceae)plant leaf extracts against three important vector mosquitoes

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 602-607页

作者： M Govindarajan R Sivakumar Division of Vector Biology and Phytochemistry Department of ZoologyAnnamalai University

Objective:To determine repellent activity of hexane,ethyl acetate,benzene,chloroform and methanol extract of cardiospermum halicacabum,(***) against Culex quinque/ascialus(***),Aedes aegypti(***) and Anopheles slephensi(***). Methods:Evaluation was carried out in a net cage(45 cm×30 cm×25 cm) containing 100 blood starved female mosquitoes of three mosquito species and were assayed in the laboratory condition by using the protocol of WHO 2005;The plant leaf crude extracts of *** was applied at 1.0,2.5,and 5.0 me/cm^2 separately in the exposed area of the fore *** ethanol served as ***:In this observation,the plant crude extracts gave protection against mosquito bites without any allergic reaction to the test person,and also,the repellent activity was dependent on the strength of the plant *** tested plant crude extracts had exerted promising repellent against all the three ***:From the results it can be concluded the crude extract of *** was potential for controlling ***, *** and *** mosquitoes.

关键词： Repellency cardiospermum halicacabum Culex quinquefasciatus Aedes aegypti Anopheles stephensi

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