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Hydrogen Sulfide Regulating Myocardial Structure and function by Targeting Cardiomyocyte Autophagy

Chinese Medical Journal 2018年第7期131卷 839-844页

作者： Qing-You Zhang Hong-Fang Jin Selena Chen Qing-Hua Chen Chao-Shu Tang Jun-Bao Du Ya-Qian Huang Department of Pediatrics Peking University First Hospital Beijing 100034 China Division of Biological Sciences University of California San Diego La Jolla California 92093 USA Small Gaseous Molecules and Cardiovascular Disease Section Key Laboratory of Molecular Cardiology Ministry of Education Beijing 100191 China Department of Physiology and Pathophysiology Health Sciences Center Peking University Beijing 100191 China

Objective： Hydrogen sulfide （H2S）, a gaseous signal molecule, plays a crucial role in many pathophysiologic processes in the cardiovascular system. Autophagy has been shown to participate in the occurrence of many cardiac diseases. Increasing evidences indicated that H,S regulates myocardial structure and function in association with the altered autophagy and plays a ＂switcher＂ role in the autophagy of myocardial diseases. The airn of this review was to summarize these insights and provide the experimental evidence that H2S targets cardiomyocyte autophagy to regulate cardiovascular function. Data Sources： This review was based on data in articles published in the PubMed databases up to October 30, 2017, with the following keywords：＂hydrogen sulfide,＂＂autophagy,＂ and ＂cardiovascular diseases.＂ Study Selection： Original articles and critical reviews on H,S and autophagy were selected for this review. Results： When autophagy plays an adaptive role in the pathogenesis of diseases, H2S restores autophagy; otherwise, when autophagy plays a detrimental role, H2S downregulates autophagy to exert a cardioprotective function. For example, H2S has beneficial effects by regulating autophagy in myocardial ischemia/reperfusion and plays a protective role by inhibiting autophagy during the operation of cardioplegia and cardiopuhnonary bypass. H2S postpones cardiac aging associated with the upregulation of autophagy but improves the left ventricular function of smoking rats by lowering autophagy. Conclusions： H2S exerts cardiovascular protection by regulating autophagy. Cardiovascular autophagy would likely become a potential target of H2S therapy for cardiovascular diseases.

关键词： Autophagy cardioprotective function Cardiovascular System Hydrogen Sulfide

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