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stem cell therapies in cardiac diseases: Current status and future possibilities

World Journal of stem cells 2021年第9期13卷 1231-1247页

作者： Tais Hanae Kasai-Brunswick Adriana Bastos Carvalho Antonio Carlos Campos de Carvalho National Center of Structural Biology and Bioimaging Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil National Institute of Science and Technology in Regenerative Medicine Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil Carlos Chagas Filho Institute of Biophysics Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil

Cardiovascular diseases represent the world’s leading cause of death. In thisheterogeneous group of diseases, ischemic cardiomyopathies are the mostdevastating and prevalent, estimated to cause 17.9 million deaths per *** all biomedical efforts, there are no effective treatments that can replacethe myocytes lost during an ischemic event or progression of the disease to heartfailure. In this context, cell therapy is an emerging therapeutic alternative to treatcardiovascular diseases by cell administration, aimed at cardiac regeneration andrepair. In this review, we will cover more than 30 years of cell therapy in cardiology,presenting the main milestones and drawbacks in the field and signalingfuture challenges and perspectives. The outcomes of cardiac cell therapies arediscussed in three distinct aspects: The search for remuscularization byreplacement of lost cells by exogenous adult cells, the endogenous stem cell era,which pursued the isolation of a progenitor with the ability to induce heart repair,and the utilization of pluripotent stem cells as a rich and reliable source ofcardiomyocytes. Acellular therapies using cell derivatives, such as microvesiclesand exosomes, are presented as a promising cell-free therapeutic alternative.

关键词： stem cell cell therapy cardiac stem cell Cardiovascular diseases Progenitor cardiac cells Pluripotent stem cells

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The therapeutic potential of stem cell therapy for myocardial infraction

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Life Research 2021年第4期4卷 25-32页

作者： Harshawardhan Dhanraj Ramteke Shubham Suhas Mahamuni Purvesh R Kolhadiya School of International Education Anhui Medical UniversityHefeiChina. CHL Multispecialty Hospital and Research Centre ChandrapurIndia.

It has been researched that myocardial infarction(MI)has drastically affected patients all over the *** current guidelines of the medical treatments including PTCA or CABG just improve the condition and reduce damage to an *** the new studies and recent updates on myocardial stem cells,it has been researched that myocardial stem cells have regenerative *** cell therapy used in cardiac disease management shows a promising and novel approach for cardiac tissues,cardiac muscle repair,and ***,it’s been observed that the stem cell-derived paracrine factors help in regulating and remodeling the coronary artery inflammation and cardiac tissue generation in the MI ***,we highlight recent findings and discuss how they use stem cell therapy during MI and heart disease.

关键词： stem cell therapy myocardial infarction cardiac stem cell transplantation regeneration.

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