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cardiac resident macrophages: Spatiotemporal distribution, development, physiological functions, and their translational potential on cardiac diseases

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1483-1493页

作者： Jing Jin Yurou Wang Yueqin Liu Subrata Chakrabarti Zhaoliang Su International Genome Center Jiangsu UniversityZhenjiang 212013China Institute for Medical Immunology Jiangsu UniversityZhenjiang 212013China Center Laboratory the Fourth People's Hospital of ZhenjiangZhenjiang 212008China Department of Pathology and Laboratory Medicine Western UniversityLondonOntario N6A 5C1Canada

cardiac resident macrophages (CRMs) are the main population of cardiac immune cells. The role of these cells in regeneration, functional remodeling, and repair after cardiac injury is always the focus of research. However, in recent years, their dynamic changes and contributions in physiological states have a significant attention. CRMs have specific phenotypes and functions in different cardiac chambers or locations of the heart and at different stages. They further show specific differentiation and development processes. The present review will summarize the new progress about the spatiotemporal distribution, potential developmental regulation, and their roles in Cardiac development and aging as well as the translational potential of CRMs on cardiac diseases. Of course, the research tools for CRMs, their respective advantages and disadvantages, and key issues on CRMs will further be discussed.

关键词： cardiac resident macrophages Spatiotemporal distribution Cardiac development cardiac homeostasis Physiological functions Research tools Clinical translation Transcriptional characteristics

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Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos

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Journal of Environmental Sciences 2021年第2期33卷 240-249页

作者： Naying Zheng Jinhui Yan Wang Qian Chao Song Zhenghong Zuo Chengyong He State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen 361005China Freshwater Fisheries Research Center Chinese Academy of Fishery SciencesWixi 214081China

Quantum dots(QDs)are new types of nanomaterials.Few studies have focused on the effect of different surface modified QDs on embryonic development.Herein,we compared the in vivo toxicity of Cd Se/Zn S QDs with carboxyl(-COOH)and amino(-NH 2)modification using zebrafish embryos.After exposure,the two Cd Se/Zn S QDs decreased the survival rate,hatching rate,and embryo movement of zebrafish.Moreover,we found QDs attached to the embryo membrane before hatching and the eyes,yolk and heart after hatching.The attached amount of carboxyl QDs was more.Consistently,the Cd content in embryos and larvae was higher in carboxyl QD-treatment.We further observed that the two QDs caused zebrafish pericardial edema and cardiac dysfunction.In line with it,both carboxyl and amino QDs upregulated the transcription levels of Cardiac development-related genes,and the levels were higher in carboxyl QD-treated groups.Furthermore,the chelator of Cd^2+diethylene triamine pentacetate acid could partially rescued the developmental toxicity caused by the two types of QDs suggesting that both the nature of QDs and the release of Cd^2+contribute to the developmental toxicity.In conclusion,the two Cd Se/ZnS QDs have developmental toxicity and affect the Cardiac development,and the carboxyl QDs is more toxic possibly due to the higher affinity and more release to embryos and larvae.Our study provides new knowledge that the surface functional modification of QDs is critical on the development on aquatic species,which is beneficial to develop and applicate QDs more safely and environmentfriendly.

关键词： Quantum dots Surface modification Fish Cardiac development developmental toxicity

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An emerging role for Hippo-YAP signaling in cardiovascular development

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The Journal of Biomedical Research 2014年第4期28卷 251-254页

作者： Jiliang Zhou Department of Pharmacology & Toxicology Medical College of GeorgiaGeorgia Regents UniversityAugustaGA 30912USA

The Hippo signaling pathway was originally discovered in Drosophila and shown to be critical for organ size control and tumorigenesis. This pathway consists of a cascade of kinases and several adaptors that lead to the phosphorylation and inhibition, through nuclear exclusion, of the transcriptional cofactor Yorkie in Drosophila or YAP （yes associated protein） in mammals. Recent studies demonstrate that cardiac-specific deletion of the Hippo pathway kinase Mst （STE20-1ike protein kinases） co-activator WW45 （WW domain-containing adaptor 45）, Mstl, Mst2, or Lats2 （large tumor suppressor homologue 2） in mice result in over-grown hearts with elevated cardiomyocyte proliferation. Consistent with these observations, over-expression of YAP in the mouse embryonic heart increases heart size and promotes cardiac regeneration and contractility after myocardial infarction by inducing cardiomyocyte proliferation, whereas deletion of YAP in the mouse heart impedes cardiomyocyte proliferation, causing myocardial hypoplasia and embryonic or premature lethality. YAP has also been shown to play an important role in the vascular system. Specific-deletion of YAP from vascular smooth muscle cells in mice results in aberrant development of large arteries with a hypoplastic arterial wall phenotype. Hippo-YAP signaling cross-talks with other signaling pathways such as IGF （insulin-like growth factor） and Wnt signaling to promote heart growth by increasing expression of cell cycle genes. The purpose of this review is to summarize these recent findings and discuss potential diagnostic or therapeutic strategies in cardiovascular system based on manipulating the Hippo-YAP signaling.

关键词： Hippo YAP Cardiac development vascular smooth muscle proliferation

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