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cardiac markers: Role in the pathogenesis of arterial hypertension

World Journal of Hypertension 2022年第1期10卷 1-14页

作者： Saira Rafaqat Shaheed Afzal Sana Rafaqat Huma Khurshid Simon Rafaqat Department of Zoology Lahore College for Women UniversityLahore 5400Pakistan Emergency Department of Cardiology Punjab Institute of CardiologyLahore 5400Pakistan Department of Biotechnology Lahore College for Women UniversityLahore 5400Pakistan Department of Business Forman Christian CollegeLahore 5400Pakistan

cardiac biomarkers may play unique roles in the prognostic evaluation of patients with hypertension,as many cardiac biomarker levels become abnormal long before the onset of obvious cardiovascular disease(CVD).There are numerous cardiac ***,this review article only reported the roles of creatinine kinase-MB,cardiac troponins,lipoprotein a,osteopontin,cardiac extracellular matrix,C-reactive protein,cardiac matrix metalloproteinases,cardiac natriuretic peptides,myoglobin,renin,and dynorphin in the pathogenesis of *** article explained recent major advances,as well as discoveries,significant gaps,and current debates and outlined possible directions for future *** studies are required to determine the association between myoglobin and other cardiac markers in ***,therapeutic approaches are required to determine the early control of these cardiac markers,which ultimately reduce the prevalence of CVDs.

关键词： cardiac markers Hypertension Pathogenesis Prevalence Cardiovascular diseases

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Cardioprotective effect of bioassay-guided fractions of Cleome viscosa methanolic extract in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第11期14卷 486-499页

作者： Suresh Yarrappagaari Lavanya Thopireddy Srinivasulu Cheemanapalli Venkata Ramireddy Narala Rajeswara Reddy Saddala Division of Ethnopharmacology Department of BiotechnologySchool of Herbal Studies and Naturo SciencesDravidian UniversityKuppam-517426Andhra PradeshIndia Department of Zoology KVR Government College for WomenKurnool-518004Andhra PradeshIndia Regional Ayurveda Research Institute Itanagar-791111Arumachal PradeshIndia Department of Zoology Yogi Vemana UniversityKadapa-516005Andhra PradeshIndia

Objective:To evaluate the cardioprotective effect of bioassay-guided isolated fractions of Cleome viscosa methanolic extract in streptozotocin-induced diabetic ***:Total phenolics,flavonoids,and in vitro antioxidant activities of the methanolic extract of Cleome viscosa were *** FD-40 fraction from this extract was further evaluated for antihyperglycemic efficacy(insulin and HbA1c),antioxidant activity,and cardioprotective effects(creatine kinase-MB,lactate dehydrogenase,and histopathology)in streptozotocin-induced diabetic *** silico studies were also conducted to assess the bioactivity of ***:Cleome viscosa methanolic extract exhibited the highest antioxidant activity in DPPH,ABTS,H2O2,and FRAP assays compared to other *** with FD-40(40 mg/kg b.w.)isolated from this extract normalized blood glucose,insulin,HbA1c,creatine kinase-MB,and lactate dehydrogenase levels in diabetic *** also significantly reduced oxidative stress by increasing antioxidant enzymes,decreasing lipid peroxidation as well as restoring the levels of ascorbic acid and *** study demonstrated that FD-40 treatment improved cardiac structure in diabetic *** docking analysis revealed that phytocompounds from FD-40 had strong binding affinities with cardiac markers and oxidative ***(5TMS)demonstrated greater binding affinity with xanthine oxidase and lactate ***:FD-40 of Cleome viscosa methanolic extract exhibits significant cardioprotective effects in diabetic rats by regulating cardiac markers and reducing oxidative *** underlying mechanisms need to be elucidated in the future.

关键词： Cleome viscosa L. Cardioprotection cardiac markers Docking CK-MB GC-MS Diabetes

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The Association between Methylenetetrahydrofolate Reductase (MTHFR) Mutations and Serum Biomarkers of cardiac Health

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Open Journal of Preventive Medicine 2023年第4期13卷 87-107页

作者： Hari Krishnan Krishnamurthy Uma Maheshwari Balaguru Michelle Pereira Chithra Suresh Vasanth Jayaraman Karthik Krishna Qi Song Tianhao Wang Kang Bei John J. Rajasekaran Vibrant Sciences LLC. San Carlos CA USA Vibrant America LLC. San Carlos CA USA

Background: Homocysteine (tHcy) has emerged as a new risk factor for cardiovascular diseases (CVD) The Methylenetetrahydrofolate reductase (MTHFR) polymorphisms are seen to give rise to high levels of tHcy which can be a causative factor in the progression of CVD due to its thrombogenic effect. Serum cardiac biomarkers help in the diagnosis, prognosis, or surveillance of CVD. The present study evaluated the association of the two MTHFR mutations, rs1801133 and rs1801131 with 16 well-established serum cardiac markers. Additionally, the influence of age and gender on the association of the two MTHFR polymorphisms with serum cardiac marker levels was also investigated. Methods: The study was carried out on 1295 individuals who visited Vibrant America Clinical Lab for regular or suspected CVD check-ups. The serological markers and genomic variant analysis were carried out as per the standard laboratory protocol under CLIA. The association between serological markers and the rs1801133 and rs1801131 genetic variants with respect to age and gender was evaluated using a one-way ANNOVA test. Results: No significant association was observed in tHcy levels with respect to gender, however, plasma total tHcy levels were higher in males than females. tHcy levels increased with increasing age in the wild and heterozygous genotypes for the mutations, rs1801133 and rs1801131. Additionally, the serum cardiac markers, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Cholesterol (CHOL), Apolipoprotein A (APOA), Apolipoprotein B (APOB), N-terminal (NT)-pro hormone BNP (BNPNT), LDL calculated (LDLCAL), Small Density Low Density Lipoprotein (SDLDL), APOBAR, Oxidised Low Density Lipoprotein (OXLDL), Lipoprotein (A) (LPA), Triglycerides (TRIG), and Lipoprotein-Associated Phospholipase (Lp-PLA2) Test (PLAC) showed significant associations with respect to gender and age for rs1801133 and rs1801131 (P Conclusions: The present study reports the association of tHcy, HDL, LDL, CHOL,

关键词： Homocysteine MTHFR cardiac markers

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Assessing myocardial indices and inflammatory factors to determine anxiety and depression severity in patients with chronic heart failure

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World Journal of Psychiatry 2024年第1期14卷 53-62页

作者： Li Zhang Qiang Wang Hong-Sheng Cui Yuan-Yuan Luo Department of Cardiology Jingzhou HospitalYangtze UniversityJingzhou 434020Hubei ProvinceChina Department of Intensive Care Unit The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Patients with chronic heart failure(CHF)have a progressive disease that is associated with poor quality of life and high *** patients experience anxiety and depression(A&D)symptoms,which can further accelerate disease *** hypothesized that indicators of myocardial function and inflammatory stress may reflect the severity of A&D symptoms in patients with *** in these biomarkers could potentially predict whether A&D symptoms will deteriorate further in these *** To measure changes in cardiac and inflammatory markers in patients with CHF to determine A&D severity and predict *** We retrospectively analyzed 233 patients with CHF treated at the Jingzhou Hospital,Yangtze University between 2018-2022 and grouped them according to Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)*** compared clinical data in the no-A&D,mild-A&D,moderate-A&D,and severe-A&D groups,the SAS and SDS scores with the New York Heart Association(NYHA)functional classification,and cardiac markers and inflammatory factors between the no/mild-A&D and moderate/severe-A&D *** analysis was performed on the markers with P0.05).In addition,we found that higher NYHA classes were associated with higher the SAS and SDS scores(P<0.05).Regression analysis showed that LVEF,NTproBNP,and IL-6 were independent risk factors for A&D severity(P<0.05).Among them,NT-pr

关键词： Chronic heart failure Anxiety Depression cardiac markers Inflammatory factors Prediction

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