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Relationship between trefoil factor 1 expression and gastric mucosa injuries and gastric cancer

World Journal of Gastroenterology 2005年第17期11卷 2674-2677页

作者： Jian-LinRen Jin-YanLuo Ya-PiLu LinWang Hua-XiuShi DepartmentofGastroenterology TheSecondHospitalXianJiaotongUniversityXi'an710004ShaanxiProvinceChina DepartmentofGastroenterology TheSecondHospitalXianJiaotongUniversityXi'an710004ShaanxiProvinceChina//DepartmentofGastroenterologyZhongshanHospitalXiamenUniversityXiamen361004FujianProvinceChina

AIM:To determine whether trefoil factor 1 (TFF1) is associated with mucosa healing and carcinoma suppression, we assess the expression of trefoil factor 1 in normal and pathologic gastric mucosa. METHODS: TFF1 in normal and pathologic gastric mucosa was assessed by immunohistochemical method, and the average positive A was estimated by Motic Images Advanced 3.0 software. RESULTS: Increased TFF1 was detected in gastritis, gastric ulcer and duodenal ulcer compared with normal mucosa. The same result could be seen in multiple and compound ulcer compared with simple ulcer. There was no significant difference between gastric ulcer and duodenal ulcer, gastritis and simple ulcer respectively. Increased TFF1 was detected in the peripheral mucosa of the gastric adenocarcinoma compared with normal mucosa. The expression of TFF1 in gastric adenocarcinoma was related to the differentiation of adenocarcinoma. The lower the differentiation of adenocarcinoma, the weaker the expression of TFF1. There was no TFF1 expressed in low-differentiated adenocarcinoma. The expression of TFF1 in middle and highly differentiated adenocarcinoma was a little lower than that in normal mucosa. But there was no significant difference. No TFF1 was assessed in esophageal squamous carcinoma and peripheral tissue. There was no significant difference between male and female. CONCLUSION: The expression of TFF1 was higher in gastritis and peptic ulcer than that in normal mucosa, and was also higher in multiple and compound ulcer than in simple ulcer. It seems that TFF1 plays a role in gastric mucosa protection and epithelial restitution. Increased expression of TFF1 in peripheral tissue suggests that TFF1 is associated with mechanism of carcinoma suppression and differentiation. Decreased expression of TFF1 in carcinoma and its relativity to the differentiation suggests that TFF1 is related to gland and cell destruction of carcinoma.

关键词： Trefoil factor Gastric mucosa protection Epithelial restitution carcinoma suppression

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Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues

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World Journal of Gastroenterology 2006年第45期12卷 7361-7364页

作者： Jian-Lin Ren Jin-Yan Luo Ya-Pi Lu Lin Wang Hua-Xiu Shi Department of Gastroenterology The Second Hospital Xian Jiaotong University Xi'an 710004 Shaanxi Province China Department of Gastroenterology Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

AIM： To study the molecular forms of trefoil factor 1 （TFF1） in normal gastric mucosa and its expression in normal and abnormal gastric tissues （gastric carcinoma, atypical hyperplasia and intestinalized gastric mucosa） and the role of TFF1 in the carcinogenesis and progression of gastric carcinoma and its molecular biological mechanism underlying gastric mucosa protection. METHODS： The molecular forms of TFF1 in normal gastric mucosa were observed by Western blot. The expression of TFF1 in normal and abnormal gastric tissues （gastric carcinoma, atypical hyperplasia and intestinalized gastric mucosa） was also assayed by immunohistochemical method. The average positive AO was estimated by Motic Images Advanced 3.0 software. RESULTS： Three patterns of TFF1 were found in normal gastric mucosa： monomer, dimmer, and TFF1 compound whose molecular weight is about 21 kDa. The concentration of TFF1 compound was the highest among these three patterns. TFF1 was expressed mainly in epithelial cytoplasm of the mucosa in gastric body and antrum, especially around the nuclei. The closer the TFF1 to the lumen, the higher the expression of TFF1, The expression of TFF1 in peripheral tissue of gastric carcinoma （0.51 ± 0.07） was higher than that in normal gastric mucosa （0.44 ± 0.06, P 〈 0.001）. The expression of TFF1 in gastric adenocarcinoma was positively related to the differentiation of adenocarcinoma. The lower the differentiation of adenocarcinoma was, the weaker the expression of TFF1. No TFF1 was expressed in poorlydifferentiated adenocarcinoma. The expression of TFF1 in moderately-well differentiated adenocarcinoma （0.45 ± 0.07） was a little lower than that in normal mucosa （P 〉 0.05）. The expression of TFF1 in gastric mucosa with atypical hyperplasia （0.57 ± 0.03） was significantly higher than that in normal gastric mucosa （P 〈 0.001）. No TFF1 was expressed in intestinalized gastric mucosa. There was no statistically significant difference between the expressions of TFF

关键词： Trefoil factor 1, Gastric mucosa protection carcinoma suppression

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The relationship between trefoil factor 1 expression and gastric mucosa injuries & gastric cancer

The relationship between trefoil factor 1 expression and gas...

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中华医学会消化病学分会——2005年全国胃肠激素学术研讨会

作者： Ren Jian-lin, Lu Ya-pi ,wang lin,shi huaxiu, Department of Gastroenterology, the zhongshan Hospital,Xiamen University, Xiamen 361004, China

AIM: To determine whether TFFl is associated with mucosa healing and carcinoma suppression, we assessthe expression of trefoil factor 1 in normal and pathologic gastric mucosa..Methods: Trefoil factor 1 in normal and pathologic gastric mucosa was assessed by immunohistochemicalmethod, and the average positive OD was estimated by Motic Images Advanced 3.0 ***: Increased TFFl was detected in gastritis, gastric ulcer and duodenal ulcer compared with normalmucosa. The same result could be seen in multiple and compound ulcer compared with simple ulcer. Therewas no significant difference between gastric ulcer and duodenal ulcer, gastritis and simple ulcerrespectively. Increased TFFl was detected in the peripheral mucosa of the gastric adenocarcinomacompared with normal mucosa. The expression of TFFl in gastric adenocarcinoma was related to thedifferentiation of adenocarcinoma. The lower adenocarcinoma differentiated, the weaker TFFl *** was no TFFl expressed in low differentiated adenocarcinoma. The expression of TFFl in middle andhigh differentiated adenocarcinoma was a little lower than that in normal mucosa. But there was nosignificant difference. No TFFl was assessed in esophageal squamous carcinoma and peripheral *** was no significant difference between male and ***: The expression of TFFl was higher in gastritis and peptic ulcer than that in normal mucosa,and was also higher in multiple and compound ulcer than that in simple ulcer. It seems that TFFl plays arole in gastric mucosa protection and epithelial restitution. Increased expression of TFFl in peripheraltissue suggests TFFl is associated with mechanism of carcinoma suppression and *** expression of TFFl in carcinoma and its relativity to the differentiation suggests TFFl is relatedto gland and cell destruction of carcinoma.

关键词： Trefoil factor TFF1 Gastric mucosa protection Epithelial restitution carcinoma suppression

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