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Evidence based tools to improve efficiency of currently administered oncotherapies for tumors of the hepatopancreatobiliary system

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1109-1120页

作者： Zoltan Herold A Marcell Szasz Magdolna Dank Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest H-1083Hungary

Hepatopancreatobiliary tumors are challenging to treat,and the advanced or metastatic forms have a very low 5-year survival *** drug combinations have been tested,and new therapeutic approaches have been introduced in the last decades,including radiofrequency and heat based *** is the artificial heating of tumors by various biophysical methods that may possess immunostimulant,tumoricidal,and chemoradiotherapy sensitizer *** whole-body and regional hyperthermia studies have been conducted since the 1980s after the introduction of deep-seated tumor hyperthermia *** of the effects of hyperthermia in hepatocellular and pancreatic cancer are known from several *** in biliary cancers is a less investigated *** local and overall responses to treatment,increased progression-free and overall survival,and improved laboratory and quality-of-life results are associated with hyperthermia in all three tumor *** the evolution of chemotherapeutic agents and the introduction of newer techniques,the combination of adjuvant hyperthermia with those therapies is advantageous and has not been associated with an increase in alarming adverse ***,despite the many positive effects of hyperthermia,its use is still only known at the experimental level,and its concomitant utilization in routine cancer treatment is not certain because of the lack of thorough clinical studies.

关键词： Hyperthermia induced carcinoma hepatocellular Cholangiocarcinoma Gallbladder neoplasms Pancreatic neoplasms

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