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Direct costs of carcinoid syndrome diarrhea among adults in the United States

World Journal of Gastroenterology 2019年第47期25卷 6857-6865页

作者： Arvind Dasari Vijay N Joish Raul Perez-Olle Samyukta Dharba Kavitha Balaji Daniel M Halperin Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Lexicon Pharmaceuticals Inc.The WoodlandsTX 77381United States

BACKGROUND The burden of carcinoid syndrome(CS)among patients with neuroendocrine tumors is substantial and has been shown to result in increased healthcare resource use and *** incremental burden of CS diarrhea(CSD)is less well understood,particularly among working age adults who make up a large proportion of the population of patients with *** To estimate the direct medical costs of CSD to a self-insured employer in the United *** CS patients with and without CSD were identified in the IBM®MarketScan®Database,including the Medicare Supplemental Coordination of Benefits *** patients had≥1 medical claim for CS with continuous health plan enrollment for≥12 mo prior to their first CS diagnosis and for≥30 d after,no claims for acromegaly,and no clinical trial participation during the study period(2014-2016).Baseline demographic and clinical characteristics,including comorbidities and treatment,were analyzed using descriptive *** of healthcare resource use and costs were compared between patients with and without CSD,including Emergency Department(ED)visits,hospital admissions and length of stay,physician office visits,outpatient services,and prescription claims,using univariate and multivariate analyses to evaluate associations of CSD with healthcare resource use and costs,controlling for baseline *** Overall,6855 patients with CS were identified of which 4,043 were eligible for the analysis(1352 with CSD,2691 with CS only).Baseline demographic and clinical characteristics were similar between groups with the exception of age,underlying tumor type,and health insurance *** with CSD were older,had more comorbidities,and received more somatostatin analog therapy at *** with CSD required greater use of healthcare resources and incurred higher costs than their peers without CSD,including hospitalizations(44%vs 25%)and ED visits(55%vs 31%).The total adjusted annual healthcare costs

关键词： carcinoid syndrome carcinoid syndrome diarrhea Healthcare costs Neuroendocrine tumors

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