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Development and evaluation of Panax notoginseng saponins contained in an in situ pHtriggered gelling system for sustained ocular posterior segment drug delivery

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Acupuncture and Herbal Medicine 2021年第2期1卷 107-121页

作者： Peng Lu Renxing Wang Yue Xing Yanquan Gao Qingqing Zhang Bin Xing Ying Zhang Changxiang Yu Xinfu Cai Qiang Shang Dereje Kebebe Jiaxin Pi Zhidong Liu State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjinChina Department of pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhouChina Sichuan Guangda Pharmaceutical Co.LTD PengzhouChina Sichuan Engineering Research Center of Antiviral Traditional Chinese Medicine Industrialization PengzhouChina School of Pharmacy Institute of HealthJimma UniversityJimmaEthiopia

Objective:This study aimed to lay the foundation for the research on Panax notoginseng saponins(PNS)in pH-sensitive in situ gel and the development and improvement of related ***:We used carbopol■940,a commonly used pH-sensitive polymer,and the thickener hydroxypropyl methylcellulose(HPMC E4M)as an ophthalmic gel matrix to prepare an ophthalmic in situ gel of *** addition,formula optimization was performed by assessing gelling capability with the results of in vitro release *** vitro(corneal permeation,rheological,and stability)and in vivo(ocular irritation and preliminary pharmacokinetics in the vitreous)studies were also ***:The results demonstrated that the in situ gelling systems containing PNS showed a sustained release of the drug,making it an ideal ocular delivery system for improving posterior ocular ***:This study lays the foundation for the research of PNS contained in an in situ pH-triggered gel as well as the development and improvement of related *** concurrently traditional Chinese medicine with a contemporary in situ gelling approach to provide new directions for the treatment of posterior ocular diseases such as diabetic retinopathy.

关键词： carbopol■940 Hydroxypropyl methylcellulose Panax notoginseng saponins pH-triggered gelling system Sustained release drug delivery

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