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Carcinoembryonic antigen,carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1475-1485页

作者： Ran Wang Chun-Lei Zuo Rui Zhang Li-Mei Zhu Department of Medical Laboratory The First People’s Hospital of LianyungangLianyungang 222002Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignant tumor of the digestive system with a high degree of *** usually develops insidiously without any specific symptoms in the early *** one of the diseases caused by abnormal gene changes,GC has abnormal expression of various oncogenes and products during its *** markers such as carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)and carbohydrate antigen 724(CA724)are not expressed or lowly expressed in normal people,but significantly increased after *** the changes in the levels of tumor markers such as CEA,CA199 and CA724 is conducive to early diagnosis and evaluation of the occurrence of some solid *** To investigate the expression of CEA,CA199 and CA724 in GC and their correlation with clinical features,hoping to provide more effective markers for the early preventive diagnosis of *** Of 87 patients with GC admitted to our hospital from September 2020 to December 2021 were included in the GC group,and another 80 healthy people who came to our hospital for physical examination with normal results during the same period were selected as the control *** serum CEA,CA199,and CA724 levels were compared between the two groups,and the serum CEA,CA199,and CA724 levels were compared in patients with GC at different TNM stages,and the differences in the positive rates of CEA,CA199,and CA724 alone and in combination in detecting TNM stages of GC and GC were *** addition,the relationship between the levels of tumor markers CEA,CA199 and CA724 and the clinicopathological characteristics of GC patients was also *** relationship between the serum levels of CEA,CA199 and CA724 and the survival period of GC patients was analyzed by *** The serum levels of CEA,CA199 and CA724 in GC group were significantly higher than those in control group(P724 expression levels

关键词： Carcinoembryonic antigen carbohydrate antigen 199 carbohydrate antigen 724 Gastric cancer TNM stage Clinicopathologic

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