检索结果-南通市图书馆

Using Network Pharmacology to Explore the Mechanism of capsicum in Treating Type 2 Diabetes Mellitus

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Medicinal Plant 2023年第4期14卷 27-30,45页

作者： Yunfeng BAI Yuxin HANG Ning XU Jinglin LIU Liang XU College of Chemistry and Materials Science Inner Mongolia Minzu University/Key Laboratory of Natural Product Chemistry and Functional Molecular Synthesis of Inner Mongolia Autonomous RegionTongliao 028000China

[Objectives] The paper was to explore the mechanism of capsicum ( capsicum annuum L.) in treating type 2 diabetes mellitus (T2DM) and search for new targets. [Methods] The active ingredients of capsicum were queried from TCMSP database to obtain the corresponding target proteins. The related targets of T2DM were screened from GeneCards database, and the target intersection of active ingredients of capsicum and diabetes mellitus was obtained via Venny software. The protein-protein interaction (PPI) network of the compounds was constructed using STRING database, and the GO bio-function and KEGG pathway enrichment were further analyzed using Metascape database. [Results] Through TCMSP database query and conditional screening, 14 candidate active molecules, 93 potential targets and 225 related pathways were obtained. [Conclusions] The results of GO and KEGG enrichment analysis show that the main active ingredients of capsicum play a role in the treatment of T2DM by regulating cancer pathways, chemical carcinogenesis—receptor activation, proteoglycans in cancer, and prostate cancer pathways, which will provide an important theoretical basis for subsequent research.

关键词： Network pharmacology capsicum Type 2 diabetes mellitus Mechanism of action

Genetic Variability in Germplasm Accessions of capsicum annuumL

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2011年第5期2卷 629-635页

作者： Shrilekha Misra Raj Kishori Lal Mahendra Pandurang Darokar Suman Preet Singh Khanuja 不详

capsicum annuum is the most widely cultivated species of peppers (chilies) in the world. For culinary purposes, its fruits are used for pungency (capsaicin) and also color (capsanthin). Capsaicin is also used for medicinal purposes particularly in anti-inflammatory formulations. Genetic divergence among 38 accessions collected from diverse locations in India (28 from Uttar Pradesh, 5 from Assam, 3 from Maharashtra and 2 from Uttaranchal), was estimated from the data pooled over 3 consecutive years for 15 morphological, growth and chemotypic characters that included days to first and second flowering, fruit onset, plant height, primary, secondary and tertiary branches, leaf surface area, fruit length and diameter, fruit surface area, fresh and dry fruit weight, capsaicin and capsanthin content. Based on this characterization the plants could be grouped into 7 clusters wherein substantial diversity among accessions was indicated by the wide range of D2 values (752.901 - 1918683.00). Accessions with distinct identity were marked, which are likely to be quite suitable for breeding through hybridization combining desirable traits. The accessions labeled number 38, 27, 26, 14 and 24 to high capsaicin content (%);35, 23, 3, 16, 29 and 11 for high capsanthin content (%) and 26 and 27 for dual purpose had characteristics desirable. Above accessions could be utilized in hybridization programme for C. annuum crop improvement.

关键词： Genetic Diversity capsicum Annuum Capsaicin and Capsanthin Content Recombination Breeding Geographical Distribution

Evaluation of the Anti-Proliferative Effects of a Green Tea and capsicumPowder Extract in Cancer Cell Lines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2020年第2期11卷 44-54页

作者： Eleana Hatzidaki Maria Papadimitriou Ioannis Papasotiriou Research Genetic Cancer Centre SA Florina Greece Research Genetic Cancer Centre International GmbH Zug Switzerland

In recent years the use of natural supplements in order to prevent, treat or delay recurrence of cancer or reduce chemotherapy toxicity has attracted much?attention. One such supplement is Capsol-T which consists of de-caffeinated green tea and chili pepper extracts. The aim of the study was the evaluation of Capsol-T effect on the proliferation of various cancer cell lines representing different cancer types. Cell lines that were used in the study were: DU145, LNCap,?MCF7, HCT116 and MOR. The effect of various concentrations and incubation times of Capsol-T on cell viability was determined using the MTT method. The results do not show a common anti-proliferative pattern in all cancer cells.?In some cell lines and certain concentrations cell growth was significantly decreased at 24 hr which became more evident at 48?hr. The role of capsicum?powder in cancer is unclear since both cancer cell proliferation and growth arrest have been demonstrated. Green tea on the other hand was found to decrease certain drugs’ bioavailability. Our results suggest that an anti-proliferative?effect in certain types of cancer should not be generalized to other types as well.?Different concentrations also affect the net result often having opposite effects. Overall, caution should be taken when using natural supplements for their anti-cancer effects.

关键词： Proliferation Cancer Green Tea capsicum Powder

Accession ×Treatment Interaction, Variability and Correlation Studies of Pepper (capsicumspp.) under the Influence of Arbuscular Mycorrhiza Fungus (Glomus clarum) and Cow Dung

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2014年第5期5卷 683-690页

作者： Odunayo Joseph Olawuyi Segun Gbolagade Jonathan Fikayo Ezekiel Babatunde Busayo Joshua Babalola Ola Oluwa Simon Yaya James Oludare Agbolade Daniel Ayandiran Aina Chike Joseph Egun Department of Agronomy College of Agriculture Osun State Uni-versity Ejigbo Campus Ejigbo Nigeria Department of Biosciences and Biotechnology Babcock University Lagos Nigeria Department of Plant Sciences and Biotechnology Federal University Oye-Ekiti Oye-Ekiti Nigeria Department of Statistics University of Ibadan Ibadan Nigeria Genetics & Molecular Biology Unit Department of Botany University of Ibadan Ibadan Nigeria Mycology & Biotechnology Unit University of Ibadan Ibadan Nigeria

The field experiment was conducted in the Department of Botany, University of Ibadan, Nigeria between September to December 2012. Four accessions of pepper (capsicum spp.), obtained from Moor plantation in Ibadan and LUTH (Lagos University Teaching Hospital) vegetable garden, Idi-Araba Lagos were evaluated to investigate the morpho-agronomic variability and interaction of accession × treatment × days after transplant in treatment combinations of arbuscular mycorrhizal fungus (Glomus clarum) and cowdung. The experiment was a 4 × 4 factorial arrangement laid out in a randomized complete block design with three replications. The combined analysis of variance showed significant accession, treatment, days after transplant, and accession × treatment interactive effect for most of the growth characters at P 0.01 and P 0.05. The result also showed significant difference in yield related traits of fruits for pepper accessions. The number of leaves per plant was significant and positively associated with plant height (r = 0.516;P 0.05), and highly significant and positively correlated with the number of branches (r = 0.836;P 0.01), but negative and non-significantly related with stem girth. Glomus clarum treated plants responded significantly with higher growth and yield. It suggested that G. clarum treatment had higher potential in influencing crop yield compared to cowdung and untreated plants. This study further explored the relationship between G.

关键词： capsicum Glomus clarum Cowdung Variability Yield

Molecular Diversity Analysis of Some Chilli (capsicumspp.) Genotypes Using SSR Markers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2018年第3期9卷 368-379页

作者： Afsana Sharmin Md. Ekramul Hoque Md. Masudul Haque Fahima Khatun Department of Biotechnology Sher-e-Bangla Agricultural University Dhaka Bangladesh Regional Spices Research Centre Bangladesh Agricultural Research Institute (BARI) Dhaka Bangladesh

Chilli belongs to the genus capsicum which possesses enormous wealth of genetic diversity. Extent of genetic diversity determines the success level of crop improvement programme. Simple sequence repeats (SSRs) are the most widely used marker system for molecular diversity analysis especially in cultivated species. The aim of our present study was to assess the molecular genetic diversity of 20 local chilli genotypes of Bangladesh using SSR markers. Genomic DNA was extracted from young leaves and PCR reactions were performed. Eleven SSR primers were used in PCR amplification. Total 10 alleles were detected for the five polymorphic SSR loci, with a mean of 2.00 alleles per primer. Gene diversity ranged from 0.333 to 1.00 with an average of 0.567. Polymorphic Information Content (PIC) values of the SSR primers ranged from 0.255 to 0.500 with an average value of 0.371. The similarity index matrix ranged from 0.00 to 1.000. It was highest in several germplasms viz. Pop-2 vs Pop-18;Pop-3 vs Pop-5 vs Pop-19 vs Pop-20 and the lowest in the germplasm Pop-8 vs Pop-18. Dendrogram based on Nei’s genetic distance using Unweighted Pair Group Method of Arithmetic Means (UPGMA) indicated the segregation of 20 chilli genotypes into two main clusters. The SSR markers showed genetic variability in the studied pepper genotypes and they are powerful tools for estimating molecular diversity of chilli. The findings of the present study have potential applications in future breeding programme for the genetic improvement of chilli.

关键词： capsicum Molecular Diversity Genotypes SSR Markers Polymorphism

Effect of Instant Controlled Pressure Drop Process Coupled to Drying and Freezing on Antioxidant Activity of Green “Poblano” Pepper (capsicum annuumL.)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2013年第3期4卷 321-334页

作者： Carmen Téllez-Pérez Anaberta Cardador-Martínez Sabah Mounir José Gerardo Montejano-Gaitán Vaclav Sobolik Karim Allaf Department of Food Science Faculty of Agriculture Zagazig University Zagazig Egypt LaSIE FRE 3474 CNRS Laboratory Engineering Science for Environment University of La Rochelle La Rochelle France. Tecnológico de Monterrey-Escuela en Ingeniería Biotecnología y Agronomía Querétaro México

Different food operations have been intensified through assisting them by instant controlled pressure drop DIC treatment. Such processes should be defined in order to preserve the main nutritional and sensorial contents of the raw material. The present paper is dedicated to study the evolution of the main bioactive compounds (total phenolics and flavonoids) and functional properties such as the antioxidant activity of processed samples in the case of Green “Poblano” Pepper (capsicum annuum L.). Results issued from DIC-assisted hot air drying, and DIC-assisted freezing, allowed to identifying the impact of DIC studied operating parameters, which were the saturated steam pressure and the processing time, and the best DIC treatment correlated with the considered operation.

关键词： Instant Controlled Pressure Drop capsicum Phenols Flavonoids Antioxidant Activity Drying Freezing

A Comt1 Loss of Function Mutation Is Insufficient for Loss of Pungency in capsicum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2015年第8期6卷 1243-1255页

作者： Sota Koeda Kosuke Sato Yuri Tanaka Rihito Takisawa Akira Kitajima Faculty of Agriculture Kinki University Nara Japan Experimental Farm Graduate School of Agriculture Kyoto University Osaka Japan

The participation of O-methyltransferase (COMT) in phenylpropanoid-mediated capsaicinoid biosynthesis has long been proposed. Ferulic acid, a phenylpropanoid intermediate, is a precursor of capsaicinoid biosynthesis and is produced from caffeic acid by the action of COMT. As previously reported that silencing Comt expression caused a drastic decrease in capsaicinoid accumulation, it was presumed that a Comt loss-of-function mutation would cause loss of pungency in capsicum. This hypothesis was tested by cloning Comt1 and Comt2 from the placenta tissue of the pungent cultivar Habanero. The phylogenetic analysis and comparison of critical amino-acid residues for enzyme function showed that the two COMTs had high similarity with the COMTs of other plant species. Moreover, as the two Comts were both expressed in placenta tissue and expressed prior to the accumulation of capsaicinoids, the two genes could be candidates for capsaicinoid biosynthesis. Second, Comt1 loss-of-function mutants were screened from the germplasm. A truncated Comt1 transcript was expressed in non-pungent pepper No.3341 caused by deletion of the genomic region. The predicted No.3341 COMT1 lacked His-265, which was absolutely necessary for enzymatic activity. Contrary to our expectations, the Comt1 mutation was not related to non-pungency of No.3341, as the deletion of Comt1 did not co-segregate with non-pungency in the F2 population obtained from crossing No.3341 with Habanero. This result was confirmed by screening several pungent accessions harboring the same Comt1 deletion mutation. Although the participation of COMT in phenylpropanoid-mediated capsaicinoid biosynthesis has long been proposed, our present study shows that Comt1 can not be a target for controlling fruit pungency.

关键词： Capsaicinoids capsicum Comt Pepper Phenylpropanoid Pathway Pungency

Influence of Red Pepper (capsicum annuum) Addition on Bioenergy Production in Microbial Fuel Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sustainable Bioenergy Systems 2019年第4期9卷 179-188页

作者： Sohyun Chang Min Jae Shin Yujin Kim Sung Jun Jang Seog In Moon Seoyeon Jeong Richard Shim Fengjun Shen Sara Kang Paul S. Chung School of Arts & Sciences Johns Hopkins University Baltimore MD USA Fuzbien Technology Institute Rockville MD USA Youth with Talents Fairfax VA USA

The current study was performed to evaluate the beneficial effect in the power output of microbial fuel cells (MFCs) through supplementation of dried red pepper (capsicum annuum) powder into the anodic chamber. Mediator-less H-type MFCs were set up where the anode chamber contained rumen microorganisms as inocula on cellulose (Avicel) and the cathode chamber of phosphate buffered saline (pH 7.4), both separated by cation exchange membrane. Electrical power generation in MFC was monitored daily over a 10-day period and the accumulated amounts and components of gaseous byproducts were measured at the end of 10 d operation of MFC. For both groups of MFCs with red pepper and the control, the head space gases collected were methane and CO2, and its volume and composition were similar between treatments. Methane and CO2 produced for 10 d operation were 210.7 and 106.5 mL, respectively, in MFC. The addition of red pepper powder caused an average power density to increase from 24.0 mW/m2 to 39.6 mW/m2 (P 2 for control and bellflower, respectively. This study provides the strong evidence that red pepper (capsicum annuum) supplementation might modify the anaerobic fermentation characteristics of rumen microorganisms in anode chamber and improve the cellulosic bioenergy production in MFC.

关键词： MFC capsicum annuum Bioenergy Production

Pan-plastome approach empowers the assessment of genetic variation in cultivated capsicum species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2019年第1期6卷 456-470页

作者： Mahmoud Magdy Lijun Ou Huiyang Yu Rong Chen Yuhong Zhou Heba Hassan Bihong Feng Nathan Taitano Esther van der Knaap Xuexiao Zou Feng Li Bo Ouyang Key Laboratory of Horticultural Plant Biology(Ministry of Education) Huazhong Agricultural University430070 WuhanChina Genetics Department Faculty of AgricultureAin Shams UniversityCairo 11241Egypt College of Horticulture and Landscape Hunan Agricultural University410128 ChangshaChina College of Agriculture Guangxi University530004 NanningChina Department of Horticulture College of Agriculture&Environmental SciencesUniversity of GeorgiaAthensGA 30602USA

Pepper species(capsicum spp.)are widely used as food,spice,decoration,and *** the recent old-world culinary impact,more than 50 commercially recognized pod types have been recorded worldwide from three taxonomic complexes(A,B,and P).The current study aimed to apply a pan-plastome approach to resolve the plastomic boundaries among those complexes and identify effective loci for the taxonomical resolution and molecular identification of the studied species/***-resolution pan-plastomes of five species and two varieties were assembled and compared from 321 *** and network analyses clarified the taxonomic position of the studied species/varieties and revealed a pronounced number of accessions to be the rare and endemic species,***,that were mistakenly labeled as *** *** among ***,some NCBIdeposited plastomes were clustered differently from their *** rpl23-trnI intergenic spacer contained a 44 bp tandem repeat that,in addition to other InDels,was capable of discriminating the investigated capsicum species/*** rps16-trnQ/rbcL-accD/ycf3-trnS gene set was determined to be sufficiently polymorphic to retrieve the complete phyloplastomic signal among the studied capsicum *** pan-plastome approach was shown to be useful in resolving the taxonomical complexes,settling the incomplete lineage sorting conflict and developing a molecular marker set for capsicum ***.

关键词： capsicum approach