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第二届全国发育生物学大会

作者： Xiaojie Yang Zongbin Cui Institute of Hydrobiology Chinese Academy of Sciecnes

Background:Nucleoporin p62(Nup62)is localized in the central channel of nuclear pore complexes(NPCs)and participates the control of nuclear pore permeability and nucleocytolasmic ***,develop-mental roles of Nup62 in vertebrates remain largely ***:Zebrafish Nup62-like protein(Nup621)is an orthologue of mammalian *** nup621 gene is maternally expressed,but its transcripts are ubiquitously distributed during early embryogenesis and en-riched in the head,pharyngal and intestine of developing *** of wnt/p-catenin pathway positively modulates the nup621 transcription,while Bmp signaling acts downstream of wnt/p-catenin sig-naling to negatively regulate the *** of nup621 dorsalized embryos and en-hanced gastrula convergence and extension(CE)***,knockdown of Nup621 led to vent-ralized embryos,an impediment to CE movements and defects in specification of midline organ ***,Nup621 acts as an activator of wnt/p-catenin signaling through interaction with and nuclear import of P-catenin-1/2 in ***:Nup621 regulates dorsoventral patterning,gastrula CE movements and proper specification of midline organ precursors through mediating the nuclear import of p-catenins in zebrafish.

关键词： Nucleoporin 62-like canonical wnt signaling Dorsoventral patterning

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The human and mouse sex-determining SRY genes repress the Rspo1/β-catenin signaling

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Journal of Genetics and Genomics 2009年第4期36卷 193-202页

作者： Yun-Fai Chris Lau Division of Cell and Developmental Genetics Department of Medicine VA Medical Center University of CaliforniaSan Francisco CA 94121 USA

The sex-determining region Y （SRY） is the gene on the Y chromosome responsible for switching on male sex determination during mammalian embryogenesis. In its absence, ovaries develop in the embryo. Hence, ovarian determination and differentiation is considered to be a default, or passive, developmental pathway. Recently this classical paradigm of sex determination has been challenged with the discovery of the R-spondin 1 （RSPO1） as an active ovarian determinant. Mutations of RSPO1 cause a female-to-male sex reversal. RSPO1 synergizes with wnt4 in activating an ovarian development in the bipotential gonad via the canonical wnt signaling. Early studies showed that SRY represses such wnt signaling, but also generated discrepancies on whether only mouse Sry is capable of inhibiting such wnt signaling and whether both human and mouse SRY proteins are able to interact with β-catenin, the intracellular messenger responsible for executing the wnt signals. Our studies show that both human SRY and mouse Sry are capable of repressing the Rspol/wnt/β-catenin signaling. However, the repression activities vary among different SRY/Sry proteins and paradoxically related to the presence and/or size of an acidic/glutamine-rich domain. The HMG box of human SRY could bind directly to β-catenin while the mouse Sry binds to β-catenin via its HMG box and glutamine-rich domain. The results clarify some of the initial discrepancies, and raise the possibility that SRY interacts with β-catenin in the nucleus and represses the transcriptional activation of the Rspol/wnt target genes involved in ovarian determination, thereby switching on testis determination.

关键词： SRY sex determination R-spondin 1 canonical wnt signaling β-catenin protein interaction

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