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Role of cannabinoids and the endocannabinoid system in modulation of diabetic cardiomyopathy

World Journal of Diabetes 2022年第5期13卷 387-407页

作者： Mona F El-Azab Ahmed E Wakiel Yossef K Nafea Mahmoud E Youssef Department of Pharmacology and Toxicology Faculty of PharmacySuez Canal UniversityIsmailia 41522Egypt Program of Biochemistry McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Pharmacology and Biochemistry Delta University for Science and TechnologyMansoura 35511New CairoEgypt

Diabetic complications,chiefly seen in long-term situations,are persistently deleterious to a large extent,requiring multi-factorial risk reduction strategies beyond glycemic control.Diabetic cardiomyopathy is one of the most common deleterious diabetic complications,being the leading cause of mortality among diabetic patients.The mechanisms of diabetic cardiomyopathy are multi-factorial,involving increased oxidative stress,accumulation of advanced glycation end products(AGEs),activation of various pro-inflammatory and cell death signaling pathways,and changes in the composition of extracellular matrix with enhanced cardiac fibrosis.The novel lipid signaling system,the endocannabinoid system,has been implicated in the pathogenesis of diabetes and its complications through its two main receptors:cannabinoid receptor type 1 and cannabinoid receptor type 2,alongside other components.However,the role of the endocannabinoid system in diabetic cardiomyopathy has not been fully investigated.This review aims to elucidate the possible mechanisms through which cannabinoids and the endocannabinoid system could interact with the pathogenesis and the development of diabetic cardiomyopathy.These mechanisms include oxidative/nitrative stress,inflammation,accumulation of AGEs,cardiac remodeling,and autophagy.A better understanding of the role of cannabinoids and the endocannabinoid system in diabetic cardiomyopathy may provide novel strategies to manipulate such a serious diabetic complication.

关键词： Δ9-tetrahydrocannabinol Autophagy cannabinoid receptors Diabetic cardiomyopathy Endocannabinoid system Inflammation

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Endocannabinoid immune and vascular signaling

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Acta Pharmacologica Sinica 2000年第12期21卷 16-26页

作者： George B STEFANO Beth Israel Deaconess Medical Center Boston MA 02215 NY 11568 and Mind Body Medical Institute Neuroscience Research Institute P O Box 210 State University of New York at Old Westbury USA

HISTORY Hemp has been cultivated for 7000 to 8000 yearsc. The Sumerian/Babylonian term for cannabis hemp is K (a)N(a)B(a), and it is one of the longest surviving root words in Indo-Semitic-European language. In 2700 BC, Shen Nung, a contributor to early Chinese medicine, mentions cannabis in the pharmacopoeia. Around 500 BC Zoroaster, a Persian prophet, in the Zend-Avesta, listing 10 000 medicinal plants, includes hemp. In the first century AD the Chinese begin making paper from hemp as an inexpensive means of preserving information. In 800 AD the Islamic prophet Mohammed allows cannabis use. In 1100, Moslems use cannabis to start

关键词： anandamide nitric oxide 2-arachi-donyl-glyceral cannabinoid receptors vascular endothe-lium hemp immune cells

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Cannabinomimetric Lipids:From Natural Extract to Artificial Synthesis

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Natural Products and Bioprospecting 2018年第1期8卷 1-21页

作者： Ya-Ru Gao Yong-Qiang Wang Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education Department of Chemistry&Materials ScienceNorthwest UniversityXi’an 710069People’s Republic of China

Endocannabinoid system is related with various physiological and cognitive processes including fertility,pregnancy,during pre-and postnatal development,pain-sensation,mood,appetite,and memory.In the latest decades,an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB1 and CB2.Anandamide was the first reported endogenous metabolite,which adjusted the release of some neurotransmitters through binding to the CB1 or CB2 receptors.Then a series of cannabinomimetric lipids were extracted from marine organisms,which possessed similar structure with anandamide.This review will provide a short account about cannabi-nomimetric lipids for their extraction and synthesis.

关键词： Endocannabinoid cannabinoid receptors Cannabinomimetric lipids

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Kigelia africana Fruit:Constituents,Bioactivity, and Reflection on Composition Disparities

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World Journal of Traditional Chinese Medicine 2017年第4期3卷 1-6页

作者： Ahmed Galal Osman Zulfiqar Ali Amar G.Chittiboyina lkhlas A.Khan National Center for Natural Products Research University of Mississippi Department of BioMolecular Sciences Division of Pharmacognosy School of PharmacyUniversity of Mississippi

Objective: Kigelia africana, a tropical tree, which has long been used in African traditional medicine. The objective of the current study has been identifying the constituents of K. africana and verifying its utilities in traditional medicine. Materials and Methods: The methanol extract of K. africana fruits was subjected to chromatographic fractionation utilizing different techniques. The methanol extract together with the isolated compounds were tested for their bioactivities in a series of cell-based assays. Results: The current work led to isolation and characterization of nine constituents including iridoid glycosides, phenylpropanoid derivatives, and a eucommiol derivative. The hexanes extract caused inhibition of the opportunistic yeast; Cryptococcus neoformans Pinh. The chloroform extract exhibited substantial antileishmanial activity of Leishmania donovani. Verminoside(1) showed weak inhibition of the CB1, CB2, and Kappa opioid receptors. Compound 4 exhibited weak inhibition of the Kappa and Mu opioid receptors. The hexanes and the chloroform extracts of K. africana exhibited inhibitory activity against the pathogenic parasite Trypanosoma brucei. The ethyl acetate extract showed the same activity. Conclusions: This is the first report on the isolation of coniferyl 4-0-(3-D-glucopyranoside(7), a eucommiol derivative(crescentin IV)(6), and 6-feruloylcatalpol(4) from the genus Kigelia. It is also the first report on the separation of ajugol(2), catalpol(3), and specioside(5) from the fruits of K. africana. Revision of the^1 H and ^(13)C-NMR spectra of 6-feruloylcatalop(4) and 6-p-hydroxycinnamoylcatalpol(5, specioside) is described. Further, the results of the in vitro assays corroborate the traditional utility of this plant in medicine.

关键词： Anticryptoccocal antileishmanial cannabinoid receptors Kigelia africana opioid receptors

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Alteration of endocannabinoid system in human gliomas

Alteration of endocannabinoid system in human gliomas

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2011中华医学会神经外科学学术会议

作者：吴喜跃韩丽君李容任杰江常震黄睿谢宝英傅谨 Dept of Neurosurgery First Affiliated HospitalFujian Medical University Dept of Pharmacology Medical collegeXiamen University.

Endocannabinoids are lipid mediators that control central and peripheral neural functions. Recent studies have shown an anti-tumor effect of cannabinoids, mainly with D9-tetrahydrocannabinol (THC). However, the biolog... 详细信息

关键词： Endocannbinoids Glia tumors Human brain cannabinoid receptors

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