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Flavanols from the camellia sinensis *** and their hypoglycemic and hypolipidemic activities

Acta Pharmaceutica Sinica B 2017年第3期7卷 342-346页

作者： Xin Wang Quan Liu Hongbo Zhu Hongqing Wang Jie Kang Zhufang Shen Ruoyun Chen State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named(–)-epicatechin-3-O-(Z)-coumarate(1), and 16 known analogs(2–17) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α-glucosidases and lipases in vitro;compound 15 showed moderate inhibitory effect against sucrase with an IC_(50) value of 32.5 μmol/L and significant inhibitory effect against maltase with an IC_(50) value of 1.3 μmol/L. Compounds 8, 10, 11 and15 displayed moderate activity against a lipase with IC_(50) values of 16.0, 13.6, 19.8, and 13.3 μmol/L,respectively.

关键词： camellia sinensis var. assamica Pu-erh tea Flavanol Hypoglycemic Hypolipidemic

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ANTIOXIDANT PHENOLIC COMPOUNDS IN PU-ER TEA

ANTIOXIDANT PHENOLIC COMPOUNDS IN PU-ER TEA

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2005 International Symposium on Innovation in Tea Science and Sustainable Development in Tea Industry

作者： LIN Zhi, LV Haipeng, CUI Wenrui, SHE Gaimei, ZHANG Yingjun and YANG Chongren State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China Key Laboratory of Tea Chemical Engineering, Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Science, Hangzhou, 310008, China

＜正＞Eleven phenolic compounds were isolated from the EtOAc extract of Pu-Er tea, which was produced by a post fermented process using the crude green tea prepared from the leaves of camellia sinensis var. assamica in Mengku, Shuangjiang county, Yunnan Province. Their structures were identified as gallocatechin （1）, （-）-epicatechin （2）, （+）- catechin （3）, myricetin （4）, gallic acid （5）, kaempferol （6）, kaempferol-3-O- -D-glucopyranoside （7）, kaempferol-3-O-rutinoside （8）, quercetin （9）, quercetin-3- -D-glucopyranoside （10）, 2,5-dihydroxy- benzoic acid （11）. Compounds 6, 7, 8, 9, 10, 11 were firstly isolated from Pu-Er tea. All of isolated compounds were tested for their antioxidant activities by DPPH radical scavenging assay. It was found that compounds 2, 3 and 5 showed antioxidant activity closed with that of positive control, L-ascorbic acid, and the flavonoids （5, 6 and 9） are more active than the flavonoid glycosides （7, 8 and 10） and compound 11, indicating that gallic acid and simple catechins were main antioxidant phenolic compounds in Pu-er tea.

关键词： camellia sinensis var. assamica Pu-Er tea phenolic compounds antioxidant

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