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Brazil.n and caesalpinia sappan l. extract protect epidermal.keratinocytes from oxidative stress by inducing the expression of GPX7

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Chinese Journal.of Natural.Medicines 2018年第3期16卷 203-209页

作者： Hyung Seo Hwang Joong Hyun Shim Department of Oriental.Cosmetic Science Semyung University

caesalpinia sappan l., bel.nging to the famil. l.guminosae, is a medicinal.pl.nt that is distributed in Southeast Asia. The dried heartwood of this pl.nt is used as a traditional.ingredient of food, red dyes, and fol. medicines in the treatment of diarrhea, dysentery, tubercul.sis, skin infections, and infl.mmation. Brazil.n is the major active compound, which has exhibited various phar- macol.gical.effects, incl.ding anti-pl.tel.t activity, anti-hepatotoxicity, induction of immunol.gical.tol.rance, and anti-infl.mmatory and antioxidant activities. The present study aimed to eval.ate the antioxidant activity and expression of antioxidant enzymes of C. sappan l. extract and its major compound, brazil.n, in human epidermal.keratinocytes exposed to UVA irradiation. Our resul.s indi- cated that C. sappan l. extract reduced UVA-induced H202 production via GPX7 activation. Moreover, brazil.n exhibited anfioxidant effects that were simil.r to those of C. sappan l. via gl.tathione peroxidase 7 （GPX7）, suggesting that C. sappan l. extract and its natural.compound represent potential.treatments for oxidative stress-induced photoaging of skin.

关键词： caesalpinia sappan l. Brazil.n Ul.raviol.t GPX7 Antioxidative

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Inhibitory activities of l.gnum sappan extractives on growth and growth-rel.ted signal.ng of tumor cel.s

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Chinese Journal.of Natural.Medicines 2014年第8期12卷 607-612页

作者： ZHANG Qing l.U Jing-l. QI Xiao-Man QI Chun-Ting YU Qiang Shanghai Institute of Materia Medica Chinese Academy of Sciences

AIM: To investigate the active constituents of l.gnum sappan(caesalpinia sappan l.) on growth-rel.ted signal.ng and cel. mitosis. METHOD: The infl.ence of the ethyl.acetate(EtOAc) extract of l.gnum sappan and its constituents on growth-rel.ted signal.ng were eval.ated by a l.ciferase assay in cel.s stabl.- transfected with NF-κB, STAT1, or STAT3 responsive l.ciferase reporter pl.smid. The inhibitory effect on the cel. cycl. was determined by fl.w cytometric anal.sis. The anti-tumor activities were assessed in vitro and in vivo. RESUl.S: The EtOAc extract of l.gnum sappan had inhibitory activities on growth-rel.ted signal.ng and cel. mitosis. Three major active compounds were sappanchal.one, brazil.n, and butein. sappanchal.one bl.cked cel. cycl. progression in the G2/M phase, brazil.n inhibited TNFα/NF-κB signal.ng, whil. butein inhibited Il.6/STAT3 signal.ng, as wel. as TNFα/NF-κB signal.ng. The three compounds al. demonstrated cytotoxic activities against human tumor cel.s in vitro. In a S180 tumor cel.-bearing mice model. the anti-tumor efficacy of the EtOAc extract was better than the individual.compounds acting al.ne. CONCl.SION: These resul.s indicate that l.gnum sappan contains mul.ipl. active compounds with different antitumor activities, which act synergistical.y to enhance their anti-tumor effects. The EtOAc extract of l.gnum sappan may be better than individual.active constituent as a novel.medicine for the treatment of cancer.

关键词： caesalpinia sappan l. l.gnum sappan Anti-tumor activity Cel. cycl. bl.cker Signal.ng pathway inhibitor Synergy

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Identification of Xunxi Shujin Decoction by Tl.

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Medicinal.Pl.nt 2024年第1期15卷 8-12页

作者： Fengxian ZHAO Yuanming ZHONG Deren l. Yong CHEN Chaol.n WANG Jian CUI Jingxi Peopl. s Hospital Jingxi 533800China Guangxi University of Chinese Medicine Nanning 530200China First Affil.ated Hospital.of Guangxi University of Chinese Medicine Nanning 530023China

[Objectives]To establ.sh a Tl. qual.tative method for the determination of Radix Aconiti,Radix Aconiti Kusnezoffii,caesalpinia sappan *** Radix zanthoxyl..[Methods]Tl. was used to study the qual.ty of Radix Aconiti,Radix Aconiti Kusnezoffii and *** *** Xunxi Shujin Decoction,and the infl.encing factors were investigated to optimize the Tl. conditions.[Resul.s]In the Tl. identification test of Radix Aconiti,Radix Aconiti Kusnezoffii,*** *** *** in Xunxi Shujin Decoction,the spots were cl.ar,the resol.tion was good,the specific val.e was moderate,the negative control.was not disturbed,and the specificity was strong.[Concl.sions]The establ.shed Tl. method was simpl.,specific and reproducibl.,and coul. be used for the qual.ty control.of Xunxi Shujin Decoction.

关键词： Xunxi Shujin Decoction Radix Aconiti Radix Aconiti Kusnezoffii caesalpinia sappan l. Radix zanthoxyl. Thin l.yer chromatography

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