检索结果-南通市图书馆

Persistent cxcR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer

引用

World Journal of Gastroenterology 2006年第47期12卷 7585-7590页

作者： Kenji Koishi Reigetsu Yoshikawa Tohru Tsujimura Tomoko Hashimoto-Tamaoki Syoudou Kojima Hidenori Yanagi Takehira Yamamura Yoshinori Fujiwara Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Second Department of Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Genetics Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan

AIM: To study the effect of cxc chemokine receptor-4 (cxcR4) expression on disease progression and prognosis in esophageal cancer. METHODS: cxcR4 expression was evaluated in 37 patients with histologically confirmed esophageal squamous carcinomas (ESCC) undergoing preoperative chemoradiotherapy (CRT) by immunohistochemical staining. RESULTS: Eleven out of 37 ESCC patients showed a pathological complete response (CR) after CRT. cxcR4 protein expression was observed in cell cytoplasms of 13 tumors, and null expression was seen in 13 tumors. Distant recurrence was significantly more common in patients with positive cxcR4 expression (P = 0.0318). After a median follow-up time of 31.6 mo, 19 patients progressed (12 of 19 expressed positive cxcR4) and 11 died (10 of 11 expressed positive cxcR4). Overall survival was significantly correlated with lymph node metastasis (952.1 ± 53.8 d in negative group vs 475.1 ± 56.2 d in positive group, P = 0.023), distant metastasis (874.0 ± 60.4 d in negative group vs 434.9 ± 75.2 d in positive group, P = 0.014) and CRT (811.5 ± 51.2 d in responder group vs 459.6 ± 94.0 d in non-responder group, P = 0.00038) and further with an absence ofcxcR4 expression or no residual tumor (959.8 ± 51.0 d in null expression or no tumor group vs 412.0 ± 57.1 d in positive expression group, P = 0.0001). CONCLUSION: Persistent positive cxcR4 expression is implicated in tumor aggressiveness and poor prognosis in ESCC after CRT, and preoperative CRT may improve the prognosis of ESCC via cxcL12-cxcR4 signaling pathway.

关键词： cxc chemokine receptor-4 Metastasis Chemoradiotherapy Esophageal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cxcR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma

引用

World Journal of Gastroenterology 2011年第19期17卷 2389-2396页

作者： Bao-Cheng Zhao Zhen-Jun Wang Wei-Zheng Mao Hua-Chong Ma Jia-Gang Han Bo Zhao Hui-Min Xu Department of General Surgery Beijing Chaoy- ang Hospital Capital Medical University Beijing 100020 China Department of General Surgery Qingdao Mu- nicipal Hospital Qingdao University Medical College Qingdao 266071 Shandong Province China Department of General Surgery Weifang People's Hospital Weifang 261041 Shangdong Province China

AIM:To investigate the role of cxc chemokine receptor-4 (cxcR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric ***:In 40 cases of gastric cancer,expression of cxcR4 mRNA in cancer and normal mucous membrane and SDF-1 mRNA in lymph nodes around the stomach was detected using quantitative polymerase chain reaction (PCR) (TaqMan) and immunohistochemistric ***-7901 and MGC80-3 cancer cells were used to investigate the effect of SDF-1 on cell proliferation and ***:Quantitative reverse transcription PCR and immunohistochemistry revealed that the expression level of cxcR4 in gastric cancer was significantly higher than that in normal mucous membrane (1.6244 ± 1.3801 vs 1.0715 ± 0.5243,P cxcR4 mRNA in gastric cancer with lymph node metastasis was also significantly higher than that without lymph node metastasis (0.823 ± 0.551 vs 0.392 ± 0.338,P cxcR4 expression was significantly related to poorly differentiated,high tumor stage and lymph node *** differences in the expression level of SDF-1 mRNA were found between lymph nodes in metastatic gastric cancer and normal nodes (0.5432 ± 0.4907 vs 0.2640 ± 0.2601,P cxcR4 mRNA in gastric cancer (r=0.776,P cxcR4 and showed vigorous proliferation and migratory responses to ***3100 (a specific cxcR4 antagonist) was also found to effectively reduce the migration of gastric cancer ***:The cxcR4/SDF-1 axis is involved in the lymph node metastasis of gastric ***4 is considered as a potential therapeutic target in the treatment of gastric cancer.

关键词： Gastric carcinoma chemokines Stromal cell-derived factor-1 cxc chemokine receptor-4 Lymph node metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chemokine receptor cxcR4-prognostic factor for gastrointestinal tumors

引用

World Journal of Gastroenterology 2008年第30期14卷 4721-4724页

作者： Carl C Schimanski Peter R Galle Markus Moehler First Department of Internal Medicine of Johannes Gutenberg University of Mainz

To review the implication of cxcR4 for gastrointestinal cancer, a ＂Pubmed＂ analysis was performed in order to evaluate the relevance of cxcR4 and its ligands for gastrointestinal cancers. Search terms applied were ＂cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, cxcR4, SDF- 1α, and SDF-1β＂. cxcR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The cxcR4 ligand SDF-1α might act as ＂chemorepellent＂ while SDF-1β might act as ＂chemorepellent＂ for CTLs, inducing tumor rejection. The paracrine expression of SDF-1α was furthermore closely associated with neoangiogenesis. cxcR4 and its ligands influence the dissemination, immune rejection, and neoangiogenesis of human gastrointestinal cancers. Inhibition of cxcR4 might be an interesting therapeutic option.

关键词： cxc chemokine receptor-4 cxcL12,Stromal-derived-factor-1 Cancer Malignoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：