检索结果-南通市图书馆

BIOTRANSFORMATION　OF　2α，5α，10β，14β－TETRA－ACETOXY－4（20），11－TAXADIENE　BY　THE　FUNGIJS　cunninghamella　ECHINULATA

Chinese Chemical Letters 1996年第6期7卷 543-544页

作者： Shang Hut HU Xu Fang TIAN Wei Hua ZHU and Qi Cheng FANG(Institute of Materia Medica, Chinese Academy or Medical Sciencesand Peking Union Medical College, Beijing 1000050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050

?5α,10β,14β-Tetra-acctoxy-4(20).11-taxadicne (1) could be regioselectively transfonnedinto 6α 10β-dihydroxy-2α,5α,14β-triacetoxy-4(20). 11- taxadiene (2) by cunninghamella echinnlata infair yield. 6βM.10β-Dihydroxy-2α,5α,14β-triacet 11-taxadienc (3). 10β-hydroxy-2α,5α,14β-triacetoxy-4(20).11-taxadiene (4), 10 β-hyboxy-4β,20-epoxy -2α,5α,14β-triacetoxy- tax - 11- ene (5)asminor prpducts were also isolated

关键词： TETRA OF FUNGIJS THE cunninghamella ECHINULATA BY ACETOXY BIOTRANSFORMATION

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Successful treatment of invasive fungal rhinosinusitis caused by cunninghamella: A case report and review of the literature

引用

World Journal of Clinical Cases 2019年第2期7卷 228-235页

作者： Yong-Cai Liu Min-Li Zhou Ke-Jia Cheng Shui-Hong Zhou Xue Wen Cheng-Dong Chang Department of Otolaryngology the First Affiliated Hospital College of Medicine Zhejiang University Department of Pathology the First Affiliated Hospital College of Medicine Zhejiang University

BACKGROUND Invasive fungal rhinosinusitis(IFR) caused by cunninghamella is very rare but has an extremely high fatality rate. There have been only seven cases of IFR caused by cunninghamella reported in English and, of these, only three patients *** this article, we present another case of IFR caused by cunninghamella, in which the patient was initially treated successfully but then deteriorated due to a relapse of leukemia 2 mo *** SUMMARY A 50-year-old woman presented with a 2-mo history of right ocular proptosis,blurred vision, rhinorrhea and nasal obstruction. Nasal endoscopic examination showed that the middle turbinate had become necrotic and fragile. Endoscopic sinus surgery and enucleation of the right orbital contents were performed successively. Additionally, the patient was treated with amphotericin B both systematically and topically. Secretion cultivation of the right eye canthus showed infection with cunninghamella, while postoperative pathology also revealed fungal infection. The patient's condition gradually stabilized after surgery. However, the patient underwent chemotherapy again due to a relapse of leukemia 2 mo later. Unfortunately, her leukocyte count decreased dramatically,leading to a fatal lung infection and *** Aggressive surgical debridements, followed by antifungal drug treatment both systematically and topically, are the most important fundamental treatments for IFR.

关键词： cunninghamella Invasive fungal rhinosinusitis Acute myeloid leukemia Treatment Prognosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phase II metabolites of etofesalamide in filamentous fungi

引用

Acta Pharmacologica Sinica 2005年第7期26卷 893-896页

作者： Hai-hua HUANG Gui-lei MA Yu-ming SUN~2 Qiang LI~2 Da-fang ZHONG~(2,3) Department of Pharmaceutical Microbiology 2 Laboratory of Drug Metabolism and Pharmacokinetics,Shenyang Pharmaceutical University,Shenyang 110016,China Department of Pharmaceutical Microbiology Shenyang Pharmaceutical University Shenyang China Laboratory of Drug Metabolism and Pharmacokinetics Shenyang Pharmaceutical University Shenyang China

Aim:To study phase Ⅱ metabolites of etofesalamide in filamentous ***:Seven fungi were screened to transform *** metabolites ofetofesalamide were assayed using liquid chromatography coupled to *** major metabolite was subject to enzymatic hydrolysis to con-firm its ***:Etofesalamide was converted into two phase Ⅱmetabolites:glucoside and riboside *** conjugate was themajor product with a yield greater than 90%;no phase I metabolites were ***:Glucoside and riboside conjugations of etofesalamide in filamentousfungi differ from the phase Ⅱ metabolism of glucuronidation in mammals.

关键词： etofesalamide cunninghamella metabolite transformation: mass spectrum analysis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

微生物转化合成羟基化青藤碱及其条件优化

引用

北京中医药大学学报 2008年第10期31卷 702-704,707页

作者：陈磊刘怡卢建秋张宏桂北京中医药大学中药学院北京100102 河南中医学院药学院北京中医药大学中医药科技发展中心

目的首次对青藤碱进行微生物羟基化转化合成研究,并对转化条件进行优化得到最佳工艺。方法选取10株具有羟基化能力的菌株对青藤碱进行转化,采用TLC、HPLC-MSn方法检测原药及其转化物,优选出能使青藤碱羟基化的高活性菌株和最佳转化条件... 详细信息

目的首次对青藤碱进行微生物羟基化转化合成研究,并对转化条件进行优化得到最佳工艺。方法选取10株具有羟基化能力的菌株对青藤碱进行转化,采用TLC、HPLC-MSn方法检测原药及其转化物,优选出能使青藤碱羟基化的高活性菌株和最佳转化条件。结果10株菌株经过筛选,有三株菌可使青藤碱羟基化,经过复筛cunninghamella M2为最佳活性菌株:在摇床转速180r/min下,最适培养时间为6d,初始pH为6.5,培养温度为28℃,最大底物投料浓度不大于200mg/L时,可使青藤碱羟基化率大于95%。结论cunninghamella M2转化修饰青藤碱生成其羟基化物的专属性强、转化效率高。

关键词：青藤碱羟基化微生物转化 cunninghamella M2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：